&lt;p&gt;Level of Adherence and Associated Factors Among HIV-Infected Patients on Antiretroviral Therapy in Northern Ethiopia: Retrospective Analysis&lt;/p&gt;

Desta, Abraham Aregay; Kidane, Kibriti Mehari; Woldegebriel, Ataklti Gebretsadik; Ajemu, Kiros Fenta; Berhe, Asfawosen Aregay; Zgita, Degnesh Negash; Teweldemedhn, Letebrhan Weldemhret; Woldegebriel, Lemlem Legesse; Bezabih, Nega Mamo; Woldearegay, Tewolde Wubayehu

doi:10.2147/ppa.s268395

Cited by 11 publications

(13 citation statements)

References 29 publications

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“…Although it has been documented that the best response to ART is seen when adherence is 100% [ 16 ], however, with the advent of new drugs such as the integrase strand transfer inhibitors and newer protease inhibitors, adherence with these drugs do not necessarily need to be 100% as the drugs could provide undetectable viral loads even with lower levels of adherence [ 38 – 40 ]. Nevertheless, the efficacy and durability of ART drug regimens still requires near perfect adherence rates as high as 95% or more [ 41 – 43 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with HIV treatment non-adherence among people living with HIV in three regions of Cameroon: A cross-sectional study

et al. 2023

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Background In Cameroon, HIV care decentralization is enforced as a national policy, but follow-up of people living with HIV (PLWH) is provider-driven, with little patient education and limited patient participation in clinical surveillance. These types of services can result in low antiretroviral therapy (ART) adherence. The objective of this study was to assess the prevalence and predictors of ART non-adherence among PLWH in Cameroon. Methods A cross-sectional descriptive study of PLWH in HIV treatment centres in Cameroon was conducted. Only PLWH, receiving treatment in a treatment centre within the country, who had been on treatment for at least six months and who were at least 21 years old were included in the study. Individuals were interviewed about their demographics and ART experiences. Data were collected using a structured interviewer-administered questionnaire and analyzed using STATA version 14. Results A total of 451 participants participated in this study, 33.48% were from the country’s Southwest region. Their mean age was 43.42 years (SD: 10.42), majority (68.89%) were females. Overall proportion of ART non-adherence among participants was 37.78%, 35.88% missed taking ART twice in the last month. Reasons for missing ART include forgetfulness, business and traveling without drugs. Over half of participants (54.67%) know ART is life-long, 53.88% have missed ART service appointments, 7.32% disbelieve in ART benefits, 28.60% think taking ART gives unwanted HIV Status reminder and 2.00% experienced discrimination seeking ART services. In the multivariate analysis, odds of ART non-adherence in participants aged 41 and above was 0.35 times (95%CI: 0.14, 0.85) that in participants aged 21–30 years, odds of ART non-adherence comparing participants who attained only primary education to those who attained higher than secondary education was 0.57 times (95%CI: 0.33, 0.97) and the odds of ART non-adherence in participants who are nonalcohol consumers was 0.62 times (95%CI: 0.39, 0.98) that in alcohol consumers. Conclusion High proportion of participants are ART non-adherent, and the factors significantly associated with ART non-adherence include age, education and alcohol consumption. However, some reasons for missing ART are masked in participants’ limited knowledge in taking ART, disbelief in ART benefits, feelings that ART gives unwanted HIV status reminder and experiencing discrimination when seeking ART services. These underscores need to improve staff (health personnel) attitudes, staff-patient-communication, and proper ART prior initiation counselling of patients. Future studies need to focus on assessing long-term ART non-adherence trends and predictors using larger samples in many treatment centres and regions.

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Section: Discussionmentioning

confidence: 99%

Prevalence and factors associated with HIV treatment non-adherence among people living with HIV in three regions of Cameroon: A cross-sectional study

et al. 2023

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“…Based on this study, baseline HIV stage is statistically associated significantly with adherence to ART in which patients with baseline HIV stage I was more likely to be adherent (AOR: 2.194 95% CI: 1.116, 4.314) as compared with patients with baseline HIV stage IV. This is similar to a retrospective study done in northern Ethiopia in which those patients with HIV stage II(AHR: 0.47 95% CI: 0.36, 0.60), WHO stage III (AHR: 0.25 95% CI: 0.19, 0.34), and WHO stage IV (AHR: 0.57 95% CI: 0.41, 0.81) had a lower risk to be adherent to the prescribed HIV medicine as compared with HIV stage I [ 13 ]. This may be due to the effect of serious opportunistic infections developed in the advanced stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

Determinant factors for adherence to antiretroviral therapy among adult HIV patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia: a case–control study

