&lt;p&gt;Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study&lt;/p&gt;

Liu, Jinghong; Ma, Qiang; Xu, Yong; Chen, Xing; Pan, Chen‐Wei

doi:10.2147/dmso.s278542

Cited by 7 publications

(4 citation statements)

References 41 publications

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Section: Discussionmentioning

confidence: 99%

“…The association between hyperuricemia and MetS has been explored in many cross-sectional studies, but prospective studies are rare ( 7 – 9 , 19 , 20 ). Some studies suggest that MetS can increase the incidence of hyperuricemia ( 19 – 21 ); however, others suggest that hyperuricemia should be included as a component of MetS ( 7 ). The latest study that reviewed the China Health and Retirement Longitudinal Study (CHARLS) data from 2011 to 2015 concluded that there is a bidirectional relationship between MetS and hyperuricemia, which is in agreement with our research ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

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Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

et al. 2022

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ObjectiveThis study was a prospective assessment of the epidemiological characteristics of metabolic syndrome (MetS) in cities in Northeast China. We explored the factors that affect the occurrence and outcome of MetS according to sex.Design and MethodsThis was a longitudinal survey assessing MetS status among 750 urban community residents in China. At baseline, the intra-abdominal fat area was measured by MRI, simple anthropometric parameters (body mass index (BMI), waist circumference (WC), etc.) were used to evaluate fat distribution; blood pressure and blood lipid profile were measured; an oral glucose tolerance test (OGTT) was used to detect blood glucose; questionnaires were used to investigate lifestyles. Follow-up was conducted after 1.5 years (follow-up rate was 66.93%) to analyze the incidence of MetS and the influencing factors of MetS outcomes according to sex.ResultsThe 1.5-year cumulative incidence of MetS in the survey area was 25.40%. Men with visceral obesity were more likely to develop MetS than those with subcutaneous obesity (OR=9.778, p<0.05). Increased BMI (OR=1.379) and blood uric acid (BUA)>416 mmol/L (OR=2.318) were associated with the occurrence of MetS in men (all p<0.05). At the initial visit, BUA>356.9 mmol/L (OR=3.538), increased BMI (OR=1.212), and increased HbA1c (OR=2.577) were associated with the occurrence of MetS in women (all p<0.05). After 1.5 years, 25.37% of MetS patients no longer had MetS. Elevated diastolic blood pressure (DBP) (OR=1.097) and increased visceral fat (OR=1.023) at the initial visit made men with MetS less likely to recover from MetS (all p<0.05). Higher High-density lipoprotein cholesterol (HDL-C) at the initial visit made women with MetS more likely to recover from MetS (β: -3.509, OR=0.003, p<0.05).ConclusionThere are different risk factors for MetS in different genders. Hyperuricemia is a risk factor for the onset of MetS in both men and women.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

et al. 2022

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“…A recent report from China showed that the prevalence rates of HUA increased steadily from 8.5 to 18.4% from 2000 to 2017 (4). Previous studies have suggested that lifestyle (especially diet) and history of cardiovascular disease were related to the incidence of HUA (5)(6)(7)(8). Of particular concern is that diet might be the most important and cost-effective factor that can be used to modify the risk of HUA (9).…”

Section: Introductionmentioning

confidence: 99%

Dietary pattern and risk of hyperuricemia: an updated systematic review and meta-analysis of observational studies

Wen,

Wei,

Sun

et al. 2024

Front. Nutr.

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ObjectivesThe associations of posteriori dietary patterns with the risk of hyperuricemia (HUA) are contradictory. Several fair-quality observational studies with inconsistent results have been published following a prior review. Herein, we carried out an updated systematic review and meta-analysis to quantitatively analyze the aforementioned relationships.MethodsOur analysis protocol has been registered with PROSPEPO (Number: CRD42022376745). English publications were searched in Embase, PubMed, and Web of Science from inception to January 1, 2024. Summary odds ratio (OR) and 95% confidence intervals (CIs) were calculated by a random-effects model. We also conducted subgroup, sensitivity, and meta-regression analyses and publication bias assessments.ResultsThirteen studies with a total of 163,192 participants were included in the current meta-analysis. Our finding revealed that the plant-based pattern was linked with a 17% decreased risk of HUA (OR = 0.83, 95%CI = 0.72–0.94, I2 = 72.9%, n = 10). There was no evidence of publication bias in the present analysis. The results of subgroup analyses were generally consistent with the main findings. In meta-regression analyses, no evidence of heterogeneity was detected in the subgroups. Furthermore, our analyses indicated that the animal-based food pattern (OR = 1.36, 95%CI = 1.25–1.47, I2 = 26.7%, n = 11) and sweet food pattern (OR = 1.24, 95%CI = 1.06–1.46, I2 = 0, n = 2) was related to an increased risk of HUA.ConclusionThe plant-based pattern is inversely correlated with HUA risk, whereas animal-based food patterns and sweet food patterns are positively correlated with HUA risk.

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“…It is defined as a cluster of disorders and risk factors for cardiovascular disease, including abdominal obesity, hyperglycemia (including impaired glucose tolerance and diagnosed diabetes), dyslipidemia, and elevated blood pressure. Many studies have demonstrated a strong association between metabolic syndrome or metabolic components and the risk for subsequent development of type 2 diabetes (4-8), cardiovascular disease (9)(10)(11)(12)(13), hyperuricemia, gout (14)(15)(16), and CKD (17)(18)(19)(20)(21). These factors interact as both cause and effect, and the multiple mechanisms involved in the development of CKD in patients with metabolic syndrome have not been well-established.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Risk Factors Associated With Chronic Kidney Disease in a Middle-Aged and Elderly Taiwanese Population: A Cross-Sectional Study

Chen

Hsu

et al. 2021

Front. Med.

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Background: This study aimed to quantify the proportion of participants with chronic kidney disease (CKD) and associated metabolic risk factors in a middle-aged and elderly population in Guishan District, Taoyuan City, Taiwan.Methods: This cross-sectional study enrolled residents aged 50–90 years living in one community. All participants received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples collected for laboratory testing. CKD was defined as the presence of kidney damage (urine albumin-creatinine ratio ≥30 mg/g) or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Multiple logistic regression models were used to evaluate the risk factors associated with CKD.Results: A total of 400 participants were enrolled. The overall proportion of participants with CKD was 20.5% (95% confidence interval [CI]: 16.54–24.46%). The proportions of participants with CKD among those aged 50–64, 65–74, and 75 years and over were 17.7, 18.8, and 35.7%, respectively (p = 0.01). Multiple logistic regression model revealed that elevated blood pressure (odds ratio [OR] = 2.23, 95% CI: 1.16–4.30), hyperglycemia (OR = 2.87, 95% CI: 1.64–5.00), hyperuricemia (OR = 1.38, 95% CI: 1.14–1.69), and metabolic syndrome (OR = 2.30, 95% CI: 1.31–4.06) were significantly associated with CKD.Conclusions: The prevalence of CKD in the study population was high. Hypertension, hyperglycemia, hyperuricemia, and metabolic syndrome are significantly associated with CKD in a middle-aged and elderly population in Taiwan.

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<p>Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study</p>

Cited by 7 publications

References 41 publications

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

Dietary pattern and risk of hyperuricemia: an updated systematic review and meta-analysis of observational studies

Metabolic Risk Factors Associated With Chronic Kidney Disease in a Middle-Aged and Elderly Taiwanese Population: A Cross-Sectional Study

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