&lt;p&gt;Impact of Thermal Pulsation Treatment on Astigmatism Management and Outcomes in Meibomian Gland Dysfunction Patients Undergoing Cataract Surgery&lt;/p&gt;

Matossian, Cynthia

doi:10.2147/opth.s263046

Cited by 16 publications

(19 citation statements)

References 17 publications

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“…Additionally, previous studies have demonstrated that the improvement in ocular surface irregularity increased the accuracy of measurement of corneal power and predicted postoperative refraction [7,11,24]. Our main findings, where P-SE significantly improved after dry eye treatment with rebamipide, may be supported by these reports.…”

Section: Discussionsupporting

confidence: 86%

The Effect of Rebamipide on Refractive Accuracy of Cataract Surgery in Patients with Dry Eye

2022

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Introduction: Refractive accuracy is crucial for increasing patient satisfaction after cataract surgery. Tear film instability caused by dry eye can lead to inaccurate measurement of corneal power, which is one of the most important factors for postoperative refractive calculation. This study investigated the effect of 2% rebamipide ophthalmic suspension on the predicted refractive accuracy for cataract surgery in patients with dry eye. Methods: This single-center, prospective, openlabel study included 35 dry eyes (with tear breakup time \ 5 s) who underwent cataract surgery. The patients were treated with rebamipide for 4 weeks before the preoperative examination. In addition to the usual evaluation of biometric variables essential for cataract surgery, tear breakup time (TBUT), superficial punctate keratopathy in the central part of the cornea (C-SPK), corneal higher-order aberrations (HOAs), and predicted postoperative spherical equivalent (P-SE) were evaluated at baseline and 4 weeks after dry eye treatment. The patients' subjective spherical equivalent (S-SE) was evaluated 1 month postoperatively. The difference between S-SE and P-SE was used to assess the accuracy of the P-SE. Improvement in TBUT, C-SPK, HOA, and the accuracy of P-SE after dry eye treatment were analyzed. Results: The accuracy of the biometry readings for the achieved P-SE was within 0.25 D in 42.9% and 54.3%; within 0.5 D in 71.4% and 88.6%; and within 0.75 D in 88.6% and 97.1% of eyes before and after rebamipide treatment, respectively (p \ 0.01). TBUT, C-SPK, and HOAs significantly improved after rebamipide treatment (p \ 0.01). Conclusion:Rebamipide significantly improved the corneal surface condition and accuracy of the predicted postoperative refraction in dry eyes.

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Section: Discussionsupporting

confidence: 86%

The Effect of Rebamipide on Refractive Accuracy of Cataract Surgery in Patients with Dry Eye

2022

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“…25,26 Because tear film instability of patients with dry eye can affect the repeatability of keratometry and biometry measurements, preoperative patients can benefit from MGD treatments that more rapidly stabilize the tear film to yield optimal ocular surface health and symptoms and more reliable presurgical plans. 27 Although 2-week efficacy results have been reported for Systane iLux treatment, 15 this is the first report of 1-week efficacy results. Similar to 1-month results, there were significant improvements in clinical signs and symptoms of MGD as soon as 1 week after treatment.…”

Section: Discussionmentioning

confidence: 86%

Efficacy of the Systane iLux Thermal Pulsation System for the Treatment of Meibomian Gland Dysfunction After 1 Week and 1 Month: A Prospective Study

