<p>Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer</p>

Abstract

Background: Oral route of administration is preferred for treating breast cancer, especially when continued disease management with good tolerability is required; however, orally administered chemotherapeutics combined with near-infrared (NIR) dyes are hindered by the low bioavailability, insufficient for the desired therapeutic efficacy. In this study, we developed a hybrid self-microemulsifying drug delivery system for co-loading curcumin–phospholipid complex and NIR dye IR780 (CUR/IR780@SMEDDS), to achieve combined phototherapeutic and chemotherapeutic effects against lung metastasis of breast cancer. Methods: CUR/IR780@SMEDDS were characterized. The efficacy against breast cancer metastasis was evaluated by photothermal and photodynamic assessment, cytotoxicity, invasion, and migration in metastatic 4T1 breast cancer cells in vitro, and in vivo oral bioavailability study in rats and pharmacodynamics studies in tumor-bearing nude mice. Results: CUR/IR780@SMEDDS improved oral bioavailability of curcumin and IR780 in rats compared with curcumin and IR780 suspensions. CUR/IR780@SMEDDS exhibited remarkable photothermal and photodynamic effects in vitro. In metastatic 4T1 breast cancer cells, CUR/IR780@SMEDDS combined with localized NIR laser irradiation induced significant cytotoxicity and inhibited invasion and migration of 4T1 cells, an outcome attributable to cumulative effects of IR780-induced hyperthermia and pharmacological effects of curcumin. In orthotopic 4T1 tumor-bearing nude mice, combination of oral administration of CUR/IR780@SMEDDS with local NIR laser irradiation inhibited tumor progression and suppressed lung metastasis.

Assessing the Combinatorial Chemo‐Photothermal Therapy Mediated by Sulfobetaine Methacrylate‐Functionalized Nanoparticles in 2D and 3D In Vitro Cancer Models

“…This deviation of the IR/SBMA-BSA NPs and IR+DOX/SBMA-BSA NPs absorptions toward the NIR zone has been attributed to changes in solvents' polarity and/or to different hydrophobic interactions occurring in the nanoparticles' core. [7,14,15,36] Considering that 808 nm light will be used in the photothermal experiments, the higher absorption of the nanoformulations at this wavelength may lead to a greater therapeutic outcome.…”

“…[10,11,12] To address this limitation, chemotherapeutic agents have been loaded into NIR-responsive nanomaterials. [11,[13][14][15] The temperature increase achieved upon NIR laser irradiation can trigger the release of the chemotherapeutic agents from the nanomaterials into the tumor zone, further contributing to an on-demand treatment. [8,16,17] In this way, the chemo-PTT mediated by nanomaterials can lead to an enhanced therapeutic effect when compared to the single therapies (nanomaterials' mediated PTT or chemotherapy).…”

<p>^99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation</p>

“…However, its clinical application has been limited because of its low solubility and rapid metabolism in vivo. [2][3][4][5][6][7][8][9] In the past decades, nanocarriers have been rapidly developed for drug delivery to increase solubility, prolong duration in vivo, improve tumor-selective cytotoxicity, and reduce drug exposure to normal tissues including polymeric nanoparticles, inorganic nanoparticles, and liposomes. [10][11][12][13][14][15][16][17][18] Polymeric nanocarriers may be composed of a synthetic polymer or natural polymer, both of which have exhibited good biocompatibility, an easily manipulated chemical structure, and stimuli-responsiveness.…”

Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines

“…A study by Xu et al [ 38 ] reported improved inhibitory effects of polyphenols on 4T1 cancer cells. Studies by Liu et al [ 39 , 40 , 41 ] have reported improved bioavailability of bioactive compounds, thus improving their potential inhibiting effect on breast cancer cells. The present study findings agree with the abovementioned reported studies, and those of other researchers such as Moeini [ 21 ] where phytosomes and other lipid phospholipid nanocarriers improved bioavailability of bioactive compounds, thus improving their efficacy in inhibiting breast cancer cells growth.…”