<p>Neudesin in obesity and type 2 diabetes mellitus: the effect of acute fasting and weight reducing interventions</p>

Abstract

Context Neudesin has recently been identified as a novel regulator of energy expenditure in experimental animals; however, its role in humans remains unexplored. Objective The aim of this study was to assess the effects of obesity and type 2 diabetes mellitus (T2DM) along with selected weight reducing interventions on serum neudesin levels and adipose tissue mRNA expression. Patients and methods Fifteen obese subjects with T2DM undergoing endoscopic duodenal-jejunal bypass liner (DJBL) implantation, 17 obese subjects (11 with T2DM, 6 without T2DM) scheduled for gastric plication (GP), 15 subjects with functional hypoglycemia subjected to 72-hour acute fasting (AF), and 12 healthy controls were included in the study. Results Baseline neudesin levels were comparable between all groups. DJBL increased neudesin at 6 and 10 months after the procedure (1.77±0.86 vs 2.28±1.27 vs 2.13±1.02 ng/mL, P =0.001 for baseline vs 6 vs 10 months) along with reduction in body weight and improvement of HbA 1c without any effect on neudesin mRNA expression in subcutaneous adipose tissue. Conversely, GP did not affect neudesin levels despite marked reduction in body weight and improvement of HbA 1c . In contrast, AF decreased neudesin levels during the entire period (1.74±0.54 vs 1.46±0.48 ng/mL, P =0.001 for baseline vs 72 hours) with no impact of subsequent re-alimentation on neudesin concentrations. Conclusion Neudesin levels are differentially regulated during AF and chronic weight reduction induced by DJBL or GP. Further studies are needed to assess its possible significance in energy homeostasis regulation in humans.

Plasma Levels of Neudesin and Glucose Metabolism in Obese and Overweight Children

“…However, the serum concentrations of neudesin detected by Karatas et al. (2021) are about thirty times higher than those reported in our paper and in most of the previously published papers ( 17 , 19 , 21 – 23 ). Celikkol et al.…”

“…Kratochvilova et al. (2019) found no differences in serum neudesin levels among obese adults (81% with T2MD) undergoing endoscopic bariatric procedures, patients with functional hypoglycemia and healthy controls ( 17 ). On the other hand, recently Karatas et al.…”

Serum Neudesin Levels in Obese Adolescents

“…Kratochvilova et al ( 20 ) also investigated serum neudesin levels and its mRNA expression in subcutaneous and visceral adipose tissue in obese subjects with or without type 2 diabetes. They found that serum neudesin concentrations in obese subjects, both with and without type 2 diabetes, did not differ from healthy lean control subjects.…”

“…Kratochvilova et al ( 20 ) also reported a possible role of neudesin in the development of obesity-related metabolic disturbances, based on the observed effects of acute fasting and selected weight-reducing interventions, like endoscopic duodenojejunal bypass liner implantation or gastric plication. An obese diabetic group undergoing duodenojejunal bypass liner implantation showed significantly increased concentrations of circulating neudesin.…”

Review of Novel Potential Insulin Resistance Biomarkers in PCOS Patients—The Debate Is Still Open

“…Although neudesin was identified less than 20 years ago [ 164 ], it still remains mostly unexplored, and is only now becoming a subject of metabolism-related studies (in diseases, relating to obesity, diabetes mellitus, insulin resistance and PCOS) [ 34 , 167 , 168 , 169 , 170 , 171 , 172 ].…”