<p>In vivo Antidiabetic Activity Evaluation of Aqueous and 80% Methanolic Extracts of Leaves of <em>Thymus schimperi</em> (Lamiaceae) in Alloxan-induced Diabetic Mice</p>

Abstract

Introduction Diabetes mellitus disorder characterized by increase in serum glucose level as a result of change in fat, protein metabolism, and carbohydrate. The aim of the present study was to investigate the effects of the aqueous and hydroalcoholic leaf extract of Thymus. schimperi on blood glucose levels. Methods The aqueous and 80% methanol extracts of T. schimperi leaves were prepared. Swiss albino mice of either sex weighing 20–30 g were selected for the experiments. Mice that were made diabetic were divided into seven groups to study the antihyperglycemic effect of the extracts. Diabetes was induced by single intraperitonial injection of alloxan monohydrate (180 mg/kg body weight). Results After diabetic mice were treated with an extract of solvent at doses of 250 and 500 mg/kg for 21 days, there were significant decreases in fasting blood glucose when compared to diabetic controls. The observed antidiabetic activity could be associated with the phytochemicals present in this plant extract. The extract of solvent also prevented body weight loss of diabetic when compared to diabetic mice group. It was also observed that the extracts have shown no acute toxicity at a dose of 2 g/kg. Conclusion The aqueous and 80% methanol extracts of T. schimperi leaves have shown blood glucose level lowering effects in diabetic mice. Hence, the present study might support the traditional use of T. schimperi for diabetes mellitus treatment.

The Potential of Lamiaceae Herbs for Mitigation of Overweight, Obesity, and Fatty Liver: Studies and Perspectives

“…Other Thymus species seem to have anti-diabetic potential: T. schimperi Ronniger seems to lower the blood GLU in alloxan-insulted diabetic mice [ 52 ], and T. praecox Opiz restores GLU homeostasis, ameliorates insulin resistance, and improves pancreatic β-cell function in streptozotocin/nicotinamide-induced diabetic rats [ 53 ].…”

Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials—Review of Perspectives for Novel Therapies

“…Recent studies have shown promising activity of extract of Thymus schimperi Ronniger in animal models of preeclampsia [ 108 ]. This species belongs to the Lamiaceae family, is a representative plant of Ethiopia [ 109 ], and contains mainly essential oil (i.e., β-myrcene, α-terpinene, limonene, α-humulene, p-cymene) [ 110 ]. Various extracts of T. schimperi have shown anti-oxidant potential [ 111 ], anti-hyperglycemic properties [ 109 ], and anti-hypertensive activity [ 112 ].…”

“…This species belongs to the Lamiaceae family, is a representative plant of Ethiopia [ 109 ], and contains mainly essential oil (i.e., β-myrcene, α-terpinene, limonene, α-humulene, p-cymene) [ 110 ]. Various extracts of T. schimperi have shown anti-oxidant potential [ 111 ], anti-hyperglycemic properties [ 109 ], and anti-hypertensive activity [ 112 ]. Mergiaw et al [ 108 ] firstly studied the effect of aqueous crude extract from leaves of T. schimperi at doses of 250, 500, and 1000 mg/kg/day administered to rats with preeclampsia induced by L-NAME (50 mg/kg, p.o.).…”

Efficacy, safety and phytochemistry of medicinal plants used for the management of diabetes mellitus in Ethiopia: a systematic review

“…Ten of the total studies were conducted in the southern nation nationalities region, 9 in Amhara, four in Tigra, 3 in Addis Abab, 3 in Oromia. Seven studies were done in Moringa Stenopetala [7-9, 11, 17, 19, 23], 2 in Aloe megalacantha B [14,25], 2 in Bersama abyssinica Fresen [32,34], 2 in Datura stramonium [12,31], 2 in Thymus schimperi [26,29], and 14 in different plants. Three in vitro studies were conducted on four plants (Terminalia brownie Fresen, Moringa Stenopetala, Aloe megalacantha B, and Aloe monticola R.) (Table 1).…”