<p>Multifunctional Quaternary Phosphorus/Bromoargentate Hybrids: The Achievement of Greenish Blue Luminescence, Repeatable Photocurrent Responses and Durable Antimicrobial Activities with Enhanced Water Stability</p>

Abstract

Background: The realization of multifunction in one bulk material is fascinating for developing a new generation of devices. Quaternary phosphorus salts were seldom utilized as templates in haloargentate systems, and the hybridization of alkyl(triphenyl)phosphonium with halometallate will be a good strategy for the development of multifunctional material, especially for biological material. Methods: Under the template of (triphenyl)phosphonium-based quaternary phosphorus salts with different spacer lengths (n=2, 3, 4), three bromoargentate hybrids were constructed via the solution method, ie, (1,2-DBTPP)(Ag 2 Br 4) (1), {(1,3-DBTPP) 2 (Ag 7 Br 11)]•CH 3 CN•H 2 O} n (2), and {[(1,4-DBTPP)(Ag 5 Br 7)](CH 3 CN) 2 •H 2 O} n (3) (1,2-DBTPP 2+ =ethane-1,2-diylbis (triphenyl)phosphonium, 1,3-DBTPP 2+ =propane-1,3-diylbis (triphenyl)phosphonium, 1,4-DBTPP 2 + =butane-1,4-diylbis (triphenyl)phosphonium)). Results: The (Ag 7 Br 11) n 4nchain in 2 is a new type of 1-D bromoargentate chain constructed from cubane-like Ag 4 Br 4 nodes, AgBr 4 tetrahedrons and AgBr 3 triangles. Interestingly, by elongating spacer n from 2 to 4, argentophilicity interactions are weakened, and the hydrogen bonds are strengthened. Consequently, their water stabilities and photocurrents are improved, in which the Ag-4d/Br-4p to π* anti-bonding orbital of the quaternary phosphorus transfer is facilitated. Furthermore, the greenish blue emissions can be detected. Finally, high inhabitation rates against Streptococcus mutans and Candida albicans can be observed in 2 and 3. Conclusion: In all experiments, by elongating the spacer lengths of quaternary phosphorus salts, multifunctions were integrated in the quaternary phosphorus/bromoargentate hybrids, including greenish blue luminescence, repeatable photocurrent responses and durable antimicrobial activities with enhanced water stability. This work could provide a theoretical guide for the design of new biologically multifunctional materials.

Synthetic Antibacterial Quaternary Phosphorus Salts Promote Methicillin-Resistant Staphylococcus aureus-Infected Wound Healing

“…The assay was performed according to our previously validated method with minor changes. 27 Firstly, 180 µL of a MRSA cell suspension (1.0 × 10 6 CFU mL −1 ) in LB broth medium was seeded in a 96-well plate, and different concentrations of (1,4-DBTPP)Br 2 (0−128 μg mL −1 ) were added to each well. The growth curves of the MRSA cells were evaluated using an Automated Microbiology Analysis System (Bioscreen C, Turku, Finland) at 37 °C with shaking at 200 rpm.…”

“…Our results can help extend the biological applications of quaternary phosphonium salts. 27 Briefly, haloalkanes (10 mmoL) and Ph3P (30 mmoL) were dissolved in DMF (10 mL) and were reacted at 130 °C for 4 h. The mixtures were then cooled to room temperature, and the solvent was removed by rotation volatilization to extract the raw products, which were washed with n-hexane and dried in an oven.…”