&lt;p&gt;Gastrointestinal Problems in Chinese Children with Autism Spectrum Disorder&lt;/p&gt;

Lai, King Wai Chiu; Leung, Patrick; Hung, Se Fong; Shea, Caroline K S; Mo, Flora Y. M.; Che, Kiti K. I.; Tse, Chun‐Yu; Lau, Fanny L F; Ling, Suk; Wu, Justin Che Yuen; So, Suzanne Ho‐wai; Dadds, Mark R.

doi:10.2147/ndt.s260654

Cited by 5 publications

(8 citation statements)

References 47 publications

(71 reference statements)

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“…Functional gastrointestinal disorder (FGID) is common, with 1 in 5 children fulfilling criteria of at least 1 FGID in a community epidemiologic study (Saps et al, 2018). Functional gastrointestinal (GI) symptoms such as constipation and abdominal pain are prevalent in ASD (McElhanon et al, 2014), while the prevalence of FGID is higher in ASD than general population (Lai et al, 2020). It was also found that FGID in ASD is associated with immune anomalies and dysbiosis (Hsiao, 2014).…”

Section: Introductionmentioning

confidence: 99%

An elevated anxiety level among prepubertal autistic boys with non‐treatment‐seeking functional gastrointestinal disorders: A case–control study

et al. 2021

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Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11 years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. Lay summaryAnxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID.

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Section: Introductionmentioning

confidence: 99%

An elevated anxiety level among prepubertal autistic boys with non‐treatment‐seeking functional gastrointestinal disorders: A case–control study

et al. 2021

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“…It was reported that GI symptoms have been found to occur in 10% of TD children. 80 Children with ASD are 2.5 times more likely to suffer from GI symptoms than TD children. 80 The correlation coefficient between cases and their matched controls (phi) was 0.2.…”

Section: Methodsmentioning

confidence: 99%

“… 80 Children with ASD are 2.5 times more likely to suffer from GI symptoms than TD children. 80 The correlation coefficient between cases and their matched controls (phi) was 0.2. 81 At least 76 ASD cases and 76 controls were calculated by sample size calculation software to provide 90% statistical power (1-β) and a 2-tailed 5% α level.…”

Section: Methodsmentioning

confidence: 99%

Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder

Li,

Liu,

Huang

et al. 2023

Gut Microbes

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Our previous work revealed that unbalanced dietary intake was an important independent factor associated with constipation and gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Growing evidence has shown the alterations in the gut microbiota and gut microbiota-derived metabolites in ASD. However, how the altered microbiota might affect the associations between unbalanced diets and GI symptoms in ASD remains unknown. We analyzed microbiome and metabolomics data in 90 ASD and 90 typically developing (TD) children based on 16S rRNA and untargeted metabolomics, together with dietary intake and GI symptoms assessment. We found that there existed 11 altered gut microbiota (FDR-corrected P-value <0.05) and 397 altered metabolites (P-value <0.05) in children with ASD compared with TD children. Among the 11 altered microbiota, the Turicibacter , Coprococcus 1 , and Lachnospiraceae FCS020 group were positively correlated with constipation (FDR-corrected P-value <0.25). The Eggerthellaceae was positively correlated with total GI symptoms (FDR-corrected P-value <0.25). More importantly, three increased microbiota including Turicibacter , Coprococcus 1 , and Eggerthellaceae positively modulated the associations of unbalanced dietary intake with constipation and total GI symptoms, and the decreased Clostridium sp. BR31 negatively modulated their associations in ASD children (P-value <0.05). Together, the altered microbiota strengthens the relationship between unbalanced dietary intake and GI symptoms. Among the altered metabolites, ten metabolites derived from microbiota ( Turicibacter , Coprococcus 1 , Eggerthellaceae, and Clostridium sp. BR31 ) were screened out, enriched in eight metabolic pathways, and were identified to correlate with constipation and total GI symptoms in ASD children (FDR-corrected P-value <0.25). These metabolomics findings further support the modulating role of gut microbiota on the associations of unbalanced dietary intake with GI symptoms. Collectively, our research provides insights into the relationship between diet, the gut microbiota, and GI symptoms in children with ASD.

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“…One (41) of these included only ASD patients with GI symptoms and was unable to calculate the prevalence of GI disturbance, so it was excluded from the meta-analysis. Thus, data from 19 studies (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) were ultimately included. The cumulative prevalence was 55% (95% CI: 0.45, 0.66), and more than half of the children with ASD had at least one gastrointestinal disorder, I 2 = 97.93%, p < 0.05 (Figure 6).…”

Section: Prevalence Of Total Gi Symptoms In Children With Asdmentioning

confidence: 99%

Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis

Gan

Zhang

et al. 2023

Front. Pediatr.

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BackgroundGastrointestinal (GI) symptoms are frequently experienced by children with autism spectrum disorder (ASD), and these symptoms cause difficulties for these children and their families. However, studies of GI symptom prevalence differ significantly. This meta-analysis aimed to analyze the prevalence of GI symptoms in children with ASD.Methods and findingsPubMed, Scopus, Web of Science, EMBASE were electronically searched to collect all literature on gastrointestinal symptoms of children with ASD collected through questionnaires or scales from January 2012 to May 2021. Four researchers independently scanned the literature and extracted information on general characteristics. First author name, year of publication, geographical location, type of study, sample sizes of ASD and control (if any) children, sex and average age, number of GI cases, number of GI symptoms, GI assessment tools (gastrointestinal symptoms scale), autism diagnosis methods, and other necessary data were collected and analyzed using Stata V16. The questionnaires included the Rome, 6-GSI, GIQ, GSRS, GSIQ, ADI-R, PedsQL-GI, parent-report, GI-related, and self-administered questionnaires. Compared with typically developing (TD) children, the odds ratio for In children with ASD with at least one GI symptom was 3.64, and the total prevalence was 55%. The cumulative prevalence rates of various symptoms were summarized, showing that 37% of children with ASD had constipation, 21% had abdominal pain, 19% had diarrhea, 8% had vomiting, and 23% had abdominal distension.ConclusionsThe results of this meta-analysis on GI symptoms in ASD show that patients with ASD are more likely to develop symptoms than TD children. The prevalence of GI symptoms in In children with ASD was 55%.Systematic Review Registrationwww.crd.york.ac.uk/PROSPERO, identifier, #CRD42017080579.

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<p>Gastrointestinal Problems in Chinese Children with Autism Spectrum Disorder</p>

Cited by 5 publications

References 47 publications

An elevated anxiety level among prepubertal autistic boys with non‐treatment‐seeking functional gastrointestinal disorders: A case–control study

An elevated anxiety level among prepubertal autistic boys with non‐treatment‐seeking functional gastrointestinal disorders: A case–control study

Multi-omics analyses demonstrate the modulating role of gut microbiota on the associations of unbalanced dietary intake with gastrointestinal symptoms in children with autism spectrum disorder

Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis

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