&lt;p&gt;Molecular epidemiology and antimicrobial resistance of invasive non-typhoidal &lt;em&gt;Salmonella&lt;/em&gt; in China, 2007–2016&lt;/p&gt;

Zhan, Zeqiang; Xu, Xuebin; Gu, Zhen; Meng, Jianghong; Wufuer, Xiayidan; Wang, Mingliu; Huang, Ming‐De; Chen, Jianhui; Jing, Chunmei; Zhou, Xiong; Zeng, Mei; Liao, Ming; Zhang, Jianmin

doi:10.2147/idr.s210961

Cited by 38 publications

(39 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increasing prevalence of antimicrobial resistance has been observed in NTS over recent decades [41]. A substantial amount of resistance to antibiotics used for NTS infections was found in the present study, and accompanied with a upward trends over the years; 81.3% of isolates were resistant to at least one of the first-line agents, and more than half (52.4%) of isolates were resistant to two or more first-line agents.…”

Section: Plos Neglected Tropical Diseasessupporting

confidence: 62%

Non-typhoidal Salmonella infections among children in a tertiary hospital in Ningbo, Zhejiang, China, 2012–2019

Ke¹,

Wen-bo²,

Liu³

et al. 2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Background Non-typhoidal Salmonella (NTS), a common cause of diarrheal enterocolitis, may also cause severe invasive diseases. Limited information on NTS infections in children is available in China. Methods We performed a retrospective study of children admitted to the Ningbo Women and Children's Hospital with culture-confirmed NTS infections between January 2012 and December 2019. Clinical and microbiological information were collected. We compared demographic, clinical and antibiotic resistance variables of invasive NTS (iNTS) infections and non-invasive NTS (non-iNTS) infections, and explored associations between hospitalizations for pediatric NTS infections and temperature and rainfall. Results A total of 166 pediatric hospitalizations due to NTS infection were identified during the 8year study period. Most of the 166 children were <5 years old (93.4%). The primary serotype was Salmonella Typhimurium (62.6%). Of 166 children with NTS infections, 11 had invasive infection. Compared to 155 children with non-iNTS infections, we found that iNTS infections were more likely to occur in infants �6 months or children with an underlying medical condition of leukemia at admission, but iNTS infections less often presented with a symptom of diarrhea (P <0.05 in all cases). The resistance rates of non-iNTS isolates to ceftazidime, ceftriaxone, cefepime, and aztreonam were significantly higher than those of iNTS isolates (P <0.05 in all cases). In addition, compared with iNTS isolates, non-iNTS isolates were significantly associated with resistance to �4 CLSI (Clinical and Laboratory Standard Institute) classes (P = 0.041, OR: 0.089, 95%

show abstract

Section: Plos Neglected Tropical Diseasessupporting

confidence: 62%

Non-typhoidal Salmonella infections among children in a tertiary hospital in Ningbo, Zhejiang, China, 2012–2019

Ke¹,

Wen-bo²,

Liu³

et al. 2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

show abstract

“…The qepA gene was previously detected in Salmonella spp. from patients with diarrhea in China, but it was absent from isolates collected from patients with diarrhea in this study (46). The copresence of the qnrB and qnrS genes, the oqxA and oqxB genes, and the qepA gene in a single Salmonella isolate is seldom reported in Europe (63).…”

Section: Discussionmentioning

confidence: 48%

“…A study of a total of 178 isolates related to human infections caused by invasive Salmonella spp. collected in five provinces of China between 2007 and 2016 revealed that 53.4% of the isolates were MDR (46). The high rates of MDR among Salmonella spp.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study on Prevalence, Serovar Diversity, Multidrug Resistance, and CTX-M-Type Extended-Spectrum β-Lactamases of Salmonella spp. from Patients with Diarrhea, Food of Animal Origin, and Pets in Several Provinces of China

