2019
DOI: 10.2147/jir.s197917
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<p>Microvascular stasis and hemolysis: coincidence or causality?</p>

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Cited by 4 publications
(2 citation statements)
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“…Acute hemolysis, through free hemoglobin, may cause microvascular stasis in the visceral circulation that increases the risk of coagulation activation [ 43 ]. However, according to an in vivo study in mice, hemoglobin is indirectly responsible for the activation of this process through the release of its oxygen-binding domain heme.…”
Section: Pathophysiology Of Thrombosis In Immune Mediated Hemolysismentioning
confidence: 99%
“…Acute hemolysis, through free hemoglobin, may cause microvascular stasis in the visceral circulation that increases the risk of coagulation activation [ 43 ]. However, according to an in vivo study in mice, hemoglobin is indirectly responsible for the activation of this process through the release of its oxygen-binding domain heme.…”
Section: Pathophysiology Of Thrombosis In Immune Mediated Hemolysismentioning
confidence: 99%
“…As such, thrombotic events contribute to a variety of clinical sequelae encompassing ischemic heart disease and stroke [ 2 , 6 , 11 ]. Moreover, several hemolytic conditions, such as sickle cell disease (SCD) [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ], hemolytic uremic syndrome [ 25 , 26 ], hemoglobinuria [ 27 , 28 ], hemolytic transfusion reactions [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], hemorrhage [ 33 , 37 , 38 , 39 , 40 , 41 , 42 ], and cardiac surgery [ 43 , 44 ], were reported to manifest thrombotic complications as thrombosis, hypercoagulability, and vasculopathy [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ]. In adult SCD patients, venous thromboembolism (VTE) is even one of the leading causes of death [ 57 , 58 ].…”
Section: Introductionmentioning
confidence: 99%