&lt;p&gt;Long Noncoding RNA HCP5 Regulates Pancreatic Cancer Gemcitabine (GEM) Resistance By Sponging Hsa-miR-214-3p To Target HDGF&lt;/p&gt;

Liu, Yunfei; Wang, Jiale; Luo, Dong; Li, Xia; Zhu, Hongwei; Li, Zhiqiang; Xiao, Yu

doi:10.2147/ott.s222703

Cited by 56 publications

(39 citation statements)

References 27 publications

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“…[ [38][39][40] Cholangiocarcinoma High HDGF expression levels were significantly associated with poorer overall survival in patients with hilar cholangiocarcinoma. The expression of HDGF was also reported as an independent prognostic factor for extrahepatic cholangiocarcinoma.…”

Section: Malignant Digestive System Diseases Main Findings Reference(s)mentioning

confidence: 99%

“…Recently, HDGF was reported to be induced by transforming growth factor (TGF)-β1, and to contribute to the growth of pancreatic cancer cells through the anti-apoptotic effects on pancreatic stellate cells [39]. In addition, HDGF was suggested to be related to gemcitabine resistance in pancreatic cancer [40].…”

Section: Hdgf In Pancreatic Cancermentioning

confidence: 99%

“…Recently, non-coding RNAs, such as microRNAs and long non-coding RNAs (lncRNAs), which modulate the function of the target genes, have been shown to have an important role in several diseases [77,78]. Indeed, various microRNAs [40,61,62,[64][65][66][67]69,72] and lncRNAs [49,61,69,71,73] have been suggested to be involved in the regulation of the functions of HDGF, findings that may support the development of HDGF-targeting therapies. For instance, lncRNA HLA complex P5 (lnc HCP5) was reported to cause gemcitabine resistance in pancreatic cancer cells, through the upregulation of miR-214-3p and its target gene, HDGF [40].…”

Section: Future Perspectivesmentioning

confidence: 99%

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Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

Enomoto

Nakamura

Nishikawa

et al. 2020

IJMS

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Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins were identified, and these proteins are considered to be members of a new gene family. HDGF has a growth-stimulating role, an angiogenesis-inducing role, and a probable anti-apoptotic role. HDGF is ubiquitously expressed in non-cancerous tissues, and participates in organ development and in the healing of damaged tissues. In addition, the high expression of HDGF was reported to be closely associated with unfavorable clinical outcomes in several malignant diseases. Thus, HDGF is considered to contribute to the development and progression of malignant disease. We herein provide a brief overview of the factor and its functions in relation to benign and malignant cells. We also describe its possible role as a target molecule for digestive malignancies.

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Section: Malignant Digestive System Diseases Main Findings Reference(s)mentioning

confidence: 99%

Section: Hdgf In Pancreatic Cancermentioning

confidence: 99%

Section: Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

Enomoto

Nakamura

Nishikawa

et al. 2020

IJMS

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“…In fact, lncRNAs are expressed not only in the nucleus but also in the cytoplasm. Many studies have demonstrated that lncRNAs participate in the regulation of various physiological and pathological processes in diseases by modulating the function of their target miRNAs (Liu et al, 2019). Different expression levels of lncRNAs can be seen circulating in the blood or tissues of patients with different diseases, including tumors, cardiovascular diseases, and nervous system and immune system diseases.…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA TCONS_00016406 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating the miR-687/PTEN Pathway

et al. 2020

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Acute kidney injury (AKI) is a common and serious complication of sepsis accompanied by kidney dysfunction resulting from various etiologies and pathophysiological processes. Unfortunately, there is currently no ideal therapeutic strategy for AKI. Numerous studies have confirmed that long noncoding RNAs (lncRNAs) play important regulatory roles in the pathogenesis of sepsis-associated AKI. In this study, lncRNA TCONS_00016406 (termed lncRNA 6406), a novel lncRNA identified by using TargetScan, was significantly downregulated in the kidney tissues of mice with sepsis-associated AKI. This study aimed to explore the role of lncRNA 6406 in lipopolysaccharide (LPS)-induced AKI and its potential molecular mechanism. The models of sepsis-induced AKI (called LPS-induced AKI models) in mice and cell lines were established with male C57BL/6 mice and renal tubular epithelial (PTEC) cells, respectively. Twenty-four hours after LPS administration, kidneys and cell samples were collected after various treatments to examine the alterations in the lncRNA 6406 levels and to evaluate the effects on LPS-induced inflammation, oxidative stress, and apoptosis through real-time PCR (RT-PCR) analysis, western blotting, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. The results revealed that lncRNA 6406 could significantly attenuate LPS-induced AKI, as shown by the alleviation of inflammation, the suppression of oxidative stress and the inhibition of apoptosis. Mechanistically, a luciferase reporter assay and additional research showed that lncRNA 6406 functioned as a ceRNA to sponge miRNA-687, thereby modulating LPS-stimulated AKI by targeting the miR-687/PTEN axis; thus, this study presents a novel therapeutic strategy or sepsis-associated AKI.

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“…11 LncRNA HCP5 regulates gemcitabine resistance for pancreatic cancer cells via sponging miR-214-3p and modulating HDGF. 12 Accumulating evidence suggest that Wnt/β-catenin pathway is a common oncogenic pathway in a volume of cancers. For instance, miR-133a-3p-mediated glycogen phosphorylase B contributes to ovarian cancer progression through activation of Wnt/β-catenin signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway

Bai¹,

Zhang

Fang

et al. 2020

Molecular Carcinogenesis

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Gastrointestinal stromal tumor (GIST) is a common mesenchymal tumor in the gastrointestinal tract. Prostate cancer associated transcript 6 (PCAT6) is a long noncoding RNA (lncRNA) and plays a pivotal role in tumor formation. Present study was designed to explore the function of PCAT6 in GIST. Ki67 staining, colony formation and trypan blue staining assays revealed that PCAT6 boosted GIST cell proliferation but inhibited cell apoptosis. Also, sphere formation assay and Western blot uncovered the promoting role of PCAT6 in GIST stemness. Then, we identified that PCAT6 could activate Wnt/β-catenin pathway. And the tumor facilitator role of Wnt/β-catenin pathway was validated in the rescue assays. Next, miR-143-3p was identified as the downstream microRNA of PCAT6. Moreover, miR-143-3p itself served as a tumor suppressor in GIST. Subsequently, peroxiredoxin 5 (PRDX5) was verified as the target of miR-143-3p. PCAT6 promoted GIST cell proliferation and stemness via sponging miR-143-3p to upregulate PRDX5. In a word, PCAT6 promoted GIST cell proliferation and stemness but inhibited cell apoptosis via competing endogenous RNA pattern and activation of Wnt pathway, which might contribute to GIST treatment. K E Y W O R D S ceRNA, gastrointestinal stromal tumor, PCAT6, PRDX5, Wnt/β-catenin

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<p>Long Noncoding RNA HCP5 Regulates Pancreatic Cancer Gemcitabine (GEM) Resistance By Sponging Hsa-miR-214-3p To Target HDGF</p>

Cited by 56 publications

References 27 publications

Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

Long Noncoding RNA TCONS_00016406 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating the miR-687/PTEN Pathway

PCAT6 mediates cellular biological functions in gastrointestinal stromal tumor via upregulation of PRDX5 and activation of Wnt pathway

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