<p>Irinotecan-Induced Skin Dryness Is Ameliorated By Orally Administered High-Dose Vitamin C In Mice</p>

Abstract

BackgroundVitamin C plays a part in various roles in the human body. In this study, we examined the effect of oral administration of high-dose vitamin C on the skin dryness induced by irinotecan.MethodsTo establish the experimental model of irinotecan-induced skin dryness, the drug was intraperitoneally administered for four consecutive days. Simultaneously, oral administration of high-dose vitamin C (4 g/kg) was continued for 4 days.ResultsHigh-dose vitamin C administration ameliorated the skin dryness induced by irinotecan. The expression of caspase-3 and caspase-9, reactive oxygen species, and the number of TUNEL-positive cells increased in the skin of irinotecan-treated mice but were lowered by high-dose vitamin C administration. In contrast, fibroblasts and collagen type I decreased in the skin of the irinotecan-treated mice but was increased by high-dose vitamin C administration.ConclusionThese results suggested that high-dose vitamin C administration can improve the skin dryness induced by irinotecan.

High-Dose Vitamin C Administration Inhibits the Invasion and Proliferation of Melanoma Cells in Mice Ovary

“…In our previous study, in a model of sodium dextran sulfate (DSS)-induced ulcerative colitis, administration of high-dose VC regulated neutrophil and cell apoptosis and improved ulcerative colitis. 23) In addition, irinotecan-induced skin dryness was improved by administering high-dose VC via ROS. 24) Furthermore, neutrophils and ROS were involved in azoxymethane + DSS-induced colorectal cancer.…”

“…23) In addition, irinotecan-induced skin dryness was improved by administering high-dose VC via ROS. 24) Furthermore, neutrophils and ROS were involved in azoxymethane + DSS-induced colorectal cancer. 19) In this study, neutrophils also play an important role in melanoma, suggesting that neutrophils are crucial in the pathological function of high-dose VC.…”

Irinotecan-Induced Serpentine Supravenous Hyper-Pigmentation

“…[ 3 ] Cutaneous adverse effects following irinotecan chemotherapy are rare and include alopecia, xerosis cutis, and localized acral hyper-pigmentation of skin, mucosa, and nails. [ 4 5 ]…”