&lt;p&gt;MIR155HG Knockdown Inhibited the Progression of Cervical Cancer by Binding SRSF1&lt;/p&gt;

Shen, Lei; Li, Yuancheng; Hu, Guiying; Huang, Yihong; Song, Xinli; Yu, Sheng; Xu, Xiaoyuan

doi:10.2147/ott.s267594

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…At present, some researchers have found that MIR155HG played an important role in many cancers. Shen et al [30] reported that MIR155HG silencing can inhibit the progress of cervical cancer by combining with SRSF1. Therefore, the author speculated that MIR155HG may be used as a potential new therapeutic target for cervical cancer treatment [30].…”

Section: Discussionmentioning

confidence: 99%

“…Shen et al [30] reported that MIR155HG silencing can inhibit the progress of cervical cancer by combining with SRSF1. Therefore, the author speculated that MIR155HG may be used as a potential new therapeutic target for cervical cancer treatment [30]. Besides, Qin et al [19] showed that the tumor-promoting effect of MIR155HG was caused by the negative regulation of miR-802 in pancreatic cancer cells.…”

Section: Discussionmentioning

confidence: 99%

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The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

Jia¹,

Zhou²,

Ji³

et al. 2023

Digestion

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Introduction: MIR155HG has been found to play an important role in malignant tumors, but little research has been done on its association with esophageal cancer (ESCC). The aim of this study was to investigate the relationship between MIR155HG polymorphisms and ESCC susceptibility in the Chinese Han population. Methods: 511 ESCC patients and 487 healthy controls were selected for this study. All subjects were genotyped using the Agena MassARRAY platform. We assessed the association between seven single nucleotide polymorphisms (SNPs) of the MIR155HG and ESCC risk by genetic model analysis. The false discovery rate (FDR) test and Bonferroni correction were usually used to detect false positives for the results. Meanwhile, the interaction between SNPs was analyzed by multifactor dimensionality reduction software to predict the ESCC risk. Results: The C allele of rs4143370 and the A allele of rs34904192 in MIR155HG can increase the risk of ESCC (odds ratio (OR) = 1.33, p = 0.024; OR = 1.30, p = 0.013). Furthermore, rs4143370 and rs34904192 were associated with an increased risk of ESCC. Stratified analysis showed that MIR155HG SNPs (rs4143370 and rs34904192) significantly increased ESCC risk in males. MIR155HG SNPs (rs4143370, rs34904192, and rs928883) were also strongly associated with an increased risk of ESCC in people aged >64 years. In addition, haplotype analysis of the seven SNPs of the MIR155HG showed that the CC haplotype was associated with ESCC risk (OR = 1.34, p = 0.024). Conclusion: This study revealed that MIR155HG SNPs were associated with an increased risk of ESCC. The results provided clues for clarifying the role of MIR155HG in ESCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

Jia¹,

Zhou²,

Ji³

et al. 2023

Digestion

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“…Ten pairs with prognostic values were identi ed by univariate Cox regression analysis. Some lncRNAs of the 10 pairs have been reported to be critically involved in tumorigenesis, such as USP30-AS1 [34][35][36] , HLA-DQB1-AS1 37,38 , and MIR155HG [39][40][41] . Based on the LASSO regression analysis, we constructed a risk assessment model composed of 3 DEirlncRNA pairs (USP30-AS1|SERPINB9P1, AL731567.1|AC004585.1, AC110995.1|AC007991.2).…”

Section: Discussionmentioning

confidence: 99%

A Novel Immune-Related LncRNA Pair Model to Predict the Prognosis of Triple-Negative Breast Cancer

Fan

Peng

et al. 2023

Preprint

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Background Breast cancer (BC) is the most prevalent cancer type and is the principal cause of cancer-related death in women. Anti-PD-1/PD-L1 immunotherapy has shown promising activity in metastatic TNBC, but the potential factors affecting its efficacy have not been elucidated. Immune-related long noncoding RNAs (irlncRNAs) have been reported to be involved in immune escape to influence the carcinogenic process through the PD-1/PD-L1 signaling pathway. Therefore, exploring the potential regulatory mechanism of irlncRNAs in PD-1/PD-L1 immunotherapy in TNBC is of great importance. Methods In the current study, we retrieved transcriptome profiling data from The Cancer Genome Atlas (TCGA) and identified differentially expressed irlncRNA (DEirlncRNA) pairs. Least absolute shrinkage and selection operator (LASSO) regression analysis was performed to construct a risk assessment model. Results Receiver operating characteristic (ROC) curve analysis indicated that the risk model may serve as a potential prediction factor in TNBC patients. Clinical stage and risk score proved to be independent prognostic predictors by univariate and multivariate Cox regression analyses. Subsequently, we investigated the correlation between the risk model and tumor-infiltrating immune cells and immune checkpoints. Finally, we identified USP30-AS1 through the StarBase and MEM databases, predicted the potential target genes of USP30-AS1, and then discovered that these target genes were closely associated with immune responses. Conclusion Although the current study did not investigate the specific mechanism by in vivo and in vitro experiments, we constructed a risk assessment model by immune-related lncRNA pairs regardless of expression levels, which has the potential to predict the efficacy of anti-PD-1/PD-L1 immunotherapy and provide a novel strategy for TNBC treatment.

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“…Long noncoding RNA (lncRNA) is a non‐protein coding RNA molecule with a length of 200–100,000 nt mainly involved in transcription or post‐transcriptional regulation, protein transport and mRNA degradation 15,16 . The miR‐155 host gene (MIR155HG) (NCBI Reference Sequence: NR_132107.1) is a lncRNA involved in apoptosis, inflammation and tumorigenesis 17,18 . It has been reported that MIR155HG promotes the migration and invasion of gastric cancer cells 19 .…”

Section: Introductionmentioning

confidence: 99%

Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205

Bai,

Qi,

Cai

et al. 2024

J Cellular Molecular Medi

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Coronary artery bypass grafting (CABG) is an effective treatment for coronary heart disease, with vascular transplantation as the key procedure. Intimal hyperplasia (IH) gradually leads to vascular stenosis, seriously affecting the curative effect of CABG. Mesenchymal stem cells (MSCs) were used to alleviate IH, but the effect was not satisfactory. This work aimed to investigate whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of IH and to elucidate the role of the competing endogenous RNA (ceRNA). The effect of MIR155HG on MSCs function was investigated, while the proteins involved were assessed. IH was detected by HE and Van Gieson staining. miRNAs as the target of lncRNA were selected by bioinformatics analysis. qRT‐PCR and dual‐luciferase reporter assay were performed to verify the binding sites of lncRNA‐miRNA. The apoptosis, Elisa and tube formation assay revealed the effect of ceRNA on the endothelial protection of MIR155HG‐MSCs. We observed that MIR155HG improved the effect of MSCs on IH by promoting viability and migration. MIR155HG worked as a sponge for miR‐205. MIR155HG/miR‐205 significantly improved the function of MSCs, avoiding apoptosis and inducing angiogenesis. The improved therapeutic effects of MSCs on IH might be due to the ceRNA role of MIR155HG/miR‐205.

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<p>MIR155HG Knockdown Inhibited the Progression of Cervical Cancer by Binding SRSF1</p>

Cited by 11 publications

References 21 publications

The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population

A Novel Immune-Related LncRNA Pair Model to Predict the Prognosis of Triple-Negative Breast Cancer

Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205

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