&lt;p&gt;Free Fatty Acids Promote the Development of Prostate Cancer by Upregulating Peroxisome Proliferator-Activated Receptor Gamma&lt;/p&gt;

Ha, Xiaodan; Wang, Jingzhou; Chen, Keru; Deng, Yuchun; Zhang, Xueting; Feng, Jiale; Li, Xue; Zhu, Jiaojiao; Ma, Yong; Qiu, Tongtong; Wang, Cuizhe; Xie, Jingui; Zhang, Jun

doi:10.2147/cmar.s236301

Cited by 17 publications

(22 citation statements)

References 58 publications

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“…Upon ligand binding, PPAR-γ can induce an increase in CEA-dependent intercellular adhesion ( 10 ). In concert, the up-regulated expression of vascular endothelial growth factor A (VEGF-A) and Vimentin, a major intermediate filament protein that plays an important role in cell adhesion, migration, angiogenesis and neurite extension, is relate to the activation of PPAR-γ ( 52 ). Additionally, the inactivation of PPAR-γ by antagonists interferes with cancer cells’ adhesion to the extracellular matrix, disrupting survival signals, and thus inducing anoikis, a special form of apoptosis ( 40 ).…”

Section: Functions Of Ppar-γmentioning

confidence: 99%

PPAR-γ Modulators as Current and Potential Cancer Treatments

Chi

Wang

et al. 2021

Front. Oncol.

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Worldwide, cancer has become one of the leading causes of mortality. Peroxisome Proliferator-Activated Receptors (PPARs) is a family of critical sensors of lipids as well as regulators of diverse metabolic pathways. They are also equipped with the capability to promote eNOS activation, regulate immunity and inflammation response. Aside from the established properties, emerging discoveries are also made in PPAR’s functions in the cancer field. All considerations are given, there exists great potential in PPAR modulators which may hold in the management of cancers. In particular, PPAR-γ, the most expressed subtype in adipose tissues with two isoforms of different tissue distribution, has been proven to be able to inhibit cell proliferation, induce cell cycle termination and apoptosis of multiple cancer cells, promote intercellular adhesion, and cripple the inflamed state of tumor microenvironment, both on transcriptional and protein level. However, despite the multi-functionalities, the safety of PPAR-γ modulators is still of clinical concern in terms of dosage, drug interactions, cancer types and stages, etc. This review aims to consolidate the functions of PPAR-γ, the current and potential applications of PPAR-γ modulators, and the challenges in applying PPAR-γ modulators to cancer treatment, in both laboratory and clinical settings. We sincerely hope to provide a comprehensive perspective on the prospect of PPAR-γ applicability in the field of cancer treatment.

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Section: Functions Of Ppar-γmentioning

confidence: 99%

PPAR-γ Modulators as Current and Potential Cancer Treatments

Chi

Wang

et al. 2021

Front. Oncol.

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“…Recent studies suggest that fatty acids, either from de novo synthesis or exogenous supply, promote PCa invasion and metastasis by upregulating PPARγ signaling [ 48 , 140 ]. Both FAS, which catalyzes de novo synthesis of fatty acids, and MAGL, which hydrolyzes triglycerides to fatty acids, are implicated in cellular fatty acid accumulation and cancer aggressiveness and metastasis [ 48 , 81 , 141 ].…”

Section: The Molecular Pathways Underlying Fabp-induced Pca Metastmentioning

confidence: 99%

An Amplified Fatty Acid-Binding Protein Gene Cluster in Prostate Cancer: Emerging Roles in Lipid Metabolism and Metastasis

Liu

Godbout

2020

Cancers

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Treatment for early stage and localized prostate cancer (PCa) is highly effective. Patient survival, however, drops dramatically upon metastasis due to drug resistance and cancer recurrence. The molecular mechanisms underlying PCa metastasis are complex and remain unclear. It is therefore crucial to decipher the key genetic alterations and relevant molecular pathways driving PCa metastatic progression so that predictive biomarkers and precise therapeutic targets can be developed. Through PCa cohort analysis, we found that a fatty acid-binding protein (FABP) gene cluster (containing five FABP family members) is preferentially amplified and overexpressed in metastatic PCa. All five FABP genes reside on chromosome 8 at 8q21.13, a chromosomal region frequently amplified in PCa. There is emerging evidence that these FABPs promote metastasis through distinct biological actions and molecular pathways. In this review, we discuss how these FABPs may serve as drivers/promoters for PCa metastatic transformation using patient cohort analysis combined with a review of the literature.

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“…Free fatty acids (FFAs) have been shown to play a role in the pathogenesis of prostate cancer by altering the metabolism and the proliferation and invasive behavior of prostate cancer cells. 16 Accordingly, the serum of patients with prostate cancer features abnormal levels of FFAs. 16 Interestingly, there is a continuum of increased levels of serum FFAs along with progression from prostatitis to benign prostate hyperplasia and prostate cancer.…”

Section: The Special Issue At a Glancementioning

confidence: 99%

“… 16 Accordingly, the serum of patients with prostate cancer features abnormal levels of FFAs. 16 Interestingly, there is a continuum of increased levels of serum FFAs along with progression from prostatitis to benign prostate hyperplasia and prostate cancer. This suggests that inhibition of de novo FFA synthesis could be a valuable strategy to prevent the pathogenesis and progression of prostate cancer.…”

Section: The Special Issue At a Glancementioning

confidence: 99%

Nutraceuticals and diet in human health and disease. The special issue at a glance

Isidoro

2020

Journal of Traditional and Complementary Medicine

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This first Special Issue collects fifteen original research and up-to-date review articles addressing the beneficial properties of herbal products, nutrient supplements, dietary regimens, and functional food for the complementary therapy of human pathologies. In these articles, renowned scholars present and discuss the curative effects and the molecular mechanisms of action of nutraceuticals, medicinal herbs, and dietary regimens that have been proven effective in the treatment of cancers, metabolic syndrome, fatty liver disease, hearth arrythmia and neurodegenerative disorders.

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<p>Free Fatty Acids Promote the Development of Prostate Cancer by Upregulating Peroxisome Proliferator-Activated Receptor Gamma</p>

Cited by 17 publications

References 58 publications

PPAR-γ Modulators as Current and Potential Cancer Treatments

PPAR-γ Modulators as Current and Potential Cancer Treatments

An Amplified Fatty Acid-Binding Protein Gene Cluster in Prostate Cancer: Emerging Roles in Lipid Metabolism and Metastasis

Nutraceuticals and diet in human health and disease. The special issue at a glance

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