&lt;p&gt;Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study&lt;/p&gt;

Gaber, Dalia A; Alhawas, Hessah S.; Alfadhel, Fatimah A; Abdoun, Siham A; Alsubaiyel, Amal M.; Alsawi, Rehab M

doi:10.2147/dddt.s285522

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…Furthermore, complementary analysis by Korsmeyer-Peppas and Weibull models confirmed a Fickian mechanism, since n is < 0.5 and β is ≤ 0.75, respectively, illuminating that the drug release was extensively controlled by diffusion. It was reported that other drugs loaded in LPHNPs followed similar kinetic patterns 50 .…”

Section: Resultsmentioning

confidence: 93%

Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis

Awadeen,

Boughdady,

Zaghloul

et al. 2023

Sci Rep

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Fisetin (FST) is a naturally occurring flavonol that has recently emerged as a bioactive phytochemical with an impressive array of biological activities. To the author knowledge, boosting the activity of FST against severe acute pancreatitis (SAP) through a nanostructured delivery system (Nanophytomedicine) has not been achieved before. Thereupon, FST-loaded lipid polymer hybrid nanoparticles (FST-loaded LPHNPs) were prepared through conjoined ultrasonication and double emulsion (w/o/w) techniques. Comprehensive in vitro and in vivo evaluations were conducted. The optimized nanoparticle formula displayed a high entrapment efficiency % of 61.76 ± 1.254%, high loading capacity % of 32.18 ± 0.734, low particle size of 125.39 ± 0.924 nm, low particle size distribution of 0.357 ± 0.012, high zeta potential of + 30.16 ± 1.416 mV, and high mucoadhesive strength of 35.64 ± 0.548%. In addition, it exhibited a sustained in vitro release pattern of FST. In the in vivo study, oral pre-treatment of FST-loaded LPHNPs protected against l-arginine induced SAP and multiple organ injuries in rats compared to both FST alone and plain LPHNPs, as well as the untreated group, proven by both biochemical studies, that included both amylase and lipase activities, and histochemical studies of pancreas, liver, kidney and lungs. Therefore, the study could conclude the potential efficacy of the novel phytopharmaceutical delivery system of FST as a prophylactic regimen for SAP and consequently, associated multiple organ injuries.

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Section: Resultsmentioning

confidence: 93%

Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis

Awadeen,

Boughdady,

Zaghloul

et al. 2023

Sci Rep

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“…A comparative study aimed at investigating the release and bioavailability of amoxicillin in mini-tablet and lipid/polymer form. 100 Insulin-magnesium containing tablets were not only utilized as micromotors but also capable of adsorbed onto mucus. Such an interface feature limits the nanoparticle entrapment in mucus layers.…”

Section: Nanoparticle-based Tablets a Tablet Incorporating Gold Nanop...mentioning

confidence: 99%

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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“…However, some of these polymers have been developed for specific targets, 46,47 and they may not effectively control polymicrobial infections in highly heterogeneous and diverse microenvironments, 48 such as peri‐implantitis. In fact, previous evidence has shown a limited antimicrobial effect of nanoparticles containing AMX and MTZ 49–52 . Fast drug release is another problem associated with these biomaterials.…”

Section: New Approaches To Peri‐implantitis Treatment: Bioengineering...mentioning

confidence: 99%

“…In fact, previous evidence has shown a limited antimicrobial effect of nanoparticles containing AMX and MTZ. [49][50][51][52] Fast drug release is another problem associated with these biomaterials.…”

Section: New Approaches To Peri-implantitis Treatment: Bioengineering...mentioning

confidence: 99%

Unraveling the effectiveness of antibiotics for peri‐implantitis treatment: A scoping review

Feres

Martins

Souza

et al. 2023

Clin Implant Dent Rel Res

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Background Antibiotics are the most effective adjuncts in the treatment of periodontitis. However, the benefits of these agents in treating peri‐implantitis are still debatable and demand further analysis. Purpose The aim of this review was to critically appraise the literature on the use of antibiotics to treat peri‐implantitis, with the ultimate goal of supporting evidence‐based clinical recommendations, defining gaps in knowledge and guiding future studies on this topic. Methods A systematized literature search was conducted in MEDLINE/PubMed and Cochrane Library databases for randomized clinical trials (RCTs) on patients with peri‐implantitis treated by mechanical debridement‐only or with adjunctive use of local or systemic antibiotics. Clinical and microbiological data were extracted from the RCTs included. The findings were critically reviewed, interpreted, and discussed. An overview of antibiotic‐loaded dental implant materials in peri‐implantitis treatment was also provided. Results Twelve RCTs testing local/systemic antibiotics were included. Although not always statistically significant, all antibiotic‐treated groups had greater reductions in mean PD than those treated by mechanical debridement‐only. The only clinically relevant antibiotic protocol supported by one RCT with low risk of bias and long‐lasting benefits was systemic metronidazole (MTZ). Studies using ultrasonic debridement reported better outcomes. No RCTs to date have tested MTZ‐only or with amoxicillin (AMX) as adjuncts to open‐flap implant debridement. In vitro/animal studies suggested that biomaterials with antimicrobial properties are promising to treat peri‐implantitis. Conclusion There are insufficient data to support a particular evidence‐based antibiotic protocol to treat peri‐implantitis using surgical or nonsurgical therapy, but some conclusions may be drawn. Systemic MTZ adjunct to ultrasonic debridement is an effective protocol to improve the outcomes of nonsurgical treatment. Future studies should assess the clinical and microbiological effects of MTZ and MTZ + AMX as adjuncts to optimal nonsurgical implant decontamination protocols or open‐flap debridement. In addition, new locally delivered drugs and antibiotic‐loaded surfaces should be assessed by RCTs.

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<p>Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study</p>

Cited by 9 publications

References 48 publications

Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis

Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Unraveling the effectiveness of antibiotics for peri‐implantitis treatment: A scoping review

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