&lt;p&gt;Multiresistant &lt;em&gt;Fusarium&lt;/em&gt; Pathogens on Plants and Humans: Solutions in (from) the Antifungal Pipeline?&lt;/p&gt;

Al‐Hatmi, Abdullah M. S.; Hoog, G. Sybren de; Meis, Jacques F.

doi:10.2147/idr.s180912

Cited by 35 publications

(30 citation statements)

References 96 publications

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“…In addition, they recombined species originally described in Fusarium in this teleomorphic genus, thus promoting a de facto dual nomenclature that obscures the fact that Neocosmospora is nested phylogenetically within a monophyletic Fusarium ( 5 , 24 ; Geiser et al, submitted). There are potentially serious consequences associated with this because clinicians need to be aware that these fungi are broadly resistant to the spectrum of antifungals that are currently available ( 25 ). An identification as Neocosmospora would thus fail to connect a case to this crucial knowledge, thereby disregarding the valuable clinical information that distinguishes it from an identification as Fusarium .…”

Section: Perspectivementioning

confidence: 99%

No to Neocosmospora : Phylogenomic and Practical Reasons for Continued Inclusion of the Fusarium solani Species Complex in the Genus Fusarium

O’Donnell

Al‐Hatmi

Aoki

et al. 2020

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This article is to alert medical mycologists and infectious disease specialists of recent name changes of medically important species of the filamentous mold Fusarium. Fusarium species can cause localized and life-threating infections in humans. Of the 70 Fusarium species that have been reported to cause infections, close to one-third are members of the Fusarium solani species complex (FSSC), and they collectively account for approximately two-thirds of all reported Fusarium infections. Many of these species were recently given scientific names for the first time by a research group in the Netherlands, but they were misplaced in the genus Neocosmospora. In this paper, we present genetic arguments that strongly support inclusion of the FSSC in Fusarium. There are potentially serious consequences associated with using the name Neocosmospora for Fusarium species because clinicians need to be aware that fusaria are broadly resistant to the spectrum of antifungals that are currently available.

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Section: Perspectivementioning

confidence: 99%

No to Neocosmospora : Phylogenomic and Practical Reasons for Continued Inclusion of the Fusarium solani Species Complex in the Genus Fusarium

O’Donnell

Al‐Hatmi

Aoki

et al. 2020

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“…The taxonomy of the genus Fusarium , initially described by Link in 1809 as presenting banana shape conidia, has been changing in taxonomy over the years and it has become a controversial issue [ 8 ]. Currently, the genus Fusarium has been classified into species complexes, i.e., F. solani species complex (FSSC), F. oxysporum species complex (FOSC), Gibberella (Fusarium) fujikuroi species complex (GFSC), F. incarnatum – F. equiseti species complex (FIESC), F. sambucinum species complex (FSAMSC), F. tricinctum species complex (FTSC), F. chlamydosporum species complex (FCSC), and F. dimerum species complex (FDSC) [ 9 , 10 , 11 ]. In addition, the members of FSDC have been included in the genus Bisifusarium [ 12 ], and recently, it has been proposed that members of the F. solani species complex be moved to the genus Neocosmospora based on the results of phylogenetic analysis [ 13 ].…”

Section: The Fusarium Genusmentioning

confidence: 99%

“…Secondary resistance develops in response to exposure to an antimicrobial agent [ 96 ]. Both of these mechanisms have been reported in these fungi, although the molecular mechanisms of intrinsic resistance have not been described yet [ 11 ]. Secondary resistance to azoles has been demonstrated in A. fumigatus and is usually dependent on an altered expression of CYP51 , the gene encoding sterol 14α-demethylase [ 97 , 98 ].…”

