&lt;p&gt;Further considerations on rotavirus vaccination and seizure-related hospitalization rates&lt;/p&gt;

TIPICO is an expert meeting and workshop that aims to provide the most recent evidence in the field of infectious diseases and vaccination. The 10th Interactive Infectious Disease TIPICO workshop took place in Santiago de Compostela, Spain, on November 21–22, 2019. Cutting-edge advances in vaccination against respiratory syncytial virus, Streptococcus pneumoniae , rotavirus, human papillomavirus, Neisseria meningitidis , influenza virus, and Salmonella Typhi were discussed. Furthermore, heterologous vaccine effects were updated, including the use of Bacillus Calmette-Guérin (BCG) vaccine as potential treatment for type 1 diabetes. Finally, the workshop also included presentations and discussion on emergent virus and zoonoses, vaccine resilience, building and sustaining confidence in vaccination, approaches to vaccine decision-making, pros and cons of compulsory vaccination, the latest advances in decoding infectious diseases by RNA gene signatures, and the application of big data approaches.

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“… 124 The reduction in that population has been reported to be greater than 40% compared to unvaccinated children. 32 , 125 …”

Section: Heterologous Vaccine Effects: Growing Evidencementioning

confidence: 99%

TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines

Rivero‐Calle

Gómez-Rial

Bont

et al. 2020

Human Vaccines & Immunotherapeutics

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“…28 Both Rotarix™ and RotaTeq® have been found to confer protection against several RV genotypes other than those included in the vaccine, as evidenced by real-world data from Finland 29 and the USA 30 ; see also. 31,32,33 In Dr. Vesikari's words, the effectiveness of the vaccine may depend mainly on dosing schedules instead of on genotypespecific protection. In Europe, RV vaccination programs have been successful in several countries, including Belgium, where vaccination coverage with Rotarix™ (RV1) is estimated at 90% 34 or the UK, with one of the highest vaccination coverage rates reported (Rotarix™, RV1).…”

Section: Rotavirus Vaccines Do Workmentioning

confidence: 99%

TIPICO IX: report of the 9^th interactive infectious disease workshop on infectious diseases and vaccines

Rivero‐Calle

Gómez-Rial

Bont

et al. 2019

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

The Ninth Interactive Infectious Disease workshop TIPICO was held on November 22-23, 2018, in Santiago de Compostela, Spain. This 2-day academic experience addressed current and topical issues in the field of infectious diseases and vaccination. Summary findings of the meeting include: cervical cancer elimination will be possible in the future, thanks to the implementation of global vaccination action plans in combination with appropriate screening interventions. The introduction of appropriate immunization programs is key to maintain the success of current effective vaccines such as those against meningococcal disease or rotavirus infection. Additionally, reduced dose schedules might improve the efficiency of some vaccines (i.e., PCV13). New vaccines to improve current preventive alternatives are under development (e.g., against tuberculosis or influenza virus), while others to protect against infectious diseases with no current available vaccines (e.g., enterovirus, parechovirus and flaviviruses) need to be developed. Vaccinomics will be fundamental in this process, while infectomics will allow the application of precision medicine. Further research is also required to understand the impact of heterologous vaccine effects. Finally, vaccination requires education at all levels (individuals, community, healthcare professionals) to ensure its success by helping to overcome major barriers such as vaccine hesitancy and false contraindications.

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“…The development of future RV vaccines or the improvement of current formulations is limited by our incomplete knowledge of the mechanisms responsible for RV pathogenesis and the host susceptibility (9). Possible heterologous effects of RV vaccination are also the focus of attention (see (10)(11)(12) and references therein). It has been recently reported that RV infection is able to provoke global changes in the transcriptome of infected cells to evade the innate host response; likewise, the host develops mechanisms to avoid viral invasion, including a strong inhibition of glycophorin genes (13).…”

Section: Introductionmentioning

confidence: 99%

Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants’ Mimics Wild Type Infection

et al. 2021

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BackgroundRotavirus (RV) is an enteric pathogen that has devastating impact on childhood morbidity and mortality worldwide. The immunologic mechanism underlying the protection achieved after RV vaccination is not yet fully understood.MethodsWe compared the transcriptome of children affected by community-acquired RV infection and children immunized with a live attenuated RV vaccine (RotaTeq®).ResultsRV vaccination mimics the wild type infection causing similar changes in children’s transcriptome, including transcripts associated with cell cycle, diarrhea, nausea, vomiting, intussusception, and abnormal morphology of midgut. A machine learning approach allowed to detect a combination of nine-transcripts that differentiates vaccinated from convalescent-naturally infected children (AUC: 90%; 95%CI: 70–100) and distinguishes between acute-infected and healthy control children (in both cases, AUC: 100%; 95%CI: 100–100). We identified a miRNA hsa-mir-149 that seems to play a role in the host defense against viral pathogens and may have an antiviral role.DiscussionOur findings might shed further light in the understanding of RV infection, its functional link to intussusception causes, as well as guide development of antiviral treatments and safer and more effective vaccines. The nine-transcript signature may constitute a marker of vaccine protection and helps to differentiate vaccinated from naturally infected or susceptible children.

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<p>Further considerations on rotavirus vaccination and seizure-related hospitalization rates</p>

Cited by 5 publications

References 7 publications

TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines

TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines

TIPICO IX: report of the 9^th interactive infectious disease workshop on infectious diseases and vaccines

Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants’ Mimics Wild Type Infection

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<p>Further considerations on rotavirus vaccination and seizure-related hospitalization rates</p>

Cited by 5 publications

References 7 publications

TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines

TIPICO X: report of the 10th interactive infectious disease workshop on infectious diseases and vaccines

TIPICO IX: report of the 9th interactive infectious disease workshop on infectious diseases and vaccines

Host Transcriptomic Response Following Administration of Rotavirus Vaccine in Infants’ Mimics Wild Type Infection

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Product

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TIPICO IX: report of the 9^th interactive infectious disease workshop on infectious diseases and vaccines