&lt;p&gt;Non-Small Cell Lung Cancer in Young Patients: An Analysis of Clinical, Pathologic and TNM Stage Characteristics Compared to the Elderly&lt;/p&gt;

Jin, Xin; Zhao, Xin; Liu, Xingsheng; Han, Ke; Lu, Gaojun; Zhang, Yi

doi:10.2147/rmhp.s264274

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…Young patients are more likely to ignore clinical manifestations because the early symptoms are not obvious. Meanwhile, studies have shown that younger patients in various cancers have more distant metastasis (DM) and poorer outcomes than older patients (7,8). Nevertheless, many GC patients are typically diagnosed at an advanced or metastatic stage, indicating a dismal 5-year survival rate of less than 30% (9).…”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period

Deng

Duan

et al. 2023

Front. Oncol.

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BackgroundAlthough the overall global incidence of gastric cancer has been declining, the number of new cases in people under the age of 50 is increasing, which is related to metastasis, late pathological stages, and poor prognosis. There is a scarcity of large-scale studies to evaluate and predict distant metastasis in patients with early-onset gastric cancer.MethodsFrom January 2010 to December 2019, data on early-onset GC patients undergoing surgery were gathered from the Surveillance, Epidemiology, and End Results (SEER) database. We investigated the independent risk factors for distant metastasis in patients with early-onset gastric cancer. Based on these risk factors, we developed a nomogram to predict distant metastasis. The model underwent internal validation on the test set and external validation on 205 patients from the First Affiliated Hospital of Sun Yat-sen University and the seventh Affiliated Hospital of Sun Yat-sen University. The novel nomogram model was then evaluated using the receiver operating characteristic (ROC) curve, calibration, the area under the curve (AUC), and decision curve analysis (DCA). The training set nomogram score was used to classify the different risk clusters of distant metastasis.ResultsOur study enrolled 2217 patients after establishing the inclusion and exclusion criteria, with 1873 having no distant metastasis and 344 having distant metastasis. The tumor size, total lymph nodes, whether or not receiving radiotherapy and chemotherapy, T stage, and N stage were significant predictors of advanced distant metastasis (p < 0.05). The AUC of the ROC analysis demonstrated our model’s high accuracy. Simultaneously, the prediction model shows high stability and clinical practicability in the calibration curve and DCA analysis.ConclusionsWe developed an innovative nomogram containing clinical and pathological characteristics to predict distant metastasis in patients younger than 50 years old with gastric cancer. The tool can alert clinicians about distant metastasis and help them develop more effective clinical treatment plans.

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Section: Introductionmentioning

confidence: 99%

Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period

Deng

Duan

et al. 2023

Front. Oncol.

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“…Lung cancer is primarily a disease of the older population, with about 10% of patients <55 years at diagnosis (10). Several studies have revealed that younger patients with non-small cell lung cancer (NSCLC) represent a distinct clinico-biologic entity (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Compared to older adults, young NSCLC patients are more likely to be women, Asians, or Pacific Islanders, have adenocarcinoma histology, and present with metastases (11)(12)(13)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have revealed that younger patients with non-small cell lung cancer (NSCLC) represent a distinct clinico-biologic entity (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Compared to older adults, young NSCLC patients are more likely to be women, Asians, or Pacific Islanders, have adenocarcinoma histology, and present with metastases (11)(12)(13)(16)(17)(18)(19). NSCLC patients <50 are significantly more likely to harbor driver mutations suitable for treatment with a growing array of targeted therapies (13,20).…”

Section: Introductionmentioning

confidence: 99%

Small cell lung cancer in young patients: trends in sociodemographic factors, diagnosis, treatment, and survival

