&lt;p&gt;Local ozone (O&lt;sub&gt;2&lt;/sub&gt;–O&lt;sub&gt;3&lt;/sub&gt;) versus corticosteroid injection efficacy in plantar fasciitis treatment: a double-blinded RCT&lt;/p&gt;

Bahrami, Mohammad Hasan; Raeissadat, Seyed Ahmad; Barchinejad, Mahboobeh; Elyaspour, Dariush; Rahimi‐Dehgolan, Shahram

doi:10.2147/jpr.s202045

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…4 Nonsurgical treatment options include rest, ice application, stretching, exercise, proper footwear, arch supports, orthotics, night splints, extracorporeal shockwave therapy (ESWT), 5 anti-inflammatory agents, and various injections including corticosteroid (CS), platelet-rich plasma (PRP), 6,7 prolotherapy, 8 autologous whole blood, 9 botulinum toxin 10 or ozone. 11 CSs are the most common injection modality for PF. Based on a Cochrane review, CS injections have temporary effects for near 24 weeks.…”

Section: Introductionmentioning

confidence: 99%

<p>Ultrasound-Guided Injection of High Molecular Weight Hyaluronic Acid versus Corticosteroid in Management of Plantar Fasciitis: A 24-Week Randomized Clinical Trial</p>

Raeissadat¹,

Nouri²,

Darvish³

et al. 2020

JPR

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Background and Aims: Plantar fasciitis (PF) is the leading cause of heel pain in adults. This study was designed to evaluate the effect of hyaluronic acid (HA) injection in reducing the symptoms of PF, compared with corticosteroid (CS) injection as a conventional treatment. Methods: In this triple-blind, randomized, clinical trial, 75 patients who had the symptoms of PF for at least 3 months were randomly divided into two groups of 38 and 37 individuals. Then, each patient received either a single injection of high molecular weight (>2000 kDa) HA (1 mL HA 20 mg + 1 mL lidocaine 2%) or CS (1 mL methylprednisolone 40 mg + 1 mL lidocaine 2%) under the ultrasonography (US) guidance. Visual analog scale (VAS), foot ankle ability index (FAAI), pressure pain threshold (PPT), functional foot index (FFI), and plantar fascia thickness (PFT) were measured using US at baseline, 6 weeks and 24 weeks after the injection. Eventually, at the end of the treatment period, the patients' satisfaction was measured. Intention to treat analysis was used to assess the results. Results: After 24 weeks of follow-up, results from 60 subjects were fully obtained; however, results of 73 patients included into intention to treat analysis in the sixth-week followup. In both groups, VAS, PFT and FFI decreased, while FAAI and PPT increased significantly (P <0.001). At the baseline and at the 24th-week, no significant difference between the two groups was observed in any of the variables. However, a comparison between the baseline and the sixth-week results shows a prominent decrease in PPT and PFT in the CS group compared to the HA group (P = 0.004 and P = 0.011). Finally, there were no statistical differences between the two groups in treatment satisfaction (P = 0.618). Conclusion: Both CS and HA were effective modalities for PF and can improve pain and function with no superiority in 24th-week follow-ups, although CS seems to have a faster trend of improvement in the short term.

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Section: Introductionmentioning

confidence: 99%

<p>Ultrasound-Guided Injection of High Molecular Weight Hyaluronic Acid versus Corticosteroid in Management of Plantar Fasciitis: A 24-Week Randomized Clinical Trial</p>

Raeissadat¹,

Nouri²,

Darvish³

et al. 2020

JPR

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“…There was no difference between the two groups in terms of pain and functional level. 39 In another study, Babaei-Ghazani et al, 30 patients diagnosed with PF were divided into two groups, the first group being treated with a methylprednisolone injection and OT being applied to the second group, both then followed for three months. As a result, they found that both methods were effective in the treatment of PF that and there was no statistically significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effectiveness of platelet rich plasma and ozone therapy in plantar fasciitis treatment