Section: Antifungal Resistance Mechanismsmentioning

confidence: 99%

A One Health Perspective to Recognize Fusarium as Important in Clinical Practice

Sáenz

Álvarez-Moreno

Pape

et al. 2020

JoF

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Any strategy that proposes solutions to health-related problems recognizes that people, animals, and the environment are interconnected. Fusarium is an example of this interaction because it is capable of infecting plants, animals, and humans. This review provides information on various aspects of these relations and proposes how to approach fusariosis with a One Health methodology (a multidisciplinary, and multisectoral approach that can address urgent, ongoing, or potential health threats to humans, animals, and the environment). Here, we give a framework to understand infection pathogenesis, through the epidemiological triad, and explain how the broad utilization of fungicides in agriculture may play a role in the treatment of human fusariosis. We assess how plumbing systems and hospital environments might play a role as a reservoir for animal and human infections. We explain the role of antifungal resistance mechanisms in both humans and agriculture. Our review emphasizes the importance of developing interdisciplinary research studies where aquatic animals, plants, and human disease interactions can be explored through coordination and collaborative actions.

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“…paradoxa causes the black rot postharvest disease in pineapple [ 124 ] and also infects sugarcane [ 125 , 126 ], palm trees, cacao plants, and several other crops [ 127 ]. F. verticillioides is a producer of fumonisin, a carcinogenic mycotoxin [ 128 ], and other species have been described as emergent and opportunistic pathogens in humans [ 129 ]. Fávaro et al [ 125 ] monitored E. nigrum endophytically inoculated in sugarcane plants, and its extract significantly reduced the diameter of Fusarium verticillioides , Colletotrichum falcatum , Ceratocystis paradoxa , and Xanthomonas albilineans colonies at concentrations ranging from 0.1 to 2.0 mg/mL.…”

Section: Discussionmentioning

confidence: 99%

Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects

Cruz

Paula

Nogueira

et al. 2021

International Journal of Microbiology

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In this study, we report the isolation and identification of an endophytic strain of Burkholderia cepacia (COPS strain) associated with Polygala paniculata roots. Polygala plants are rich sources of promising microbiomes, of which the literature reports several pharmacological effects, such as trypanocidal, antinociceptive, anesthetic, anxiolytics, and anticonvulsant activities. B. cepacia COPS belongs to a new sequence type (ST 1870) and harbors a genome estimated in 8.3 Mbp which exhibits the aminoglycosides and beta-lactams resistance genes aph(3′)-IIa and blaTEM-116, respectively. Analysis performed using MLST, average nucleotide identity, and digital DNA-DNA hybridization support its species-level identification and reveals its novel housekeeping genes alleles gyrB, lepA, and phaC. The root endophyte B. cepacia COPS drew our attention from a group of 14 bacterial isolates during the primary screening for being potentially active against Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Micrococcus luteus ATCC 9341, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231 and exhibited the broad-spectrum activity against phytopathogenic fungi. In addition, COPS strain showed production of protease, lipase, and esterase in solid media, and its natural product extract showed potent inhibition against fungal plant pathogens, such as Moniliophthora perniciosa, whose antagonism index (89.32%) exceeded the positive control (74.17%), whereas Sclerotinia sclerotiorum and Ceratocystis paradoxa showed high percentages of inhibition (85.53% and 82.69%, respectively). COPS crude extract also significantly inhibited S. epidermidis ATCC 35984, E. faecium ATCC 700221 (MIC values of 32 μg/mL for both), E. faecalis ATCC 29212 (64 μg/mL), and S. aureus ATCC 25923 (128 μg/mL). We observed moderate antagonistic activity against A. baumannii ATCC 19606 and E. coli ATCC 25922 (both at 512 μg/mL), as well as potent cytotoxic effects on Leishmania infantum and Leishmania major promastigote forms with 78.25% and 57.30% inhibition. In conclusion, this study presents for the first time the isolation of an endophytic B. cepacia strain associated with P. paniculata and enough evidence that these plants may be considered a rich source of microbes for the fight against neglected diseases.

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<p>Multiresistant <em>Fusarium</em> Pathogens on Plants and Humans: Solutions in (from) the Antifungal Pipeline?</p>

Cited by 35 publications

References 96 publications

No to Neocosmospora : Phylogenomic and Practical Reasons for Continued Inclusion of the Fusarium solani Species Complex in the Genus Fusarium

No to Neocosmospora : Phylogenomic and Practical Reasons for Continued Inclusion of the Fusarium solani Species Complex in the Genus Fusarium

A One Health Perspective to Recognize Fusarium as Important in Clinical Practice

Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects

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