Wang

Zhao

et al. 2020

Antimicrob Agents Chemother

View full text Add to dashboard Cite

A total of 2,283 Salmonella isolates were recovered from 18,334 samples, including samples from patients with diarrhea, food of animal origin, and pets, across 5 provinces of China. The highest prevalence of Salmonella spp. was detected in chicken meats (39.3%, 486/1,237). Fifteen serogroups and 66 serovars were identified, with Salmonella enterica serovars Typhimurium and Enteritidis being the most dominant. Most (85.5%, 1,952/2,283) isolates exhibited resistance to ≥1 antimicrobial, and 56.4% were multidrug resistant (MDR). A total of 222 isolates harbored extended-spectrum β-lactamases (ESBLs), and 200 of these were of the CTX-M type and were mostly detected in isolates from chicken meat and turtle fecal samples. Overall, eight blaCTX-M genes were identified, with blaCTX-M-65, blaCTX-M-123, blaCTX-M-14, blaCTX-M-79, and blaCTX-M-130 being the most prevalent. In total, 166 of the 222 ESBL-producing isolates had amino acid substitutions in GyrA (S83Y, S83F, D87G, D87N, and D87Y) and ParC (S80I), while the plasmid-mediated quinolone resistance (PMQR)-encoding genes oqxA, oqxB, qepA, qnrB, and qnrS were detected in almost all isolates. Of the 15 sequence types (STs) identified in the 222 ESBLs, ST17, ST11, ST34, and ST26 ranked among the top 5 in number of isolates. Our study revealed considerable serovar diversity and a high prevalence of the co-occurrence of MDR determinants, including CTX-M-type ESBLs, quinolone resistance-determining region (QRDR) mutations, and PMQR genes. This is the first report of CTX-M-130 Salmonella spp. from patients with diarrhea and QRDR mutations from turtle fecal samples. Our study emphasizes the importance of actions, both in health care settings and in the veterinary medicine sector, to control the dissemination of MDR, especially the CTX-M-type ESBL-harboring Salmonella isolates.

show abstract

“…In severe cases of salmonellosis, antibiotics are typically prescribed for treatment; however, the emergence of multidrug-resistant (MDR) S. enterica strains has raised global concern, due to an increase in the mortality rate of infected patients ( Gong et al, 2019 ; Zhan et al, 2019 ). In particular, extended-spectrum beta-lactamase-producing Salmonella strains have been frequently isolated from food animals in many countries ( Zhao et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China

et al. 2021

View full text Add to dashboard Cite

Salmonella enterica remains one of the leading causes of foodborne bacterial disease. Retail meat is a major source of human salmonellosis. However, comparative genomic analyses of S. enterica isolates from retail meat from different sources in China are lacking. A total of 341 S. enterica strains were isolated from retail meat in sixteen districts of Beijing, China, at three different time points (January 1st, May 1st, and October 1st) in 2017. Comparative genomics was performed to investigate the genetic diversity, virulence and antimicrobial resistance gene (ARG) profiles of these isolates. The most common serotype was S. Enteritidis (203/341, 59.5%), which dominated among isolates from three different time points during the year. Laboratory retesting confirmed the accuracy of the serotyping results predicted by the Salmonella In Silico Typing Resource (SISTR) (96.5%). The pangenome of the 341 S. enterica isolates contained 13,931 genes, and the core genome contained 3,635 genes. Higher Salmonella phage 118970 sal3 (219/341, 64.2%) and Gifsy-2 (206/341, 60.4%) prevalence contributed to the diversity of the accessory genes, especially those with unknown functions. IncFII(S), IncX1, and IncFIB(S) plasmid replicons were more common in these isolates and were major sources of horizontally acquired foreign genes. The virulence gene profile showed fewer virulence genes associated with type III secretion systems in certain isolates from chicken. A total of 88 different ARGs were found in the 341 isolates. Three beta-lactamases, namely, blaCTX–M–55 (n = 15), blaCTX–M–14 (n = 11), and blaCTX–M–65 (n = 11), were more prevalent in retail meats. The emergence of qnrE1 and blaCTX–M–123 indicated a potential increase in the prevalence of retail meats. After the prohibition of colistin in China, three and four isolates were positive for the colistin resistance genes mcr-1.1 and mcr-9, respectively. Thus, we explored the evolution and genomic features of S. enterica isolates from retail meats in Beijing, China. The diverse ARGs of these isolates compromise food security and are a clinical threat.

show abstract

<p>Molecular epidemiology and antimicrobial resistance of invasive non-typhoidal <em>Salmonella</em> in China, 2007–2016</p>

Cited by 38 publications

References 39 publications

Non-typhoidal Salmonella infections among children in a tertiary hospital in Ningbo, Zhejiang, China, 2012–2019

Non-typhoidal Salmonella infections among children in a tertiary hospital in Ningbo, Zhejiang, China, 2012–2019

Epidemiological Study on Prevalence, Serovar Diversity, Multidrug Resistance, and CTX-M-Type Extended-Spectrum β-Lactamases of Salmonella spp. from Patients with Diarrhea, Food of Animal Origin, and Pets in Several Provinces of China

Genomic Characterization of Salmonella enterica Isolates From Retail Meat in Beijing, China

Contact Info

Product

Resources

About