<p>P53-positive expression in dysplastic surgical margins is a predictor of tumor recurrence in patients with early oral squamous cell carcinoma</p>

Abstract

Purpose This was a retrospective analysis of the impact of the expression of p53 in the dys-plastic surgical margins of early oral squamous cell carcinoma (OSCC) (pT1-2, N0). Patients and methods Seventy-two patients with early oral squamous cell carcinoma (OSCC) were recruited. Margin characteristics were abstracted from the pathology report. Expression of p53 in dysplastic surgical margins was examined with the immunohistochemical method and was correlated with clinicopathological parameters and clinical outcomes. Results Patients with moderate/severe dysplasia had poor local relapse-free survival (RFS) compared to those with mild dysplasia. Thirty-two (44.4%) had at least one p53-positive margin, and there was a significant association between the expression of p53 and tumor recurrence ( P <0.001). p53-positive expression was correlated with RFS in patients with dysplastic margins, and its expression in moderate/severe dysplastic groups had a worse RFS than mild dysplastic groups. We also found that the grade of the dysplasia margin was not correlated with RFS in p53-negative groups. Multivariable analysis validated p53 expression in dysplastic surgical margins as an independent risk factor for recurrence. Conclusion Our results validated that p53 expression was an independent risk factor for early OSCC with dysplastic surgical margins. Additional therapy and close follow-up are needed for these patients.

Concomitant overexpression of Activin A and p63 is associated with poor outcome in oral cancer patients

“…Contradictorily, our results indicate that expression of Activin βA is more prominent in adjacent normal tissues than tumors, suggesting that this molecular alteration could be an early event during progression from normal oral mucosa to oral cancer where chronic exposure of oral mucosa to tobacco carcinogens is common. Such early molecular changes have been previously reported by others 20,21 and by our group where we reported an upregulation of survivin 2B and survivin 3α isoforms in adjacent normal versus oral cancer tissues. 10 Our study revealed an association of Activin βA with prognosis in oral cancer, as high Activin βA expression was associated with advanced tumor stage, regional lymph node metastases, and poor recurrence-free and overall survival, supporting its oncogenic role in oral cancer.…”

Expression of p53 at invasive front of oral squamous cell carcinoma and negative histopathological surgical margins to establish correlation at 3-year survival

“…However, relapse often occurs with clear SMs, so it becomes imperative to assess the status of SM by molecular marker. [ 8 ]…”

“…The molecular marker p53 has been established to predict for recurrence and survival of OSCC patients. [ 8 ] Keeping this in mind, in this study, p53 protein expression was evaluated in the invasive front of OSCC as well as in histologically negative SMs of resected OSCC and its correlation with 3-year survival of OSCC.…”

Toward a Molecular Classification of the Head and Neck Squamous Cell Carcinoma

“…P53 as an independent risk factor has been demonstrated in early OSCC with dysplastic surgical margin. It may be a useful marker for postoperative decision for these patients [43,44].…”