Abdu

Walelgn

2021

AIDS Res Ther

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Introduction World health organization defined adherence as the extent to which a person’s behavior – taking medications, following a diet, or executing lifestyle changes correspond with agreed recommendations from the health care provider. There is a contradiction among studies and previous studies conducted in the study area used a cross-sectional study design. This study aimed to identify determinant factors for adherence to antiretroviral treatment among people living with HIV at Dessie Referral Hospital by using an unmatched case–control study design. Methods and materials an institution-based unmatched case–control study design was used on a total sample of 582 (146 controls and 436 cases). Each respondent was selected by consecutive random sampling. The collected data were entered and analyzed by using Statistical Package for Social Science version 25.0. Multivariable binary logistic regression analysis was used to identify variables that were statistically significant determinants. Result The mean age of the respondents was 41.64 years. About 61.5% of the participants were females. Patients with baseline HIV stage I was more likely to be adherent to the prescribed HIV medicine (AOR: 2.194 95% CI: 1.116, 4.314) as compared with those with baseline WHO stage IV. Patients who did not take anti-tuberculosis medication collaterally with the prescribed HIV medicine were more likely to be adherent (AOR: 2.271 95% CI: 1.257, 4.102). Patients who took antiretroviral therapy for more than 24 months were more likely to be adherent (AOR: 3.665 95% CI: 1.321, 10.170). Conclusion Initiation of antiretroviral therapy at the later stage of the disease and taking anti-tuberculosis concomitantly were negatively associated with adherence. Being on antiretroviral therapy for a longer duration has a positive association. Health facilities and professionals should strictly apply strategies for the prevention of tuberculosis among HIV patients to avoid concomitant use of anti-tuberculosis medications.

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“…While risk factors as lower socioeconomic status, diagnosed in the earlier years are consistent with our study, female gender was not significant and age over 50 (compared than 40 - 49), was associated with MPR over 90% in our study. Regarding age and adherence, there have been discrepancies between studies and this may be associated with different target populations and categorization of age groups [ 24 ]. However, there were previous studies that reported reasons for poor adherence among young people as denial and fear of HIV infection, low self-esteem, and unstructured and chaotic lifestyles [ 25 26 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Human Immunodeficiency Virus Care Continuum in Korea using the National Health Insurance System Data

Cho

Chin

2021

Infect Chemother

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Background Antiretroviral therapy (ART) has been shown to significantly reduce the likelihood of transmission to other people as well as promoting the health of people living with Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) (PLH). The purpose of this study was to assess the HIV care continuum of PLH in Korea using the national health insurance system (NHIS) database. Materials and Methods From 2006 to 2015, ART prescription/laboratory test claim data and enlisted accompanying comorbidities were extracted from the NHIS database. Utilizing these data, proportion of PLH on ART among those who registered to Korea Disease Control and Prevention Agency (KDCA), HIV viral load testing, prescription trends of ART, medication possession ratio (MPR) of ART, and accompanying comorbidities were reviewed. Factors related with MPR <90% was also investigated among demographic factors, ART prescription, and accompanying comorbidities. Results During the observation period, the number of people receiving ART prescription increased from 2,076 in 2006 to 9,201 in 2015. Considering the number of PLHs reported by the KDCA, the proportion of PLHs who received ART prescription increased from 55.4% to 87.6% during the study period. The median value of ART MPR increased from 76.4% to 94.2% and the proportion of patients with MPR >90% increased from 54.3% to 78.2%. The most commonly accompanying comorbidities were dyslipidemia (55.7%), osteoporosis (16.3%), hypertension (15.7%) and diabetes (13.7%), respectively. The proportion of PLH with two or more comorbid conditions increased from 22.0% to 31.6%. Regarding the factors associated with suboptimal compliance, age less than 50 years old, under support of National Medical Aid, alcoholic liver disease, mental and behavioral disorders due to use of alcohol, and ART regimen of protease inhibitor and non-single table regimen integrase strand transfer inhibitor were related with MPR <90%. Conclusion The proportion of PLHs who received ART prescription and median MPR of ART increased during the study period. However, proportion of patients with MPR >90% was 78.2% in 2015 and there are still much room for improvement in the aspect of compliance.

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<p>Level of Adherence and Associated Factors Among HIV-Infected Patients on Antiretroviral Therapy in Northern Ethiopia: Retrospective Analysis</p>

Cited by 11 publications

References 29 publications

Prevalence and factors associated with HIV treatment non-adherence among people living with HIV in three regions of Cameroon: A cross-sectional study

Prevalence and factors associated with HIV treatment non-adherence among people living with HIV in three regions of Cameroon: A cross-sectional study

Determinant factors for adherence to antiretroviral therapy among adult HIV patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia: a case–control study

Assessment of Human Immunodeficiency Virus Care Continuum in Korea using the National Health Insurance System Data

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