<p>Intracranial Primary Malignant Solitary Fibrous Tumor/Hemangiopericytoma Masquerading as Meningioma: Report of a Rare Case</p>

Abstract

Background Intracranial solitary fibrous tumors/hemangiopericytomas (SFTs/HPCs) are rare spindle cell tumors originating from interstitial tissue that are usually benign. Primary malignant intracranial SFTs/HPCs are extremely rare. Here we describe a case of malignant intracranial SFT/HPC. Case Presentation A 59-year-old woman presented with a space-occupying lesion in the left cerebellar tentorium. Based on imaging findings, we made a preoperative diagnosis of meningioma. During the operation, we found that the tumor had an abnormally rich blood supply and could not be completely removed. Histologic findings, immunophenotype (positive for cluster of differentiation [CD]34, CD99, signal transducer and activator of transcription 6, and B cell lymphoma 2), and a Ki-67 proliferative index of 20–30% for the primary tumor were typical of malignant intracranial SFT/HPC. The tumors showed high sensitivity to radiotherapy and the residual tumor was significantly reduced after intensity-modulated radiation therapy. The patient has had no neurologic symptoms and no recurrence of the tumor in 2 years of follow-up. Conclusion Intracranial SFTs/HPCs are extremely rare. Radiologic examination before the operation is helpful for making a definite diagnosis and judging tumor grade; STAT6 immunohistochemistry is a sensitive alternative diagnostic method. Adjuvant radiotherapy is effective in cases of incomplete resection, and strict follow-up is essential in order to monitor for possible recurrence.

Intracranial Solitary Fibrous Tumor Mimicking Meningioma

“…Knowledge of these tumors is crucial for neurosurgeons to include them in the preoperative differential diagnosis Figure 1 O rbital compartment syndrome (OCS) is a rare but potentially serious complication that can occur after certain neurosurgical procedures, particularly those involving the skull base and the surrounding structures, which mainly due to flap compression from frontal or frontotemporal craniotomy. [1][2][3][4] It requires quick identification and immediate treatment for preservation of vision. 2 Herein, we present an even more unusual case of bilateral OCS following a frontal craniotomy with bicoronal flap.…”

“…[1][2][3][4] It requires quick identification and immediate treatment for preservation of vision. 2 Herein, we present an even more unusual case of bilateral OCS following a frontal craniotomy with bicoronal flap.…”

“…Only when the tumor grows large enough to compress or invade functional brain areas will patients exhibit corresponding clinical symptoms. These clinical symptoms include headaches, seizures, and sensory-motor disorders 2 …”

Clinicopathological Characteristics and Immunohistochemistry of Intracranial Hemangiopericytoma: Case Report and Literature Review

“…to SFT/HPC are 100% and 96.6%, respectively [21]. Karen et al [22] used 30 cases of tumors that were initially diagnosed as SFT/HPC meninges and found that all tumors expressed expression NAB2-STAT6 fusion, and it is believed that the fusion of NAB2 exon 4-STAT6 exon 3 is related to the classic SFT morphology and higher age, and shows a trend of decreased mitotic activity.…”