<p>Normal lung attenuation distribution and lung volume on computed tomography in a Chinese population</p>

Abstract

Backgroud and objectives: Although lung attenuation distribution and lung volume on computed tomography (CT) have been widely used in evaluating COPD and interstitial lung disease, there are only a few studies regarding the normal range of these indices, especially in Chinese subjects. We aimed to describe the normal range of lung attenuation distribution and lung volume based on CT. Methods: Subjects with normal lung function and basically normal chest CT findings (derivation group) at Ruijin Hospital, Shanghai (from January 2010 to June 2014) were included according to inclusion and exclusion criteria. The range of the percentage of lung volume occupied by low attenuation areas (LAA%), percentile of the histogram of attenuation values (Perc n), and total lung volume were analyzed. Relationships of these measures with demographic variables were evaluated. Participants who underwent chest CT examination for disease screening and had basically normal CT findings served as an external validation group. Results: The number of subjects in the derivation group and external validation groups were 564 and 1,787, respectively. Mean total lung volumes were 4,468±1,271 mL and 4,668±1,192 mL, and median LAA%(-950 HU) was 0.19 (0.03–0.43) and 0.17 (0.01–0.41), in the derivation and external validation groups, respectively. Reference equations for lung volume and attenuation distribution (LAA% using -1,000–210 HU, Perc 1 to Perc 98) were generated: Lung volume (mL) = -1.015 *10^4+605.3*Sex (1= male, 0= female)+92.61*Height (cm) –12.99*Weight (kg) ±1766; LAA% (-950 HU)=[0.2027+0.05926*Sex (1= male, 0= female) –4.111*10^-3*Weight (kg) +4.924*10^-3*Height (cm) +8.504*10^-4*Age]^7.341–0.05; Upper limit of normal range: [0.2027+0.05926*Sex-4.111*10^-3*Weight+4.924*10^-3*Height+8.504*10^-4*Age+0.1993]^7.341–0.05. Conclusion: This large population-based retrospective study demonstrated the normal range of LAA%, Perc n, and total lung volume measured on CT scans among subjects with normal lung function and CT findings. Reference equations are provided.

Is lung density associated with severity of COVID-19?

“…Cheng et al . analysed 2351 lung-healthy patients for lung density on CT and found a low-density percentage of 17–19% [ 23 ], comparable to the values reported in Table 1 . It is therefore possible that in a patient population with lung disease and a significantly higher proportion of emphysema, CT-based quantification and analysis of low-density lung-volume could still be useful to model the severity of COVID-19.…”

A Preliminary Study on the Relationship Between High-resolution Computed Tomography and Lung Function in People at Risk of Developing Chronic Obstructive Pulmonary Disease

“…In our study, we also found that the left, right, and bilateral lung mean expiratory lung density showed signi cantly positive correlation with FEV1/FVC. This is in accordance with the conclusion arrived at by previously published studies [30][31][32].…”

A Correlation Between Quantitative Measurement Parameters of Thorax Computed Tomography and Pulmonary Function Test: A Retrospective Study

“…In our study, there were similar correlation findings of PFT parameters with lung CT density-volumetry, compatible with the literature 5,7,11,19 . TLV and TLD in the current study were found to be 3820±1272.35 and -1597.17±295.70, respectively.…”

“…In this paper, we aimed to evaluate PFT and CT volumetric results in normal population and whether CT volumetric values could be a good predictor for the assessment of PFT specially in extraordinary situations such as coronavirus disease-2019 (COVID- 19), in which PFT is impossible to be performed.…”