<p>Lipid&ndash;polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives</p>

Abstract

Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. This review will provide an update on recent key advancements in design, synthesis, and bioactivity evaluation as well as discussion of future clinical possibilities of LPHNPs.

Development of Lipomer Nanoparticles for the Enhancement of Drug Release, Anti-Microbial Activity and Bioavailability of Delafloxacin

“…Polymeric nanoparticles are synthesized by using synthetic (e.g., PLGA) and natural (e.g., chitosan) polymers. The use of organic solvents during the synthesis of polymeric nanoparticles limits their application [17][18][19]. The limitations of both liposomes and polymeric nanoparticles can be overcome by the synthesis of lipid polymer hybrid nanoparticles (L-P-NPs), which possess both lipid and polymeric carriers.…”

Nanomedicine: Insights from a Bibliometrics-Based Analysis of Emerging Publishing and Research Trends

“…Articles focused on topics like nanoparticles, tumor biomarkers, and drug delivery. Szebeni [22] reviewed the literature on nano-psychiatry, finding that targeted pharmacotherapy enabled by nanocarriers (such as liposomes, micelles, polymer-conjugates, polymerosomes, dendrimers, aptamers and carbon nanotubes) represented the hottest research topic in the field, whereas lipid-polymer hybrid nanoparticles, next-generation core-shell nanostructures, as well as other bio-inspired nanoparticles appear to be promising nano-carriers in the field of nano-oncology [23,24], especially for cancers that are difficult to treat, like lung cancer [25].…”

Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery

“…The core and shell morphology might be obtained and the various hybrid nanoparticles were obtained by using the sonication [19], solvent emulsification, solvent evaporation [13], nanoprecipitation [20], extrusion, high speed homogenizers and other techniques. However, the selection of the method is based on the physicochemical properties of the loaded drug, size of the core particle and the desired properties that you want to introduce in the NP formulation [18]. For example, the single-step method has been chosen when the encapsulating materials are miscible with the coating substance and soluble in the organic solvent [21].…”

“…However, in the single-step method, the most investigated and revealed mechanism is the precipitation of the lipid component on the polymeric core material. Some newer techniques might also involve the self-assembling of these structural components (Figure 1) [18].…”