&lt;p&gt;Long Non-Coding RNA BCAR4 Binds to miR-644a and Targets TLX1 to Promote the Progression of Bladder Cancer&lt;/p&gt;

Wang, Xiaojing; He, Hongchao; Wu, Rui; Xie, Xin; Wang, Dawei; Zhu, Yu

doi:10.2147/ott.s232965

Cited by 14 publications

(13 citation statements)

References 37 publications

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“…For example, the abnormal function of the lncRNAs BCAR4 affects the progression and metastasis of bladder cancer (X. Wang, He, et al, 2020). LINC-PINT is found as downregulated in the bladder cancer tissues and cells where it targets miR-155-5p and inhibits their proliferation, invasion, and migration ability (Table 1; Han et al, 2021).…”

Section: Bladder Cancermentioning

confidence: 99%

PINTology: A short history of the lncRNA LINC‐PINT in different diseases

et al. 2022

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LINC-PINT is a p53-induced long intergenic noncoding transcript that plays a crucial role in many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in total 102 (LNCipedia) alternatively spliced variants (LINC-PINT:1 to LINC-PINT:102). The functions of known variants include RNA transcripts, host transcripts for circular RNA (circRNA) generation and as sources for the translation of short peptides. In most human tumors, LINC-PINT is down-regulated where it serves as a tumor suppressor. However, the diversity of its functions in other maladies signifies its general clinical importance. Current LINC-PINT molecular functions include RNA-protein interactions, miRNA sponging and epigenetic modulation with these mechanisms operating in different cellular contexts to exert effects on biological processes ranging from DNA damage responses, cell cycle and growth arrest, senescence, cell migration and invasion, and apoptosis. Genetic polymorphisms in LINC-PINT have also been functionally associated with cancer and other pathologies including the autoimmune diseases pemphigus foliaceus and arthritis. Hence, LINC-PINT shows great potential as a clinical biomarker, especially for the diagnosis and prognosis of cancer. In this review, we explore the current knowledge highlighting the distinctive molecular functions of LINC-PINT in specific cancers and other disease states.Ihtisham Bukhari and Muhammad Riaz Khan contributed equally to this study.

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Section: Bladder Cancermentioning

confidence: 99%

PINTology: A short history of the lncRNA LINC‐PINT in different diseases

et al. 2022

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“…The ceRNA hypothesis suggests that several lncRNAs are upregulated and promote BCa progression. BCAR4 promotes the proliferation, and tumor progression of BCa cells by decreasing miR-370-3p level, and sponging miR-644a to modulate the expression of TLX1 [ 31 , 32 ]. TMPO-AS1 contributes to proliferation by interacting with its sense mRNA TMPO or sponging miR-98-5p and upregulating EBF1 [ 33 , 34 ].…”

Section: Cell Proliferationmentioning

confidence: 99%

“…The expression level of 4 lncRNAs positively correlates with tumor progression stage and TNM stage [ 59 , 88 , 184 , 194 ]. The expression of SNHG16 [ 83 ], BCAR4 [ 32 ], and SLCO4A1-AS1 [ 45 ] is related to metastasis and pathological stage. In addition, the high expression levels of LINC01296 [ 155 ], Carlo-7 [ 75 ], and ROR1-AS1 [ 54 ] are correlated with advanced tumor stage, higher tumor grade, and metastasis.…”

Section: Lncrnas Are Associated With Clinicopathological Characteristicsmentioning

confidence: 99%

“…In addition, lower expression of 7 lncRNAs predicted shorter OS [ 24 , 26 , 57 , 126 , 150 , 152 , 186 ]. High expression of 28 lncRNAs predicted shorter OS [ 23 , 27 , 32 , 39 , 40 , 45 , 50 , 53 , 60 , 83 , 94 , 100 , 118 , 121 , 123 , 128 , 130 , 137 , 141 , 146 , 155 , 156 , 162 , 164 , 185 , 192 , 194 , 197 ].…”

Section: Lncrnas That Influence Patient Prognosismentioning

confidence: 99%

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Biological functions and clinical significance of long noncoding RNAs in bladder cancer

et al. 2021

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Bladder cancer (BCa) is one of the 10 most common cancers with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNAs), a large class of noncoding RNA transcripts, consist of more than 200 nucleotides and play a significant role in the regulation of molecular interactions and cellular pathways during the occurrence and development of various cancers. In recent years, with the rapid advancement of high-throughput gene sequencing technology, several differentially expressed lncRNAs have been discovered in BCa, and their functions have been proven to have an impact on BCa development, such as cell growth and proliferation, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, and drug-resistance. Furthermore, evidence suggests that lncRNAs are significantly associated with BCa patients’ clinicopathological characteristics, especially tumor grade, TNM stage, and clinical progression stage. In addition, lncRNAs have the potential to more accurately predict BCa patient prognosis, suggesting their potential as diagnostic and prognostic biomarkers for BCa patients in the future. In this review, we briefly summarize and discuss recent research progress on BCa-associated lncRNAs, while focusing on their biological functions and mechanisms, clinical significance, and targeted therapy in BCa oncogenesis and malignant progression.

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“… 14 , 15 Among them, mutations of specific lncRNAs may promote the formation, progression and metastasis of tumors in many human malignancies including BC. 16 , 17 Based on these characteristics, we believe that lncRNA plays an important role in the occurrence, development, treatment, and prognosis of tumors. However, the function of most lncRNAs remains unclear.…”

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confidence: 99%

LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p

Han¹,

Liu²,

Liu³

et al. 2021

CMAR

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Background This study mainly explored the expression level of LINC-PINT in bladder cancer and its relationship with prognosis. Meanwhile, the effect of LINC-PINT on the biological function of bladder cancer was also explored. Methods The expression levels of LINC-PINT and miR-155-5p were detected by qRT-PCR. The prognostic significance of LINC-PINT in bladder cancer was studied by the Kaplan–Meier curve and Log rank test. CCK-8 and Transwell assays were used to analyze the proliferation, migration, and invasion ability. The targeting relationship between LINC-PINT and miR-155-5p was analyzed using bioinformatics and dual-luciferase reporter assays. Results The expression of LINC-PINT was downregulated in bladder cancer tissues and cell lines, and miR-155-5p showed the opposite trend in bladder cancer tissues. Kaplan–Meier curve proved that the patients with low LINC-PINT expression had a lower five-year survival rate and the Log rank test displayed that LINC-PINT was a prognostic factor of BC. CCK-8 and Transwell results showed that LINC-PINT could inhibit the ability of proliferation, migration, and invasion. LINC-PINT was proved to target miR-155-5p in bladder cancer. Dual-luciferase reporter gene assay showed that the relative luciferase activity of overexpression miR-155-5p co-transfected with LINC-PINT-wt was significantly lower. LINC-PINT was negatively correlated with miR-155-5p. Conclusion LINC-PINT is a potential prognostic marker of bladder cancer, and the up-regulation of Lin-PINT can inhibit the proliferation, invasion, and migration of bladder cancer cells by targeting miR-155-5p.

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<p>Long Non-Coding RNA BCAR4 Binds to miR-644a and Targets TLX1 to Promote the Progression of Bladder Cancer</p>

Cited by 14 publications

References 37 publications

PINTology: A short history of the lncRNA LINC‐PINT in different diseases

PINTology: A short history of the lncRNA LINC‐PINT in different diseases

Biological functions and clinical significance of long noncoding RNAs in bladder cancer

LINC-PINT Inhibited Malignant Progression of Bladder Cancer by Targeting miR-155-5p

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