&lt;p&gt;&lt;sup&gt;68&lt;/sup&gt;Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation&lt;/p&gt;

Hajiramezanali, Maliheh; Atyabi, Fatemeh; Mosayebnia, Mona; Akhlaghi, Mehdi; Geramifar, Parham; Jalilian, Amir Reza; Mazidi, Seyed Mohammad; Yousefnia, Hassan; Shahhosseini, Soraya; Beiki, Davood

doi:10.2147/ijn.s195223

Cited by 49 publications

(29 citation statements)

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“… 36 , 37 DOTA-BBN conjugated onto trimethyl chitosan has been proposed for subsequent conjugation with superparamagnetic iron oxide nanoparticles (SPIONs) for applications as magnetic resonance imaging (MRI) for breast cancer diagnosis. 38 Overall, the aforementioned approaches allow the creation of targeted nanoradiopharmaceuticals to enhance diagnostic and therapeutic efficacies of various types of human cancers with minimal side effects to surrounding normal cells/tissues.…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Chitosan Conjugated DOTA-Bombesin Peptide Capped Gold Nanoparticles as a Targeted Therapeutic Agent for Prostate Cancer

Tangthong¹,

Piroonpan²,

Thipe³

et al. 2021

NSA

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Introduction Functionalization of water-soluble chitosan (WSCS) nanocolloids with, gold nanoparticles (AuNPs), and LyslLys3 (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-bombesin 1–14 (DOTA-BBN) peptide affords an innovative pathway to produce prostate tumor cell-specific nanomedicine agents with potential applications in molecular imaging and therapy. Methods The preparation involves the production and full characterization of water-soluble chitosan (WSCS), via gamma (γ) rays (80 kGy) irradiation, followed by DOTA-BBN conjugation for subsequent use as an effective template toward the synthesis of tumor cell-specific AuNPs-WSCS-DOTA-BBN. Results The WSCS-DOTA-BBN polymeric nanoparticles (86 ± 2.03 nm) served multiple roles as reducing and stabilizing agents in the overall template synthesis of tumor cell-targeted AuNPs. The AuNPs capped with WSCS and WSCS-DOTA-BBN exhibited average Au-core diameter of 17 ± 8 nm and 20 ± 7 nm with hydrodynamic diameters of 56 ± 1 and 67± 2 nm, respectively. The AuNPs-WSCS-DOTA-BBN showed optimum in vitro stability in biologically relevant solutions. The targeted AuNPs showed selective affinity toward GRP receptors overexpressed in prostate cancer cells (PC-3 and LNCaP). Discussion The AuNPs-WSCS-DOTA-BBN displayed cytotoxicity effects against PC-3 and LNCaP cancer cells, with concomitant safety toward the HAECs normal cells. The AuNPs-WSCS-DOTA-BBN showed synergistic targeting toward tumor cells with selective cytotoxicity of AuNPs towards PC-3 and LNCaP cells. Our investigations provide compelling evidence that AuNPs functionalized with WSCS-DOTA-BBN is an innovative nanomedicine approach for use in molecular imaging and therapy of GRP receptor-positive tumors. The template synthesis of AuNPs-WSCS-DOTA-BBN serves as an excellent non-radioactive surrogate for the development of the corresponding 198 AuNPs theragnostic nanoradiopharmaceutical for use in cancer diagnosis and therapy.

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Section: Introductionmentioning

confidence: 99%

Water-Soluble Chitosan Conjugated DOTA-Bombesin Peptide Capped Gold Nanoparticles as a Targeted Therapeutic Agent for Prostate Cancer

Tangthong¹,

Piroonpan²,

Thipe³

et al. 2021

NSA

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“…Furthermore, 64 Cu- and 68 Ga-labeled NPs functionalized with a peptide were reported in several papers too. The multifunctional gold nanorod nanocarriers were covalently bound with doxorubicin and subsequently conjugated to [ 64 Cu]Cu-NOTA-RGD [ 127 ]; [ 64 Cu]Cu-sulphide NPs conjugated to the pegylated bombesin [ 128 ]; [ 68 Ga]Ga-DOTA-somatostatin and neurotensin analogues to gold NPs [ 129 ]; [ 68 Ga]Ga-NODAGA-bombesin to the polyethylene glycol-coated ultra-small superparamagnetic iron-oxide nanoparticles [ 130 ]; and [ 68 Ga]Ga-DOTA-bombesin analogue conjugated to the N,N,N -trimethyl chitosan-coated magnetic nanoparticles for a breast cancer detection [ 131 ].…”

Section: Complexes and Radiolabeling Approaches For Target-specifimentioning

confidence: 99%

Advances in Development of Radiometal Labeled Amino Acid-Based Compounds for Cancer Imaging and Diagnostics

