<p>Multifactorial Assessment of Risk of Falling in 753 Post-Menopausal Women: A Multicenter Cross-Sectional Study by the Italian Group for the Study of Metabolic Bone Diseases</p>

Abstract

To assess physical performance, number of falls, previous fragility fractures, and ongoing pharmacological therapy in a cohort of post-menopausal women, according to their risk of falling. Methods: In this multicenter cross-sectional study, we recruited in a 3-year period (May 2016 to April 2019), women aged >60 years referred to seven Osteoporosis and Bone Metabolism Outpatient Services of the Italian Group for the Study of Metabolic Bone Diseases. The study population was divided into three groups according to the risk of falling, assessed through the Elderly Fall Screening Test (EFST): low risk (EFST score=0-1); moderate risk (EFST=2-3); high risk (EFST=4-5). Outcome measures were: 4-meter gait speed (4MGS); unipedal stance time (UST); number of falls in the previous year; previous fragility fractures; ongoing pharmacological therapy. Results: We analyzed 753 women (mean aged 70.1±9.2 years): 378 (50.2%) at low risk of falling, 247 (32.8%) at moderate risk, and 128 (17.0%) at high risk. 4MGS and UST resulted as pathological in the 93.9% and 99.2%, respectively, of women at high risk. There were significant differences among groups for both outcomes (p<0.001). There was also a significant difference among groups (p<0.001) in terms of previous falls and fragility fractures. Lastly, there were significant differences (p<0.05) among groups in using antihypertensive drugs, antiplatelet agents, anticoagulants, antidepressants, anti-osteoporotic drugs, and vitamin D, and/or calcium supplementation. Conclusion: Physical performance, prevalence of falls and fragility fractures, and an assessment of pharmacological therapy should be investigated in post-menopausal women because of their significant correlation with risk of falling.

Risk Factors for New Vertebral Fracture After Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures

“…Osteoporosis medication can effectively prevent or even reverse bone loss. 31 Hoff et al 32 screened 28,461 volunteers and analyzed the effects of osteoporosis medication on fracture incidence, which was significantly lower in the treated than in the untreated group, thus, highlighting the importance of medical interventions for bone loss. In our study, postoperative osteoporosis treatment (OR=0.413, 95% CI=0.305–0.560, P<0.0001) was a protective factor for new vertebral fractures.…”

Optimization of transdisciplinary management of elderly with femur proximal extremity fracture: A patient-tailored plan from orthopaedics to rehabilitation

“…In this context, rehabilitation plays a key role in the comprehensive management of FFPE patients, taking into account the positive effects of exercise in the recovery of functional status[ 47 ] and for balance and prevention of risk of falling, which is a major determinant of refracture occurrence[ 48 ].…”

Does the association of therapeutic exercise and supplementation with sucrosomial magnesium improve posture and balance and prevent the risk of new falls?

“…The roles of magnesium in the determination of both sarcopenia and osteopenia, as well as in various mitochondrial processes involved in the production of ATP are also evident [19][20][21][22][23][24][25][26][27][28][29].…”