&lt;p&gt;LncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein&lt;/p&gt;

Liu, Jianchao; Du, Wenfeng

doi:10.2147/ott.s195853

Cited by 28 publications

(22 citation statements)

References 22 publications

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“…Also, FENDRR was reported inhibiting various cancers such as colon cancer, hepatocellular carcinoma, etc. [13,19]. Similarly, FENDRR also had tumor suppressive property in CC, which was reflected by its downregulation in CC tissues and cells as well as the results of gain-of-function experiments.…”

Section: Discussionmentioning

confidence: 67%

“…However, biological effects and its mechanism with respect to CC remain to be explored. Mechanistically, FENDRR can exert tumor-inhibitory functions in colon cancer through repression of Sry-Related HMG-BOX-4 (SOX4) protein [13]. Moreover, FENDRR post-transcriptionally regulate Runt-related transcription factor 1 (RUNX1) by sponging miR-18a-5p [14].…”

Section: Introductionmentioning

confidence: 99%

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FENDRR suppresses cervical cancer proliferation and invasion by targeting miR-15a/b-5p and regulating TUBA1A expression

et al. 2020

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Background: Previous literature has revealed long non-coding RNAs (lncRNAs) are crucial regulators for cell functions and gene expression. LncRNA fetal-lethal non-coding developmental regulatory RNA (FENDRR) was reported as a biological suppressor in several types of human cancers, yet relevant mechanisms and biological effects of FENDRR with regards to cervical cancer (CC) are not explored until now. Methods: In this study, quantitative real-time polymerase chain reaction (qRT-PCR) analysis detected gene expression in tissues and cells. Gain-or loss-of-function experiments revealed the biological effects of FENDRR and miR-15a/b-5p on CC cell functions. Bioinformatics tools were used to predict the relevant genes. Mechanism experiments including RNA immunoprecipitation (RIP) assay, pull down assay and luciferase reporter assay depicted the binding situation and coexistence of indicated genes. Results: FENDRR was downregulated in CC tissues and cells, which suppressed CC progression. MiR-15a-5p and miR-15b-5p shared binding sites with FENDRR and had interaction with FENDRR. Tubulin alpha1A (TUBA1A) was downregulated in CC tissues and positively modulated by FENDRR. TUBA1A was the target of miR-15a/b-5p. TUBA1A silencing rescued the effect of FENDRR overexpression on CC cell growth and migration. Conclusion: FENDRR inhibits CC progression through upregulating TUBA1A in a miR-15a/b-5p-dependent manner.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

FENDRR suppresses cervical cancer proliferation and invasion by targeting miR-15a/b-5p and regulating TUBA1A expression

et al. 2020

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“…Long noncoding RNAs (lncRNAs), which are a recently discovered class of noncoding RNAs, are transcribed from noncoding sequences in the genome, are longer than 200 nt and do not have the ability to be translated into proteins (10,11). LncRNAs have become a novel research focus since numerous lncRNAs have been discovered that are closely related to the occurrence of a great number of diseases due to their extensive regulatory effects on epigenetics (12), transcription (13), and protein translation (14) and modification (15). Therefore, a systematic study of the regulatory role of lncRNAs in the pathogenesis of RA will help in more comprehensively understanding the mechanism of RA and providing new insight and targets for its clinical diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p

