&lt;p&gt;Hsa_circ_0003645 Promotes Breast Cancer Progression by Regulating miR-139-3p/HMGB1 Axis&lt;/p&gt;

Zhang, Jinjun; Ke, Shun; Zheng, Weihong; Zhu, Zhi; Wu, Yanle

doi:10.2147/ott.s265796

Cited by 23 publications

(7 citation statements)

References 59 publications

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“…Mechanistically, cirCHIPK3 serves as a sponge for miR-193a, thereby reactivating HMGB1/PI3K/AKT signaling to promote proliferation, migration and invasion of breast cancer cells 69 . Another circRNA, Hsa_circ_0003645 have also been proved that can regulate miR-139-3p/HMGB1 axis to promote breast cancer progression 70 . However, there is a paucity of reports on how RNA sponges, or even competing endogenous RNA (ceRNA) regulatory networks, impact HMGB1-mediated breast cancer progression.…”

Section: The Biology Of Hmgb1mentioning

confidence: 99%

Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy

2022

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HMGB1 is a member of highly conserved high mobility group protein superfamily with intracellular and extracellular distribution. Abnormal HMGB1 levels are frequently manifested in various malignant diseases, including breast cancer. Numerous studies have revealed the clinical value of HMGB1 in the diagnosis and therapy of breast cancer. However, the dual function of pro- and anti-tumor makes HMGB1 in cancer progression requires more profound understanding. This review summarizes the functions and mechanisms of HMGB1 on regulating breast cancer, including autophagy, immunogenic cell death, and interaction with the tumor microenvironment. These functions determine the strategies for the development of chemotherapy, radiotherapy, immunotherapy and combination therapies by targeting HMGB1 in breast cancer. Defining the mechanisms of HMGB1 on regulating breast cancer development and progression will facilitate the application of HMGB1 as a therapeutic target for breast cancer.

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Section: The Biology Of Hmgb1mentioning

confidence: 99%

Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy

2022

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“…evidence confirmed that circRNAs serve as biomarkers in diverse clinical diseases, [8] including breast cancer. [9][10][11] For instance, hsa_-circ_0001785 [12] and hsa_circ_0003645 [13] were reported to act as biomarkers and participate in the advancement of breast cancer. A current study verified that hsa-circRNA-0088088 was considerably expressed in s both serum exosomes and tissues, which might function as competing endogenous RNAs (ceRNAs) and play a crucial role in the advancement of breast cancer.…”

mentioning

confidence: 99%

EIF4A3‐mediated hsa_circ_0088088 promotes the carcinogenesis of breast cancer by sponging miR‐135‐5p

Dong

2021

J Biochem & Molecular Tox

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Circular RNAs have participated in oncology progress. Nevertheless, the potential mechanisms are not completely understood. We intended to inspect the functions of hsa_circ_0088088 on breast malignancy, together with the possible mechanism(s). hsa_-circ_0088088 expression in breast malignancy was studied using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR). The overall survival was studied by the Kaplan-Meier curve. The biological functions of hsa_circ_0088088 aberrant expression on cell growth and metastasis were evaluated in MDA-MB-231 cells.Bioinformatics analysis, RNA immunoprecipitation (RIP), and qRT-PCR were accomplished to confirm the possible regulatory effects of eukaryotic initiation factor 4A3 (EIF4A3) on the biogenesis of hsa_circ_0088088. Furthermore, a dual-luciferase reporter assay, qRT-PCR, and RNA pull-down assay were used to confirm the association between the hsa_circ_0088088 and miR-135-5p in MDA-MB-231 cells. hsa_circ_0088088 was upregulated in the tumor tissues and cells, and higher expression presented an unfavorable prognosis. hsa_circ_0088088 overexpression promoted cell growth and metastasis in MDA-MB-231 cells. EIF4A3 was found to positively regulate hsa_circ_0088088. Furthermore, we confirmed that hsa_circ_0088088 sponges miR-135-5p and directly targets miR-135-5p with respect to the cell growth and metastasis in MDA-MB-231 cells. Our data suggest that EIF4A3-induced hsa_circ_0088088 stimulates the carcinogenic effects of breast tumors by sponging miR-135-5p.

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“…For example, the overexpression of circ-ABCB10 and circ_001783 were found to facilitate BC progression through sponging miR-1271 and miR-200c-3p respectively [26,27]. In addition, circ_0003645 was showed to promote BC proliferation by targeting miR-139-3p/HMGB1 signaling axis [28], and circ_0001667 could enhance BC cell survival by regulating TAZ in Hippo signal pathway [29]. In our study, we also demonstrated the upregulation of CircPRMT5 in BC tumors and cell lines, and the silencing of CircPRMT5 suppressed the aggressive phenotype of BC cells.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circPRMT5 is upregulated in breast cancer and is required for cell proliferation and migration

2021

Turk J Med Sci

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Objective. To evaluate the role of cyclic protein arginine methyltransferase 5 (circPRMT5) in the occurrence and development of breast cancer (BC). Methods. A total of 90 BC patients who underwent radical mastectomy and 40 age-matched healthy female controls were recruited in the Second People's Hospital of China Three Gorges University, Yichang Second People's Hospital from 2017 to 2020. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the expression levels of circPRMT5 in BC tissues, serum, normal breast cell line (MCF-10A) and BC cell line (T47D, MCF-7, BT549, Hs-578T and MDA-MB-231, MDA-MB-468). The associations between circPRMT5 expression level and age, tumor size, degree of differentiation, TNM stage, distant metastasis, estrogen receptor (ER) or progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status were analyzed. BC cell lines with circPRMT5 knockdown or overexpression were subject to CCK-8 cell proliferation assay, and transwell cell invasion/migration assay. Results. CircPRMT5 expression in BC tissue was higher than that in adjacent normal breast tissue. Consistently, the expression level of circPRMT5 was also elevated in serum samples collected from BC patients when compared with healthy controls. And in multiple breast cancer cell lines, circPRMT5 was upregulated as compared to normal breast epithelial MCF-10A cells. CircPRMT5 expression level was correlated with tumor size, TNM stage, lymph node metastasis distant metastasis, but no correlation was observed with ER, PR, HER2 status. Overexpression of circPRMT5 promoted the proliferation, invasion and migration of MCF7 cells; while the knockdown of circPRMT5 inhibited cell proliferation, invasion and migration. Conclusion.CircPRMT5 seems to act as an oncogene in the progression of BC. Our data suggest that CircPRMT5 may be used as a biomarker for the diagnosis, prognosis evaluation and targeted therapy of breast cancer.

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<p>Hsa_circ_0003645 Promotes Breast Cancer Progression by Regulating miR-139-3p/HMGB1 Axis</p>

Cited by 23 publications

References 59 publications

Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy

Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy

EIF4A3‐mediated hsa_circ_0088088 promotes the carcinogenesis of breast cancer by sponging miR‐135‐5p

Circular RNA circPRMT5 is upregulated in breast cancer and is required for cell proliferation and migration

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