<p>Growing teratoma syndrome with porta hepatis involvement &ndash; a case report</p>

Abstract

Growing teratoma syndrome is a rare entity of tumors, it arises seldomly from ovarian and testicular carcinoma. It presents with disseminating masses of mature teratoma during or following chemotherapy of malignant germ cell tumors. We are reporting a 19-year old presented with recurrent left ovarian mass and supra renal large mass close to the porta hepatis was seen on magnetic resonance imaging. This patient was treated 3 years ago for stage I immature teratoma with left ovarian cystectomy and chemotherapy. Surgical excision of the left ovary and the abdominal mass required meticulous dissection, and the mass was shaved off the porta hepatis with no intraoperative or postoperative complications. Pathology showed mature teratoma. She has no recurrent 5 years after treatment. To the best of our knowledge, this is the first case report describing close relation of growing teratoma syndrome to the porta hepatis, no such case report like this has been reported in our region.

Fertility preservation in growing Teratoma syndrome: Case report

“…Growing Teratoma Syndrome (GTS) was first described by Logothetis et al in 1982. This syndrome leads to the appearance of large masses of metastatic mature teratoma in diverse locations during or after chemotherapy in patients with immature germ cell tumors [7]. The diagnosis of GTS is based on three main criteria: personal history of germ cell tumor, radiological evidence of growing lesions during or after chemotherapy, and normal tumor markers [8]. Surgery is the primary treatment and the outcome depends on the size and location of GTS [9].…”

Somatic malignancy arising in growing teratoma syndrome – A case report

“…ones. 1 Development of GTS had been reported as early as 3 months and, in some cases, delayed till 12 years. Median time period is 26 months after chemotherapy.…”

“…Also are pelvis, lung, inguinal lymph node, forearm, mesentery, brain and liver. 1 The initial histopathology is usually immature teratoma grade 2 or 3. 3 A larger primary tumour (>10cm) also predispose to subsequent GTS.…”

“…This clinical entity was first described by Carr et al in 1981 in testicular teratocarcinoma and the term GTS was coined by Logothetis et al in 1982. 1 Incidence of GTS vary from 1.9 to 7.6% of teratoma cases. 1-2% teratomas can undergo malignant transformation, commonest of which is squamous cell carcinoma (80%).…”