<p>High Expression of miR-196b Predicts Poor Prognosis in Patients with Ovarian Cancer</p>

Abstract

Background/Aims: To analyze the clinical significance of miR-196b expression in ovarian cancer and predict the function and possible mechanism of miR-196b. Methods: Both Kaplan-Meier (K-M) and Cox proportional hazards regression model were used to analyze the prognostic factors of patients with ovarian cancer. MiR196-b was modulated in ovarian cancer cells, and the cell viability, cell cycle, and cell cycle-related gene expression were analyzed. The target genes of miR-196b were then predicted and checked the relationship between the target genes. Results: MiR-196b was an independent risk factor, while high expression of miR-196b was associated with poor prognosis of ovarian cancer. MiR-196b overexpression increased cancer cell proliferation. Cdkn1b, as one of the targets of miR-196b, was related to cell viability and mitosis. Conclusion: High expression of miR-196b was significantly associated with poor prognosis of the patients with ovarian cancer. MiR-196b could increase the cell proliferation of ovarian cancer by modulating Cdkn1b expression.

MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2)

“…According to the data obtained from the qRT-PCR experiment, miR-196b expression in the tumor tissue specimens of ESCC patients was increased. The expression of miR-196b in the four esophageal squamous cell carcinoma cell lines was also high, which was in keeping with previous studies where miR-196b was up-regulated in the non-small cell lung cancer, ovarian cancer, gastric cancer, breast cancer, and colon cancer [ 17 , 27–30 ]. However, there are differences in some cancers about the miR-196b expression.…”

“…In summary, miR-196b may have a prognostic value for ESCC. The prognostic value of high miR-196b expression was also observed in ovarian cancer [35], which confirmed the prognostic value of miR-196b in cancers.…”

“…Multiple aberrant expression genes were involved in the progression of ESCC, including miRNAs, such as miR-301a-3p and miR-25 [14][15][16]. miR-196b has unique tumor promotion/ inhibition effects in many types of cancers, such as ovarian cancer, lung cancer, and laryngeal cancer [17][18][19]. However, the impact of miR-196b in the progression of ESCC has not been studied.…”

Three-Dimensional Genome Organization in Breast and Gynecological Cancers: How Chromatin Folding Influences Tumorigenic Transcriptional Programs

“…Another example is the miR-196a expression landscape. This miRNA has been found to be overexpressed in ovarian and breast cancer [ 111 , 112 ]. miR-196b modulates cancer cell proliferation by inhibiting CDKN1B, promoting cancer cell migration and invasion [ 111 ].…”

“…This miRNA has been found to be overexpressed in ovarian and breast cancer [ 111 , 112 ]. miR-196b modulates cancer cell proliferation by inhibiting CDKN1B, promoting cancer cell migration and invasion [ 111 ]. Increased miR-196a expression has been linked to a loss of DNA methylation in the miRNA’s promoter regions, as well as long-range transcriptional regulation with the HOTAIR enhancer (HOTAIR distal enhancer, HDE) and a new miR-196a-Enhancer.…”