&lt;p&gt;Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma&lt;/p&gt;

Pan, Xin-Bin; Huang, Shan; Zhu, Xiaodong

doi:10.2147/cmar.s213264

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…An increased NLR or MLR before treatment is a poor prognostic factor for different cancers, including gastrointestinal cancers, soft tissue sarcomas, nasopharyngeal carcinoma, and lung cancer. [16][17][18][19] In our study, patients with low NLR and MLR values (NLR <2.85 and MLR <.30) had longer PFS and OS. The relative proportion of neutrophils is larger in patients with a high NLR and they tend to have worse prognosis.…”

Section: Discussionsupporting

confidence: 47%

Systemic Inflammatory Biomarkers Predict Survival of Patients Treated With Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma

Wang,

Qin,

Chai

et al. 2023

Cancer Control

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Objective We aimed to retrospectively investigate whether the neutrophil to lymphocyte ratio (NLR) and the monocyte to lymphocyte ratio (MLR) can predict the prognosis of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib or sorafenib. Methods We retrospectively identified 210 patients with mRCC treated with sunitinib or sorafenib from 2007 to 2017 at Fudan University- and Hexi University-affiliated hospitals. Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan–Meier method. Multivariate regression analysis was used to evaluate predictors of PFS and OS. Results Low NLR (<2.85) and MLR (<.30) were strongly associated with increased PFS and OS. Multivariable analyses verified that the NLR and MLR were both independent prognostic factors. Additionally, the NLR was negatively correlated with CD8+ and CD4+ T-cell infiltration in tumors. Conclusion In patients with mRCC treated with sunitinib and sorafenib, an NLR <2.85 and MLR <.30 was associated with superior PFS and OS, which may be related to the reduced lymphocytic infiltration of tumors.

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Section: Discussionsupporting

confidence: 47%

Systemic Inflammatory Biomarkers Predict Survival of Patients Treated With Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma

Wang,

Qin,

Chai

et al. 2023

Cancer Control

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“…The prognostic value of NLR, PLR, and SII has been reported in many types of cancers, including NPC. Pan et al ( 27 ) conducted a retrospective study in stage II NPC patients and found that NLR was an independent prognostic biomarker in stage II NPC patients; NLR≥2.92 was associated with poorer 5-year OS (84.3% vs. 97.4%, p =0.001). Another study in NPC patients without distant metastasis reported that NLR≥ 2.28 and PLR≥174 were significantly associated with a shorter OS ( p <0.05), and NLR≥2.28 was associated with a shorter PFS ( p <0.05) ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation Response Index Is a Predictor of Poor Survival in Locally Advanced Nasopharyngeal Carcinoma: A Propensity Score Matching Study

et al. 2020

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IntroductionNasopharyngeal carcinoma (NPC) is a common malignancy in China and known prognostic factors are limited. In this study, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) were evaluated as prognostic factors in locally advanced NPC patients.Materials and MethodsNPC patients who received curative radiation or chemoradiation between January 2012 and December 2015 at the Second Xiangya Hospital were retrospectively reviewed, and a total of 516 patients were shortlisted. After propensity score matching (PSM), 417 patients were eventually enrolled. Laboratory and clinical data were collected from the patients’ records. Receiver operating characteristic curve analysis was used to determine the optimal cut-off value. Survival curves were analyzed using the Kaplan-Meier method. The Cox proportional hazard model was used to identify prognostic variables.ResultsAfter PSM, all basic characteristics between patients in the high SIRI group and low SIRI group were balanced except for sex (p=0.001) and clinical stage (p=0.036). Univariate analysis showed that NLR (p=0.001), PLR (p=0.008), SII (p=0.001), and SIRI (p<0.001) were prognostic factors for progression-free survival (PFS) and overall survival (OS). However, further multivariate Cox regression analysis showed that only SIRI was an independent predictor of PFS and OS (hazard ratio (HR):2.83; 95% confidence interval (CI): 1.561-5.131; p=0.001, HR: 5.19; 95% CI: 2.588-10.406; p<0.001), respectively.ConclusionOur findings indicate that SIRI might be a promising predictive indicator of locally advanced NPC patients.

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“…3 Following the initial report of peripheral immune alteration in patients with malignant tumors in the 1960s, 4 the predictive effects of immune-related serum biomarkers on the progression, therapy, and prognosis of cancer have garnered attention. 5,6 While some studies have investigated the relationship between peripheral immune-related biomarkers and outcome in patients with NPC, 7,8 they have focused mainly toward a unidirectional NPC progression effect using Kaplan-Meier survival curves. To date, however, no research has clearly simulated a precise and integrated restricted spline curve that represents the relationship between immune-related indices and NPC.…”

Section: Introductionmentioning

confidence: 99%

Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma

et al. 2022

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Background We attempted to identify the most reliable immune‐related index for predicting nasopharyngeal carcinoma (NPC) prognosis and to reveal its precise and integrated relationship with NPC progression. Method One thousand seven hundred and six patients with newly diagnosed NPC (1320 from the primary cohort and 386 from the validated cohort) from January 2010 to March 2014 were enrolled. Clinical features and 12 immune‐related variables were analyzed. Results A high absolute lymphocyte count (ALC; >3.2 × 109/L) correlated with a poor prognosis of patients with NPC. Significant OS differences were discovered between patients with high ALC and no ALC elevation (p < 0.05, in primary cohort), showing similar prognostic risk to patients with advanced NPC (p > 0.05, in validated cohort). ALC improved the predictive performance of the basic tumor‐node‐metastasis prognostic model (p = 0.025), which was reliably validated in the external independent cohort. Conclusion High ALC is a surrogate marker for improved prognostic risk stratification in NPC.

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<p>Neutrophil-to-lymphocyte ratio predicts the prognosis of stage II nasopharyngeal carcinoma</p>

Cited by 10 publications

References 34 publications

Systemic Inflammatory Biomarkers Predict Survival of Patients Treated With Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma

Systemic Inflammatory Biomarkers Predict Survival of Patients Treated With Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma

Systemic Inflammation Response Index Is a Predictor of Poor Survival in Locally Advanced Nasopharyngeal Carcinoma: A Propensity Score Matching Study

Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma

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