<p>Hepatitis B And Hepatitis C Viral Infections And Associated Factors Among Patients With Diabetes Visiting Gondar Referral Teaching Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study</p>

Abstract

BackgroundThe liver is the major site of Hepatitis B virus and Hepatitis C virus replications. Patients with diabetes tend to be at an increased risk for developing various forms of liver diseases. The infection of the liver can cause or exacerbate diabetes. On the other hand, diabetes can cause or intensify the severity of liver infection. This comparative cross-sectional study was conducted with the aim to determine the prevalence of Hepatitis B and Hepatitis C virus infections and associated factors among patients with diabetes visiting the University of Gondar referral teaching hospital, northwest Ethiopia.ResultsOut of the 610 participants (305 patients with diabetes, 305 people with no diabetes) of the study, 65 (10.7%) were positive for Hepatitis infections, of whom 44 (14.4%) and 21 (6.9%) were positive for at least one of the viruses in patients with diabetes and people with no diabetes, respectively. Out of the diabetic and non-diabetic groups of the study, 26 (8.5%) and 14 (4.6%) (95% CI, 0.96–4.02) were positive for Hepatitis B virus, respectively, while 23 (7.5%) and 7 (2.3%) (95% CI, 1.46–8.68) of the diabetes and non-diabetic groups were positive for Hepatitis C virus, respectively. History of blood transfusion (95% CI, 1.36–12.71) and unprotected sex (95% CI, 1.25–10.15) were significantly associated with Hepatitis B virus infection, while the type of diabetes (95% CI, 1.25–10.89) was associated with anti-Hepatitis C virus positivity.ConclusionPositivity for Hepatitis C virus was significantly associated with Type II diabetes. Blood transfusion and unprotected sex were risk factors for Hepatitis B virus infections. Further studies that elaborate temporal associations and find out explanations for the relationship between diabetes and Hepatitis C viral infections are of paramount importance.

Non-autoimmune diabetes mellitus and the risk of virus infections: a systematic review and meta-analysis of case-control and cohort studies

“…A total of 11 viruses were reported: HCV (43 studies) 10 , 24 – 60 , 82 , 84 , 86 , 88 , 89 , HBV (27 studies) 10 , 30 , 35 , 36 , 38 , 41 , 44 , 48 , 52 , 53 , 56 , 59 , 60 , 66 – 74 , 82 , 84 , 85 , HHV8 (8 studies) 12 , 61 – 65 , 81 , CMV (5 studies) 76 – 80 , SARS-CoV-2 (1 study) 83 , H1N1 virus (1 study) 87 , HSV1 (1 study) 75 , TTV (1 study) 37 , Parvovirus B19 (1 study) 79 , coxsackie B (1 study) 79 and HGV (1 study) 37 (Table 1 ).…”

Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies

“…A total of 20 (12,13,14,15,16,17,18,19,21,22,23,24,25,26,27,28,29,30,31,32) studies were analyzed with 245,468,411 subjects were enrolled this study which were published between 2003 to 2020. In which divided into two subgroups, 12,982,158 patients with HBV infected group and 232,486,253 patients in non infected HBV groups.…”

Seroprevalence of Hepatitis B and C Viruses and Their Associated Factors Among Military Personnel at Military Camps in Central Gondar, Ethiopia: A Cross-Sectional Study

“…14 Furthermore, the military is frequently mobile from place to place for different professional reasons and stays longer without their family, which may cause them to have multiple sex partners and increase their exposure to different sexually transmitted infections (STIs). 16 Several studies have reported the prevalence of HBV and HCV infections among different segments of the population in the study area [17][18][19][20][21][22][23][24] and there is a single report of armed forces in Bahir Dar, Amhara Regional State of Ethiopia. 16 No data were described the prevalence of viral hepatitis among military personnel in the study area.…”