Mikulová

Mikuš

2021

Pharmaceuticals

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Radiolabeled biomolecules targeted at tumor-specific enzymes, receptors, and transporters in cancer cells represent an intensively investigated and promising class of molecular tools for the cancer diagnosis and therapy. High specificity of such biomolecules is a prerequisite for the treatment with a lower burden to normal cells and for the effective and targeted imaging and diagnosis. Undoubtedly, early detection is a key factor in efficient dealing with many severe tumor types. This review provides an overview and critical evaluation of novel approaches in the designing of target-specific probes labeled with metal radionuclides for the diagnosis of most common death-causing cancers, published mainly within the last three years. Advances are discussed such traditional peptide radiolabeling approaches, and click and nanoparticle chemistry. The progress of radiolabeled peptide based ligands as potential radiopharmaceuticals is illustrated via novel structure and application studies, showing how the molecular modifications reflect their binding selectivity to significant onco-receptors, toxicity, and, by that, practical utilization. The most impressive outputs in categories of newly developed structures, as well as imaging and diagnosis approaches, and the most intensively studied oncological diseases in this context, are emphasized in order to show future perspectives of radiometal labeled amino acid-based compounds in nuclear medicine.

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“…In this process, radioactive materials utilize the hydroxyl, methyl, and carbonyl groups present in most polymers and react directly with the surface polymer of polymeric NPs. In the case of 99m Tc-polymeric NPs, using the chemical coordination from the 99m Tc, a very stable octahedral geometry is made, providing in vivo stability (Dewanjee, 1990 ; Cheng et al., 2017 ; Chakravarty et al., 2017 ; Ni et al., 2018 ; Hajiramezanali et al., 2019 ; Sun et al., 2019 ). It is important to observe that chelate-free methodologies showed no disruptive effect on the physical and biochemical properties of the polymeric NP.…”

Section: Radioactive Polymeric Nanoparticles For Imaging and Therapymentioning

confidence: 99%

“…The problem with this methodology is multiple radiolabeling steps with limited radiochemical yields. The disadvantage of introducing a prosthetic group (the non-protein acid constituent of conjugated protein) or metal ion chelate is handling a highly toxic NP (Ni et al., 2018 ; Hajiramezanali et al., 2019 ; Sun et al., 2019 ). The coated modified nanoparticle method uses functional groups on the surface of polymeric NPs, where it is possible to use chelators as hydrazinonicotinamide (HYNIC) to bind radioactive species to the NP’s surface.…”

Section: Radioactive Polymeric Nanoparticles For Imaging and Therapymentioning

confidence: 99%

See 1 more Smart Citation

Radioactive polymeric nanoparticles for biomedical application

Wu¹,

Helal-Neto

Matos

et al. 2020

Drug Delivery

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Nowadays, emerging radiolabeled nanosystems are revolutionizing medicine in terms of diagnostics, treatment, and theranostics. These radionuclides include polymeric nanoparticles (NPs), liposomal carriers, dendrimers, magnetic iron oxide NPs, silica NPs, carbon nanotubes, and inorganic metal-based nanoformulations. Between these nano-platforms, polymeric NPs have gained attention in the biomedical field due to their excellent properties, such as their surface to mass ratio, quantum properties, biodegradability, low toxicity, and ability to absorb and carry other molecules. In addition, NPs are capable of carrying high payloads of radionuclides which can be used for diagnostic, treatment, and theranostics depending on the radioactive material linked. The radiolabeling process of nanoparticles can be performed by direct or indirect labeling process. In both cases, the most appropriate must be selected in order to keep the targeting properties as preserved as possible. In addition, radionuclide therapy has the advantage of delivering a highly concentrated absorbed dose to the targeted tissue while sparing the surrounding healthy tissues. Said another way, radioactive polymeric NPs represent a promising prospect in the treatment and diagnostics of cardiovascular diseases such as cardiac ischemia, infectious diseases such as tuberculosis, and other type of cancer cells or tumors.

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<p><sup>68</sup>Ga-radiolabeled bombesin-conjugated to trimethyl chitosan-coated superparamagnetic nanoparticles for molecular imaging: preparation, characterization and biological evaluation</p>

Cited by 49 publications

References 53 publications

Water-Soluble Chitosan Conjugated DOTA-Bombesin Peptide Capped Gold Nanoparticles as a Targeted Therapeutic Agent for Prostate Cancer

Water-Soluble Chitosan Conjugated DOTA-Bombesin Peptide Capped Gold Nanoparticles as a Targeted Therapeutic Agent for Prostate Cancer

Advances in Development of Radiometal Labeled Amino Acid-Based Compounds for Cancer Imaging and Diagnostics

Radioactive polymeric nanoparticles for biomedical application

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