Lee¹,

Qureshi²,

Suzuki³

et al. 2022

J Thorac Dis

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Background: Small cell lung cancer (SCLC) in patients <50 years old has unique socioeconomic and clinical implications. We aimed to examine the demographics, treatment patterns, and survival of young patients with SCLC and compared them to older adults. Methods:The National Cancer Database (NCDB) was queried to identify SCLC cases diagnosed from 2004 to 2016. Patients were divided into three age groups: 18-50, 50-70, and ≥70 years. Patient characteristics were evaluated for survival within each age group. Kaplan-Meier and Cox regression analyses were used to assess survival.Results: Of the 172,453 evaluated SCLC patients (median age 66 years), 8,792 were 18-50 years old.Compared to the older groups, patients under 50 were more likely to be Black, uninsured or on Medicaid, have household income <$30,000, and present with stage III or IV disease (P<0.0001 for all). While young patients were more likely to receive guideline-concordant care (GCC), the hazard of death increased to 1.96 (95% CI: 1.80-2.14; P<0.0001) with receipt of nonstandard therapy. Private insurance, female gender, non-White race, Hispanic ethnicity, and higher income were associated with better survival. The youngest cohort had significantly better survival overall when compared to the older patients (P<0.0001), but the survival advantage was reduced with the advancing stage.Conclusions: SCLC patients under 50 years old represent a socioeconomically disadvantaged group with advanced disease at presentation. Despite having fewer comorbidities and being offered guideline-concordant treatment, younger patients with SCLC have only marginally better survival than older patients in advanced stages.

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“…Non-small cell lung cancer accounts for 85% of all cases, and adenocarcinoma is the most common pathological subtype [2]. Currently, TNM staging according to the American Joint Committee on Cancer (AJCC) guideline is used for the stratification of lung adenocarcinoma to predict clinical outcomes and to decide upon treatment strategies; however, the treatment responses and prognoses of patients rated at the same TNM stage vary widely [3][4][5]. Therefore, research leading to the development of more accurate methods beyond TNM staging for patient stratification in lung adenocarcinoma is actively underway [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of an integrative analysis of [18F]FDG PET parameters and infiltrating immune cell scores in lung adenocarcinoma

Choi

Sarker²,

Choi³

et al. 2022

EJNMMI Res

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Background High levels of 18F-fluorodeoxyglucose (18F-FDG) tumor uptake are associated with worse prognosis in patients with non-small cell lung cancer (NSCLC). Meanwhile, high levels of immune cell infiltration in primary tumor have been linked to better prognosis in NSCLC. We conducted this study for precisely stratified prognosis of the lung adenocarcinoma patients using the integration of 18F-FDG positron emission tomography (PET) parameters and infiltrating immune cell scores as assessed by a genomic analysis. Results Using an RNA sequencing dataset, the patients were divided into three subtype groups. Additionally, 24 different immune cell scores and cytolytic scores (CYT) were obtained. In 18F-FDG PET scans, PET parameters of the primary tumors were obtained. An ANOVA test, a Chi-square test and a correlation analysis were also conducted. A Kaplan–Meier survival analysis with the log-rank test and multivariable Cox regression test was performed to evaluate prognostic values of the parameters. The terminal respiratory unit (TRU) group demonstrated lower 18F-FDG PET parameters, more females, and lower stages than the other groups. Meanwhile, the proximal inflammatory (PI) group showed a significantly higher CYT score compared to the other groups (P = .001). Also, CYT showed a positive correlation with tumor-to-liver maximum standardized uptake value ratio (TLR) in the PI group (P = .027). A high TLR (P = .01) score of 18F-FDG PET parameters and a high T follicular helper cell (TFH) score (P = .005) of immune cell scores were associated with prognosis with opposite tendencies. Furthermore, TLR and TFH were predictive of overall survival even after adjusting for clinicopathologic features and others (P = .024 and .047). Conclusions A high TLR score was found to be associated with worse prognosis, while high CD8 T cell and TFH scores predicted better prognosis in lung adenocarcinoma. Furthermore, TLR and TFH can be used to predict prognosis independently in patients with lung adenocarcinoma.

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<p>Non-Small Cell Lung Cancer in Young Patients: An Analysis of Clinical, Pathologic and TNM Stage Characteristics Compared to the Elderly</p>

Cited by 7 publications

References 31 publications

Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period

Retrospective analysis of risk factors for distant metastasis of early-onset gastric cancer during the perioperative period

Small cell lung cancer in young patients: trends in sociodemographic factors, diagnosis, treatment, and survival

Prognostic impact of an integrative analysis of [18F]FDG PET parameters and infiltrating immune cell scores in lung adenocarcinoma

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