Owen¹,

Klein²,

Yeh³

et al. 2021

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Objectives: To assess 1-week and 1-month efficacy of Systane iLux thermal pulsation treatment for meibomian gland dysfunction (MGD). Methods: This prospective, nonrandomized, open-label, multicenter study enrolled 30 adult patients (60 eyes) who had a Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire score greater than 6 and total meibomian gland secretion (MGS) score equal to or less than 12 in each eye. All participants received thermal pulsation treatment bilaterally. Primary efficacy measures included MGS score (sum of grades for 15 glands graded on a scale of 0-3; 0 [no secretion], 1 [inspissated], 2 [cloudy], and 3 [clear liquid]) and tear breakup time (TBUT). Secondary efficacy measures were SPEED and Ocular Surface Disease Index (OSDI) scores.Results: The mean age of patients was 52.9611.9 years. After 1 week, the mean MGS score improved significantly from 4.163.1 to 15.867.1 (right eye, OD) and 3.763.1 to 16.767.6 (left eye, OS); mean TBUT improved significantly from 4.964.1 to 8.463.6 (OD) and 5.264.2 to 8.963.9 (OS); and mean SPEED and OSDI scores improved significantly from 16.165.3 to 7.266.1 and 45.2621.3 to 19.0616.8, respectively (all P,0.001). After 1 month, the mean MGS score improved to 18.368.2 (OD) and 18.667.3 (OS); mean TBUT improved to 9.763.8 (OD) and 9.663.5 (OS); and mean SPEED and OSDI scores improved to 7.065.6 and 16.7614.5, respectively (all P,0.001). No adverse events were reported.Conclusions: Systane iLux thermal pulsation treatment for MGD resulted in a statistically significant increase in meibomian gland secretion, improvement in tear film stability, and reduction in dry eye symptoms as early as both 1 week and 1 month.

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“… 38 , 39 Failure to identify and treat dry eye and MGD prior to performing preoperative testing for cataract surgery negatively impacts visual outcomes. 40 It is also well known that the signs and symptoms of ocular surface disease (OSD) worsen after cataract surgery. 41 Demodex blepharitis is a lid margin disease that is known to increase MMP-9, a marker of inflammation, and negatively affect tear break-up time, 10 , 42 possibly affecting the ocular surface homeostasis and patient satisfaction following cataract surgery, particularly in patients undergoing premium intraocular lens (IOL) implantation.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Demodex Blepharitis in US Eye Care Clinic Patients as Determined by Collarettes: A Pathognomonic Sign

Trattler¹,

Karpecki²,

Rapoport³

et al. 2022

OPTH

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Purpose To evaluate the prevalence of Demodex blepharitis by its pathognomonic sign, collarettes, in patients presenting for any reason to eye care clinics in the United States. Patients and Methods In this retrospective study by 7 investigators at 6 eye care clinics, case records of consecutive patients who underwent a slit-lamp examination, regardless of chief complaint, were reviewed for Demodex blepharitis, as identified by the presence of collarettes. Patient characteristics, including age, gender, race, relevant ocular and systemic diagnoses, ocular medications, lid hygiene practices and contact lens wear, were also recorded. Results Of 1032 patients (mean age: 60.2 ± 17.8 years), 57.7% had Demodex blepharitis. While the prevalence of Demodex blepharitis in patients with dry eye disease (DED) (58.9%) and cataract (55.7%) was similar to the overall prevalence of Demodex blepharitis, it was higher in patients with blepharitis (69.1%) and glaucoma (64.8%). Among patients with collarettes, 44.0% had never been diagnosed with blepharitis. Among those on anti-inflammatory DED treatment, 60.0% had Demodex blepharitis. Demodex blepharitis prevalence was significantly higher among those using topical tea tree oil versus those who were not (74.5% versus 56.7% p = 0.014); prevalence was comparable among those using/not using lid wipes (56.9% versus 55.5%). Conclusion Demodex blepharitis, based on the pathognomonic finding of collarettes, is common and likely underdiagnosed among patients seeking eye care. These collarettes are still found in patients using over-the-counter treatments for blepharitis. The present study highlights the importance of screening patients for collarettes and Demodex blepharitis as part of every slit-lamp examination.

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<p>Impact of Thermal Pulsation Treatment on Astigmatism Management and Outcomes in Meibomian Gland Dysfunction Patients Undergoing Cataract Surgery</p>

Cited by 16 publications

References 17 publications

The Effect of Rebamipide on Refractive Accuracy of Cataract Surgery in Patients with Dry Eye

The Effect of Rebamipide on Refractive Accuracy of Cataract Surgery in Patients with Dry Eye

Efficacy of the Systane iLux Thermal Pulsation System for the Treatment of Meibomian Gland Dysfunction After 1 Week and 1 Month: A Prospective Study

The Prevalence of Demodex Blepharitis in US Eye Care Clinic Patients as Determined by Collarettes: A Pathognomonic Sign

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