&lt;p&gt;Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling&lt;/p&gt;

Ping, Mao-Hua

doi:10.2147/cmar.s270544

Cited by 13 publications

(5 citation statements)

References 26 publications

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“…Additionally, Hyperin—also known as quercetin-3-O-β- d -galactoside—is an important flavonoid constituent of okra. Hyperin has also been reported for its anticancerous potential in gastric cancer cells (CHI) by establishing an antiproliferative, antimigratory, and anti-invasive environment resulting in apoptosis by blocking the Wnt/β-catenin signal pathway [ 66 ].…”

Section: The Pharmacological and Potential Applications Of Okra-dementioning

confidence: 99%

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

et al. 2021

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Recently, there has been a paradigm shift from conventional therapies to relatively safer phytotherapies. This divergence is crucial for the management of various chronic diseases. Okra (Abelmoschus esculentus L.) is a popular vegetable crop with good nutritional significance, along with certain therapeutic values, which makes it a potential candidate in the use of a variety of nutraceuticals. Different parts of the okra fruit (mucilage, seed, and pods) contain certain important bioactive components, which confer its medicinal properties. The phytochemicals of okra have been studied for their potential therapeutic activities on various chronic diseases, such as type-2 diabetes, cardiovascular, and digestive diseases, as well as the antifatigue effect, liver detoxification, antibacterial, and chemo-preventive activities. Moreover, okra mucilage has been widely used in medicinal applications such as a plasma replacement or blood volume expanders. Overall, okra is considered to be an easily available, low-cost vegetable crop with various nutritional values and potential health benefits. Despite several reports about its therapeutic benefits and potential nutraceutical significance, there is a dearth of research on the pharmacokinetics and bioavailability of okra, which has hampered its widespread use in the nutraceutical industry. This review summarizes the available literature on the bioactive composition of okra and its potential nutraceutical significance. It will also provide a platform for further research on the pharmacokinetics and bioavailability of okra for its possible commercial production as a therapeutic agent against various chronic diseases.

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Section: The Pharmacological and Potential Applications Of Okra-dementioning

confidence: 99%

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

et al. 2021

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“…This is consistent with some early research results, which demonstrated that hyperin could promote the proliferation rate of mouse sperm cells [ 24 ] and promote the proliferation and differentiation of osteoblasts [ 25 ]. However, in some tumor diseases, hyperin inhibits the proliferation of tumor cells [ [26] , [27] , [28] , [29] ]. These contradictory results indicate that hyperin regulates proliferation in a cell-specific manner.…”

Section: Discussionmentioning

confidence: 99%

Hyperin promotes proliferation, migration, and invasion of HTR-8/SVneo trophoblast cells via activation of JAK1/STAT3 pathway in recurrent spontaneous abortions

Shen

Tang

et al. 2023

Heliyon

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“…The plausible mode of action was suggested to be via the inhibition of VEGF production leading to migration impairment, inducing apoptotic cell death [ 198 ]. Additionally, Abelmoschus -derived hyperin (quercetin-3-O-β-d-galactoside), an important flavonol glycoside phytocompound, was shown to induce strong anticancer potential against gastric cancer cells at a concentration of 50 and 100 µg/mL by targeting the Wnt/β-catenin signaling pathway which, in turn, inhibited cancer cell proliferation, migration, and invasion in both an in vitro and in vivo xenograft tumor mice model [ 199 ].…”

Section: Anticancer Effects and Cellular Targets Of Selected African ...mentioning

confidence: 99%

Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review

et al. 2023

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Africa is home to diverse medicinal plants that have been used for generations for the treatment of several different cancers and, presently, they are gaining interest from researchers as promising approaches to cancer treatment. This review aims to provide a comprehensive review of dietary and medicinal African fruits including their traditional uses, botanical description, ethnobotanical uses, bioactive phytochemical compositions, and anticancer properties investigated to date in vitro, in vivo, and in clinical studies. Data on recent updates concerning the traditional uses and anticancer properties of these fruits were collected from a myriad of available publications in electronic databases, such as Web of Science, PubMed, ScienceDirect, Scopus, SpringerLink, and Google Scholar. The results suggest that approximately 12 native or commercially grown African fruits belonging to different plant species, including Tribulus terrestris, Xanthium strumarium, Withania somnifera, Xylopia aethiopica, Abelmoschus esculentus, Carissa macrocarpa, Carpobrotus edulis, Syzygium cumini, Kigelia Africana, Annona muricata, Persea americana, and Punica granatum, have been reported for their potential as treatment options for the management of cancer. We further found that approximately eight different fruits from native plant species from Africa, namely, Sclerocarya birrea, Dovyalis caffra, Parinari curatellifolia, Mimusops caffra, Carpobrotus edulis, Vangueria infausta, Harpephyllum caffrum, and Carissa macrocarpa, have been widely used for the traditional treatment of different ailments but somehow failed to gain the interest of researchers for their use in anticancer research. In this review, we show the potential use of various fruits as anticancer agents, such as Tribulus terrestris, Xanthium strumarium, Withania somnifera, Xylopia aethiopica, Abelmoschus esculentus, Carissa macrocarpa, Carpobrotus edulis, Syzygium cumini, Kigelia Africana, Annona muricata, Persea americana, and Punica granatum; unfortunately, not enough reported research data have been published to gain thorough mechanistic insights and clinical applications. Additionally, we discuss the possibility of the utilization of potential phytochemicals from fruits like Persea americana and Punica granatum in anticancer research, as well as future directions.

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<p>Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling</p>

Cited by 13 publications

References 26 publications

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

Hyperin promotes proliferation, migration, and invasion of HTR-8/SVneo trophoblast cells via activation of JAK1/STAT3 pathway in recurrent spontaneous abortions

Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review

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