Yalçın¹

2020

Int J Res Med Sci

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Background: Plantar fasciitis (PF) is one of the most common foot problems in adults. Conservative treatments are proportionally 90-95% successful. In this study, author aimed to compare the effectiveness of ozone therapy (OT) treatment of platelet rich plasma (PRP) injections in PF patients.Methods: In the study, which was made prospectively, patients were randomly divided into two groups. In the first group (n=20), patients were injected with PRP in 3 sessions at a one week intervals, and in the second group (n=22) OT was injected in the same way. Each patient was evaluated with visual pain score before as well as 1 month after treatment in terms of pain, whereas the foot function index (FFI) was evaluated with the score in terms of functionality.Results: In both groups, the 1st month VAS score and FFI score showed significant decrease (p<0.05) after treatment compared to before treatment. The decrease in VAS score and FFI score after treatment in the PRP group was significantly higher than the OT group (p˂0.05).Conclusions: As a result of this study, authors found that both PRP and OT were beneficial in terms of pain and functional level in the treatment of PF, but in patients who underwent PRP, authors found that there was more statistical improvement in terms of both parameters than patients who received OT. In light of the absence of a previous publication comparing these two treatment options in PF treatment, this study contributes to the literature.

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“…A linear array transducer (6-13 MHz) (Acuson Freestyle, Siemens, Germany) figure (1) was used to measure the plantar fascia thickness and injection of the study drugs. To minimize the pain during the intervention: a pre-procedure block of posterior tibial was done guided by the ultrasound using 2ml 1% lidocaine hydrochloride figure (3).…”

Section: Patient and Materialsmentioning

confidence: 99%

“…The definite pathogenesis still not clear, but many causes are there as prominent heel spurs, overuse, repetitive microtrauma which could cause such pain and pathology. 1 Plasma is the liquid part of the blood in which the blood cells and platelets are suspended; it is a watery component that contains the different proteins and electrolytes. 2 Platelet-rich plasma (PRP) is a high concentration of autologous platelets in a small volume of plasma produced by centrifugation of the patient's blood.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ultrasound-Guided Injection of Local Ozone or Platelet Rich Plasma Versus Corticosteroid in Plantar Fasciitis

Elsawy

Abdelraouf

2021

Al-Azhar International Medical Journal

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Background : Plantar fasciitis or recently called plantar fasciopathy, generally observed with heel spurs because of the deposition of calcium, although the definite pathology is still unknown. Ultrasound-guided injection of conventional corticosteroids was the primary treatment modality, with other emerging substances (e.g. Ozone or Platelet Rich Plasma PRP). Aim of the study: This study was conducted to evaluate the effect of ultrasound-guided injection of local Ozone or Platelet Rich Plasma (PRP) versus conventional corticosteroid in the management of plantar fasciitis. Patient and methods: this a randomized Prospective comparative study has done Al-Azhar university hospitals (Al-Hussein and Sayed Galal), where fifty-one patients have been diagnosed to have plantar fasciitis were included and allocated into one of three groups (17 patients in each group) to receive an ultrasound-guided injection of corticosteroid (control group), platelet-rich plasma (PRP) or Ozone O2-O3. Clinical evaluation and ultrasonographic measurement of the plantar fascia thickness was done before, at one, three and six months next to the injection. Primary outcome included: pain score using the visual analogue score (VAS). While secondary outcomes were plantar fascia thickness and foot quality health status. Results: There was a highly significant decrease in VAS score and plantar fascia thickness, and an increase in foot pain domain of the foot health status (FHSQ) score in corticosteroid and Ozone groups (p < 0.01 respectively) in one month. Regarding 3-month results, there was a highly significant decrease in VAS score plantar fascia thickness, and an increase in FHSQ score in the corticosteroid group (p < 0.01 respectively). Regarding long-term 6-month results, there was a highly significant decrease in VAS score, plantar fascia thickness, and an increase in FHSQ score in the PRP group (p < 0.01 respectively). Conclusion:Corticosteroid and Ozone injections were effective at shortterm assessment, but PRP was more valuable at long-term assessment regarding pain management in plantar fasciitis patients.

show abstract

<p>Local ozone (O<sub>2</sub>–O<sub>3</sub>) versus corticosteroid injection efficacy in plantar fasciitis treatment: a double-blinded RCT</p>

Cited by 9 publications

References 31 publications

<p>Ultrasound-Guided Injection of High Molecular Weight Hyaluronic Acid versus Corticosteroid in Management of Plantar Fasciitis: A 24-Week Randomized Clinical Trial</p>

<p>Ultrasound-Guided Injection of High Molecular Weight Hyaluronic Acid versus Corticosteroid in Management of Plantar Fasciitis: A 24-Week Randomized Clinical Trial</p>

Comparison of the effectiveness of platelet rich plasma and ozone therapy in plantar fasciitis treatment

Effect of Ultrasound-Guided Injection of Local Ozone or Platelet Rich Plasma Versus Corticosteroid in Plantar Fasciitis

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