&lt;p&gt;Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis&lt;/p&gt;

Li, Na; Huang, Zhigang; Zhang, Yanda; Sun, Haitao; Wang, Jiamei; Zhao, Jian

doi:10.2147/cmar.s193658

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…A previous systematic review of myocardial infarction based on only three studies revealed that the incident cancer risk in the test group was nonsignificantly higher (OR = 1.08, 95% CI = [0.97–1.19]) than that in the control group. However, subgroup analysis revealed that the overall cancer risk was higher in women and during the first 6 months following myocardial infarction diagnosis ( Li et al, 2019 ). Further, our meta-analysis of eleven studies revealed a significantly higher incident cancer risk in patients with CAD with or without myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

“…According to a systematic review, increased cancer risk after myocardial infarction was only significant in women and patients with certain cancers such as lung cancer. However, some of the review’s analytic findings were based on only two or three studies and it only included patients with myocardial infarction, not all patients with CAD ( Li et al, 2019 ). Recently, a large cohort study demonstrated that atherosclerotic cardiovascular disease itself increased cancer incidence after a median follow-up of 1,020 days ( Suzuki et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

Chen

Pan

et al. 2023

PeerJ

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Objective Coronary artery disease (CAD) and cancer are the two leading causes of death worldwide. Evidence suggests the existence of shared mechanisms for these two diseases. We aimed to conduct a systematic review and meta-analysis to investigateassociation between CAD and incident cancer risk. Methods We searched Cochrane, PubMed, and Embase from inception until October 20, 2021, without language restrictions. Observational cohort studies were used to investigate the association between CAD and incident cancer risk. Using random-effects models, the odds ratio (OR) and 95% confidence interval (CI) were calculated. We utilized subgroup and sensitivity analyses to determine the potential sources of heterogeneity and explore the association between CAD and specific cancers. This study was conducted under a pre-established, registered protocol on PROSPERO (CRD42022302507). Results We initially examined 8,533 articles, and included 14 cohort studies in our review, 11 of which were eligible for meta-analysis. Patients with CAD had significantly higher odds of cancer risk than those without CAD (OR = 1.15, 95% CI = [1.08–1.22], I2 = 66%). Subgroup analysis revealed that the incident cancer risk was significantly higher in both sexes and patients with CAD with or without myocardial infarction. Sensitivity analysis revealed that the risk remained higher in patients with CAD even after >1 year of follow-up (OR = 1.23, 95% CI = [1.08–1.39], I2 = 76%). Regarding the specific outcome, the incident risk for colorectal and lung cancers was significantly higher (OR = 1.06, 95% CI = [1.03–1.10], I2 = 10%, and OR = 1.36, 95% CI = [1.15–1.60], I2 = 90%, respectively) and that for breast cancer was lower (OR = 0.86, 95% CI = [0.77–0.97], I2 = 57%) in patients with CAD than in those without CAD. Conclusion CAD may be associated with incident cancer risk, particularly for lung and colorectal cancers, in men and women as well as patients with or without myocardial infarction. Early detection of new-onset cancer and detailed cancer surveillance programs should be implemented in patients with CAD to reduce cancer-related morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

Chen

Pan

et al. 2023

PeerJ

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“…Covariates assessed for potential confounding and mediating effects were selected based on previous research and included sociodemographic factors (age, sex, ethnicity, education, marital status, and income), lifestyle factors (smoking status, alcohol consumption, sleep, physical activity, body mass index (BMI), fruit and vegetable consumption (servings/day), and health status (previous diagnosis of diabetes [ 35 ] or myocardial infarction [ 36 ]). In addition, cancer specific risk factors were evaluated.…”

Section: Methodsmentioning

confidence: 99%

Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study

et al. 2023

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Background Evidence on the association between mental health disorders and cancer risk is inconclusive, despite well-established associations between mental health disorders and lifestyle factors such as smoking. This study examines the relationships between depression, anxiety and cancer risk, and the potential mediating effects of lifestyle factors. Methods A study of 34,571 participants aged 40–69 years in the CARTaGENE cohort was conducted. Depression was defined by questionnaire (PHQ-9), antidepressant use, and a composite of questionnaire, antidepressant use, or lifetime self-reported physician diagnosis. Anxiety was defined by questionnaire (GAD-7). Co-morbid depression and anxiety was also assessed. Cox regression models were used to investigate associations between mental health and risk of prostate, lung, and all cancers combined. Mediating effects of lifestyle factors were assessed using Baron and Kenny mediation criteria. Results There were positive associations between mental health disorders, all cancers and lung cancer risk, however with the exception of anxiety and lung cancer in women (Hazard Ratio [HR] = 1.67, 95% CI: 1.01–2.76), associations were attenuated with adjustment for sociodemographics, health status and lifestyle factors. In the mediation analysis, smoking accounted for 27%, 18%, and 26%, of the total effect between depression (PHQ-9), anxiety, and co-morbidity and lung cancer, respectively in women. In men, smoking accounted for 17% of the total effect between depression (PHQ-9, antidepressant, or lifetime self-report of physician diagnosis) and all cancers. Conclusions Positive associations were observed between mental health disorders, all cancer and lung cancer risk, however most relationships were attenuated with adjustment for lifestyle factors. Smoking status mediated a significant proportion of the relationships between mental health disorders and cancer risk.

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“…In the second study, the authors attributed the slightly increased cancer risk to baseline comorbidities. Finally, a recent review and meta-analysis focusing on the association between myocardial infarction and cancer reported a 9.5% estimated cancer incidence after myocardial infarction, a value that attained statistical significance only in female patients, and that was substantially restricted to breast cancer (22).…”

Section: Cancer Development In Hf Patients: Points and Counterpoints mentioning

confidence: 99%

Development of Cancer in Patients With Heart Failure: How Systemic Inflammation Can Lay the Groundwork

Ausoni

Azzarello

2020

Front. Cardiovasc. Med.

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In the last decade, cardiologists and oncologists have provided clinical and experimental evidence that cancer, and not only chemotherapeutic agents, can cause detrimental effects on heart structure and function, a consequence that has serious clinical implications for patient management. In parallel, the intriguing idea that heart failure (HF) may be an oncogenic condition has also received growing attention. A number of epidemiological and clinical studies have reported that patients with HF have a higher risk of developing cancer. Chronic low-grade systemic inflammation has been proposed as a major pathophysiological process linking the failing heart to the multi-step process of carcinogenesis. According to this view, pro-inflammatory mediators secreted by the damaged heart generate a favorable milieu that promotes tumor development and accelerates malignant transformation. HF-associated inflammation synergizes with tumor-associated inflammation, so that over time it is no longer possible to distinguish the effects of one or the other. Experimental studies have just begun to search for the molecular effectors of this process, with the ultimate goal that of identifying mechanisms suitable for anti-cancer target therapy to reduce the risk of incident cancer in patients already affected by HF. In this review we critically discuss strengths and limitations of clinical and experimental studies that support a causal relationship between HF and cancer, and focus on HF-associated inflammation, cardiokines and their endocrine functions linking one and the other disease.

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<p>Increased cancer risk after myocardial infarction: fact or fiction? A systemic review and meta-analysis</p>

Cited by 11 publications

References 28 publications

Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

Association between coronary artery disease and incident cancer risk: a systematic review and meta-analysis of cohort studies

Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study

Development of Cancer in Patients With Heart Failure: How Systemic Inflammation Can Lay the Groundwork

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