&lt;p&gt;Glycosylated Hemoglobin A1c Is Associated with Anthropometric Measurements and Tumor Characteristics in Breast Cancer Patients&lt;/p&gt;

Ayoub, Nehad M.; Jaradat, Sara K.; Alhusban, Ahmed; Tahaineh, Linda

doi:10.2147/ijwh.s234408

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Apart from the associations with overall reduced physical health, significant associations were found for elevated plasma C-reactive protein and glycosylated hemoglobin HbA1c levels in breast cancer survivors [ 112 ]. Both have been previously identified as potential risk factors associated with cancer recurrence and comorbidities in breast cancer survivors [ 113 , 114 ]. Our own research concerning DAL in breast cancer survivors did not include disease-specific endpoints.…”

Section: Discussionmentioning

confidence: 99%

Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

Ronco

Storz

2023

Nutrients

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Dietary acid load (DAL) is recognized as a risk factor for several chronic disorders, including obesity, diabetes, and osteoporosis. Recent evidence suggests that an elevated DAL, as measured by the validated potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores, could also increase the risk for several cancers. This narrative review summarizes the potential role of DAL in Uruguayan cancer patients and outlines the potentially involved pathophysiological pathways that mediate the role of DAL in both cancer development and growth. Although Uruguay is a developing country, its average diet is a heavily meat-based Western one, translating into a supraphysiological acid burden from diet. In recent years, we have published epidemiologic evidence based on ten case-control studies involving 3736 cancer cases and 9534 hospital-based controls. Odds ratios and 95% confidence intervals were estimated for each interest variable to analyze the association between the exposure levels of DAL scores and cancer, calculated by unconditional logistic regression. In a majority of the cases, the highest DAL scores tended to double the cancer risk as compared to the lowest category. We also found high risks for methionine intake, an acidifying amino acid found in higher concentrations in animal-based foods, which may increase cancer risks at least by a joint action based on the pH and the proliferation enhancing properties of the amino acid itself.

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Section: Discussionmentioning

confidence: 99%

Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

Ronco

Storz

2023

Nutrients

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“…Breast cancer, the most frequent cancer in women, is a major public health issue. Several studies have provided strong evidence for a positive association between obesity, diabetes/IGT, and increased risk of breast cancer development as well as recurrent metastasis [30][31][32][33][34][35][36]. The combined effect of obesity and diabetes on breast cancer outcomes has been extensively reported in humans [21][22][23]37], and undiagnosed IGT is known to affect the survival of breast cancer patients [38].…”

Section: Discussionmentioning

confidence: 99%

Obesity Associated with Prediabetes Increases the Risk of Breast Cancer Development and Progression—A Study on an Obese Rat Model with Impaired Glucose Tolerance

Kallamadi,

Esari,

Addi

et al. 2023

IJMS

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Patients with comorbidities of obesity and diabetes are recognized to be at high risk of breast cancer development and face worse breast cancer outcomes. Though several reports showed the reinforced link between obesity, diabetes, and prediabetes with breast cancer, the underlying molecular mechanisms are still unknown. The present study aimed to investigate the underlying molecular link between increased risks of breast cancer due to coincident diabetes or obesity using a spontaneous obese rat model with impaired glucose tolerance (WNIN/GR-Ob rat). A single dose of solubilized DMBA suspension (40 mg/kg body weight) was orally administered to the animals at the age of 60 days to induce breast tumors. The tumor incidence, latency period, tumor frequency, and tumor volume were measured. Histology, immunohistochemistry, and immunoblotting were performed to evaluate the tumor morphology and expression levels of signal molecules. The development of mammary tumors in GR-Ob rats was characterized by early onset and shorter latency periods compared to control lean rats. While 62% of obese rats developed breast tumors, tumor development in lean rats was only 21%. Overexpression of ER, PR, Ki67, and p53 markers was observed in tumor tissues of obese rats in comparison with lean rats. The levels of the hallmarks of cell proliferation and angiogenesis involved in IGF-1/PI3K/Akt/GSK3β/β-catenin signaling pathway molecules were upregulated in obese rat breast tumors compared to lean rats. Furthermore, obesity with prediabetes is associated with changes in IGF-1 signaling and acts on PI3K/Akt/GSK3β/β-catenin signaling, which results in rapid cell proliferation and development of breast tumors in obese rats than the lean rats. These results indicate that tumor onset and development were faster in spontaneous obese rat models with impaired glucose tolerance than in their lean counterparts.

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“…Moreover, Wu et al also reported associations between DAL and elevated plasma CRP and HbA1c levels in breast cancer survivors [ 29 ]. Both are important risk factors associated with cancer recurrence and comorbidities in in this particular group [ 62 , 63 ]. A high DAL may contribute to systemic inflammation and hyperglycemia in cancer survivors [ 29 ], which, in turn, has been associated with a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Quantifying dietary acid load in U.S. cancer survivors: an exploratory study using NHANES data

Storz

Ronco

2022

BMC Nutr

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Background Diet is an important determinant of systemic pH and acid–base regulation. A frequent consumption of acid-inducing foods (including processed meats and cheese) combined with a low intake of base-inducing foods (such as fruits, legumes and vegetables) increases Dietary Acid Load (DAL), which has been associated with an increased risk for certain cancers. DAL also appears to be of paramount importance in cancer survivors, in whom it was associated with increased mortality and poor overall physical health. Literature on DAL in cancer survivors, however, is scarce and limited to a few studies. Methods Using cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES), we sought to quantify DAL in U.S. cancer survivors and contrasted the results to the general population. DAL was estimated using established formulas (Potential Renal Acid Load (PRAL) and Net Endogenous Acid Production (NEAP)). Results Our study comprised 19,413 participants, of which 1444 were self-reported cancer survivors. Almost 63% of cancer survivors were female (weighted proportion) with a mean age of 61.75 (0.51) years. DAL scores were consistently higher in cancer survivors (as compared to the general population) after adjustment for confounders in multivariate regression models. These differences, however, were not statistically significant (p = 0.506 for NEAPF, 0.768 for PRALR and 0.468 for NEAPR, respectively). Notably, DAL scores were positive throughout (> 0 mEq/d) in cancer survivors, suggesting an acidifying diet. Specific examples include mean PRALR scores > 11 mEq/d in cancer survivors aged 55 years and mean NEAPF scores > 50 mEq/d in cancer survivors aged 40–60 years). Conclusions The acidifying diet in this sample of cancer survivors warrants caution and requires further investigation. Comparably high DAL scores have been associated with adverse health outcomes and an increased mortality in previous studies in breast cancer survivors. Thus, increased awareness as well as additional clinical trials in this field are urgently warranted.

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<p>Glycosylated Hemoglobin A1c Is Associated with Anthropometric Measurements and Tumor Characteristics in Breast Cancer Patients</p>

Cited by 3 publications

References 51 publications

Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

Obesity Associated with Prediabetes Increases the Risk of Breast Cancer Development and Progression—A Study on an Obese Rat Model with Impaired Glucose Tolerance

Quantifying dietary acid load in U.S. cancer survivors: an exploratory study using NHANES data

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