&lt;p&gt;Hyperconnectivity and High Temporal Variability of the Primary Somatosensory Cortex in Low-Back-Related Leg Pain: An fMRI Study of Static and Dynamic Functional Connectivity&lt;/p&gt;

Pei, Yixiu; Zhang, Yong; Zhu, Yanyan; Zhao, Yanlin; Zhou, Fuqing; Huang, Muhua; Wu, Lin; Gong, Honghan

doi:10.2147/jpr.s242807

Cited by 18 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And this mechanism seems to be universal as it holds for CRPS, chronic back pain, and osteoarthtitic pain ( 128 ). The default mode network, which controls self-representational processing has been suggested to become pathologically coupled to pain provoking networks in chronic pain ( 130 ). The relevance of this finding is enormous, since it could provide a neurobiological explanation for why in chronic pain becomes embodied, that is, becomes an integral part of the self, making treatments more difficult.…”

Section: Introductionmentioning

confidence: 99%

“…Based on network science principles it can be envisaged that each aspect of pain is the result of connectivity changes between the lateral pathway, i.e., somatosensory network, and another resting state network, such as the salience network (suffering), the default mode network (embodiment) and central executive network (cognitive disability) and motor network (physical disability) ( Figure 7 ). Patients with failed back surgery syndrome ( 147 ), migraine ( 148 ) and low back pain ( 130 ) are characterized by changes in the sensorimotor, salience, default mode and central executive networks. However, in these studies, no correlation analyses were performed to link these network changes to clinical syptoms or comorbidities, limiting the interpretation of what these changes mean.…”

Section: Introductionmentioning

confidence: 99%

“…In chronic pain this anti-correlation is lost ( 149 ). Indeed, chronic low back pain is characterized by hyperconnectivity of the primary somatosensory cortex to the default mode and executive control network ( 130 ). These somatotopic linkages between the somatosensory “painfulness” network and the “suffering” salience network, as well as the default mode, are limited to the homuncular cortical representation of the painful body area ( 127 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pain and the Triple Network Model

et al. 2022

View full text Add to dashboard Cite

Acute pain is a physiological response that causes an unpleasant sensory and emotional experience in the presence of actual or potential tissue injury. Anatomically and symptomatically, chronic pathological pain can be divided into three distinct but interconnected pathways, a lateral “painfulness” pathway, a medial “suffering” pathway and a descending pain inhibitory circuit. Pain (fullness) can exist without suffering and suffering can exist without pain (fullness). The triple network model is offering a generic unifying framework that may be used to understand a variety of neuropsychiatric illnesses. It claims that brain disorders are caused by aberrant interactions within and between three cardinal brain networks: the self-representational default mode network, the behavioral relevance encoding salience network and the goal oriented central executive network. A painful stimulus usually leads to a negative cognitive, emotional, and autonomic response, phenomenologically expressed as pain related suffering, processed by the medial pathway. This anatomically overlaps with the salience network, which encodes behavioral relevance of the painful stimuli and the central sympathetic control network. When pain lasts longer than the healing time and becomes chronic, the pain- associated somatosensory cortex activity may become functionally connected to the self-representational default mode network, i.e., it becomes an intrinsic part of the self-percept. This is most likely an evolutionary adaptation to save energy, by separating pain from sympathetic energy-consuming action. By interacting with the frontoparietal central executive network, this can eventually lead to functional impairment. In conclusion, the three well-known pain pathways can be combined into the triple network model explaining the whole range of pain related co-morbidities. This paves the path for the creation of new customized and personalized treatment methods.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pain and the Triple Network Model

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Resting-state dynamic FC (dFC) may be a useful neuroimaging method to overcome this static restriction and to explore time-varying patterns. More recent studies using the dFC method have proven high sensitivity in various neurological diseases, relative to the sFC analysis [ 12 , 13 ]. Notably, a previous dFC study showed distinctly more neuroimaging information between migraine and persistent posttraumatic headache patients than sFC analysis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura

et al. 2022

View full text Add to dashboard Cite

Background. Visual symptoms are common in patients with migraine, even in interictal periods. The purpose was to assess the association between dynamic functional connectivity (dFC) of the visual cortex and clinical characteristics in migraine without aura (MwoA) patients. Methods. We enrolled fifty-five MwoA patients as well as fifty gender- and age-matched healthy controls. Regional visual cortex alterations were investigated using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF). Then, significant regions were selected as seeds for conducting dFC between the visual cortex and the whole brain. Results. Relative to healthy controls, MwoA patients exhibited decreased ReHo and ALFF values in the right lingual gyrus (LG) and increased ALFF values in the prefrontal cortex. The right LG showed abnormal dFC within the visual cortex and with other core brain networks. Additionally, ReHo values for the right LG were correlated with duration of disease and ALFF values of the right inferior frontal gyrus and middle frontal gyrus were correlated with headache frequency and anxiety scores, respectively. Moreover, the abnormal dFC of the right LG with bilateral cuneus was positively correlated with anxiety scores. Conclusions. The dFC abnormalities of the visual cortex may be involved in pain integration with multinetworks and associated with anxiety disorder in episodic MwoA patients.

show abstract

“…Low back-related leg pain (LBLP) is a disease caused by intervertebral disc herniation and nerve root compression, which leads to low back pain or radiation pain of the lower extremities 1 and seriously affects patients’ work and daily lives 2 . Some studies have found that approximately one-quarter to one-third of LBLP patients still have pain after surgery 3 , which may be related to the changes in central plasticity in patients with chronic LBLP 4 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain

Pei

Peng

Zhang

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Neuroimaging studies have suggested a link between the intensity of chronic low back pain intensity and structural and functional brain alterations. However, chronic pain results from the coordination and dynamics among several brain networks that comprise the dynamic pain connectome. Here, we use resting-state functional magnetic resonance imaging and measures of static (sFC) and dynamic functional connectivity (dFC) variability in the typical (0.01–0.1 Hz) and five specific (slow-6 to slow-2) frequency bands to test hypotheses regarding disruption in this variability in low back-related leg pain (LBLP) patients who experience chronic pain and numbness. Twenty-four LBLP patients and 23 healthy controls completed clinical assessments, and partial correlational analyses between altered sFC and dFC variability and clinical measures were conducted. We found a lower within-network sFC in the ascending nociceptive pathway (Asc) and a lower cross-network sFC between nodes of the salience network and the Asc in the typical frequency band. In the slow-5 frequency band, a lower within-network sFC was found in the Asc. Abnormal cross-network sFC was found between nodes of the salience network-Asc (slow-5 and slow-6) and the default mode network-Asc (slow-4 and slow-6). Furthermore, cross-network abnormalities in the typical and certain specific frequency bands were linked to clinical assessments. These findings indicate that frequency-related within- and cross-network communication among the nodes in the dynamic pain connectome is dysfunctional in LBLP patients and that selecting specific frequencies may be potentially useful for detecting LBLP-related brain activity.

show abstract

<p>Hyperconnectivity and High Temporal Variability of the Primary Somatosensory Cortex in Low-Back-Related Leg Pain: An fMRI Study of Static and Dynamic Functional Connectivity</p>

Cited by 18 publications

References 48 publications

Pain and the Triple Network Model

Pain and the Triple Network Model

Disrupted Dynamic Functional Connectivity of the Visual Network in Episodic Patients with Migraine without Aura

Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain

Contact Info

Product

Resources

About