et al. 2021

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Rheumatoid arthritis (RA) is an autoimmune disease that occurs in approximately 1.0% of the general population. In RA patients, physical disability and joint damage are the major prognostic factors, which are associated with a reduction in the quality of life and early mortality. At present, the exact molecular mechanism of RA remains elusive. Long noncoding RNAs (lncRNAs) have been revealed to play a regulatory role in the pathogenesis of RA. To reveal the function of lncRNAs in rheumatoid arthritis, lncRNAS56464.1 was screened to verify its targeting of the microRNA (miR)-152-3p/Wnt pathway and its effect on the proliferation of fibroblast-like synoviocytes (FLS). In the present study, based on the competing endogenous RNA (ceRNA) theory, siRNA was designed for transfection into FLS to calculate the lncRNAS56464.1 interference efficiency and then the effect of lncRNAS56464.1 interference on FLS proliferation was detected by MTT assay. Then, lncRNAS56464.1 targeting of the miR-152-3p/Wnt pathway was detected by a dual-luciferase reporter assay. In addition, RT-qPcR, immunofluorescence and western blotting techniques were employed to detect the expression of lncRNAS56464.1, miR-152-3p and some key genes of the Wnt signaling pathway in FLS after lncRNAS56464.1 interference. The results revealed that lncRNAS56464.1 could combine with miR-152-3p and promoted the proliferation of FLS. In addition, lncRNAS56464.1 interference could not only decrease the proliferation of FLS and the expression of Wnt1, β-catenin, c-Myc, cyclin d1, and p-GSK-3β/GSK-3β, but it also increased the expression of SFRP4. The present data indicated that lncRNAS56464.1 could target the miR-152-3p/Wnt pathway to induce synovial cell proliferation and then participate in the pathogenesis of RA.

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“…A previous study found that the lncRNA HOTAIR promotes colon cancer development by downregulating miRNA-34a (Peng C. L. et al, 2019). The lncRNA FENDRR was found to inhibit colon cancer development by inhibiting the SOX4 protein (Liu and Du, 2019). In addition, a study found that the lncRNA CYTOR promotes metastasis in colon cancer through Wnt/βcatenin signaling (Yue et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identification of an Immune-Related Nine-lncRNA Signature Predictive of Overall Survival in Colon Cancer

et al. 2020

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Growing evidence suggests that immune-related genes (IRGs) and long non-coding RNAs (lncRNAs) can serve as prognostic markers of overall survival (OS) in patients with colon cancer. This study aimed to identify an immune-related lncRNA signature for the prospective assessment of prognosis in these patients. Gene expression and clinical data of colon cancer patients were downloaded from The Cancer Genome Atlas (TCGA). Immune-related lncRNAs were identified by a correlation analysis between IRGs and lncRNAs. In total, 447 samples were divided into a training cohort (224 samples) and a testing cohort (223 samples). Univariate, lasso and multivariate Cox regression analyses identified an immune-related nine-lncRNA signature closely related to OS in colon cancer patients in the training dataset. A risk score formula involving nine immunerelated lncRNAs was developed to evaluate the prognostic value of the lncRNA signature in the training dataset. Colon cancer patients with a high risk score had poorer OS than those with a low risk score. A multivariate Cox regression analysis confirmed that the immune-related nine-lncRNA signature could be an independent prognostic factor in colon cancer patients. The results were further confirmed in the testing cohort and the entire TCGA cohort. Furthermore, a gene set enrichment analysis revealed several pathways with significant enrichment in the high-and low-risk groups that may be helpful in formulating clinical strategies and understanding the underlying mechanisms. Finally, a quantitative real-time polymerase chain reaction assay found that the nine lncRNAs were significantly differentially expressed in colon cancer cell lines. The results of this study indicate that this signature has important clinical implications for improving predictive outcomes and guiding individualized treatment in colon cancer patients. These lncRNAs could be potential biomarkers affecting the prognosis of colon cancer.

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<p>LncRNA FENDRR attenuates colon cancer progression by repression of SOX4 protein</p>

Cited by 28 publications

References 22 publications

FENDRR suppresses cervical cancer proliferation and invasion by targeting miR-15a/b-5p and regulating TUBA1A expression

FENDRR suppresses cervical cancer proliferation and invasion by targeting miR-15a/b-5p and regulating TUBA1A expression

lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast‑like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR‑152‑3p

Identification of an Immune-Related Nine-lncRNA Signature Predictive of Overall Survival in Colon Cancer

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