&lt;p&gt;Formulation of Aceclofenac Tablets Using Nanosuspension as Granulating Agent: An Attempt to Enhance Dissolution Rate and Oral Bioavailability&lt;/p&gt;

Rahim, Haroon; Sadiq, Abdul; Ullah, Riaz; Bari, Ahmed; Amin, Fazli; Farooq, Umar; Jan, Naeem Ullah; Mahmood, Hafiz Majid

doi:10.2147/ijn.s270746

Cited by 8 publications

(4 citation statements)

References 30 publications

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“…Moreover using various types of polymers, the crystallinity of the drug was modified into an amorphous state during the preparation of solid dispersions, and pH of the microenvironment was regulated by Na 2 Co 3 as a pH modifier, which improved solubility [37]. (aromatic C-C stretching skeleton vibration), 1507 cm -1 (N-H in plane bending), 1344 cm -1 ( O-H in plane bending), 1287 cm -1 (C-N aromatic amine), 963 cm -1 (O-H out plane bending), and 749 cm -1 (aromatic C-C stretching skeleton vibration) [33]. FTIR Spectrum of PVP K30 had a characteristic absorption band at 1655 cm -1 for carbonyl group is responsible for this.…”

Section: Drug Solubility Study and Choosing Of An Alkalizing Agent Fo...mentioning

confidence: 99%

“…Aceclofenac (AFC) (2-[(2,6-dichlorophenyl) amine] phenylacetoxyacetic acid) is a new generational non-steroidal anti-inflammatory drug (NSAID) that is thought to be a better option for diclofenac and other NSAIDs in term of gastrointestinal safety [29,30]. The fundamental issue with AFC's therapeutic response in an orally administered dose form is its low water solubility, as it is a biopharmaceutical classification system (BCS) Class II [30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

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A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Ebraheem¹,

El-Gawad

Girgis

2022

J. Pharm. Res. Int.

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The major objective of the current study is to implement a plan to enhance the dissolution rate and oral bioavailability of a poorly water-soluble aceclofenac. The drug is classified according to the biopharmaceutical classification system as class II drug. Amorphous alkalinized aceclofenac solid dispersion was formulated as a ternary mixture. This mixture was prepared by introducing polymeric carriers [polyvinylpyrrolidone, Hydroxy propyl beta cyclodextrin or Polyethylene glycol] and an alkalizer (Na2CO3) by applying the solvent evaporation method. Optimum formulations were compressed into tablets that were subjected to in-vitro studies compared to the market product Bristaflam and free drug containing one. Finally, tablets were assessed for stability studies and carrageenan-induced rat paw edema treatment to evaluate potentiated anti-inflammatory efficacy. Results showed that optimum amorphous alkalinized aceclofenac solid dispersion formulations containing polyvinylpyrrolidone K30 or Hydroxy propyl beta cyclodextrin in 1:5 ratio have significant in-vitro dissolution improvement (>90% in 10 min) compared to untreated aceclofenac. Solid-state characterization emphasized the conversion of the crystalline drug into the amorphous form with no drug−polymers interactions. Stability and dissolution studies ensured that tablets containing amorphous alkalinized solid dispersions were stable with strikingly improving dissolution behavior compared to Bristaflam or free drug containing tablets. Moreover, regarding anti-inflammatory activity against carrageenan induced paw edema, and histopathological examination, we concluded that amorphous alkalinized solid dispersions containing tablets are a promising approach to enhance the dissolution rate and oral bioavailability and hence anti-inflammatory efficacy of aceclofenac.

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Section: Drug Solubility Study and Choosing Of An Alkalizing Agent Fo...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Ebraheem¹,

El-Gawad

Girgis

2022

J. Pharm. Res. Int.

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“…The sample was mixed with a suitable amount of KBr and converted into pellets using KBr press at 15 tons hydraulic pressure. The IR scanning of samples was done in between 4000 and 400 cm -1 and spectrum observed for any occurrence and disappearance of characteristic drug peak and compared with the standard references 23 .…”

Section: Compatibility Study Of Drug and Polymer (Ftir)mentioning

confidence: 99%

“…Complete sink condition was maintained by replacing the same volume of fresh dissolution medium after each sampling. The samples were diluted to a suitable volume with phosphate buffer, and the absorbance was recorded at 273.5 nm using a UV spectrophotometer 23 .…”

Section: Determination Of In Vitro Dissolution Profilementioning

confidence: 99%

Formulation and Evaluation of Sustained Release Matrix Tablets of Aceclofenac

Singh

Shrivastava

Kumar³

et al. 2021

Borneo J Pharm

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This study aimed to improve the dissolution rate of aceclofenac and release the drug in a controlled manner over a period of 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). Matrix tablets were prepared by wet granulation method using different hydrophilic polymers (HPMC/guar gum). Tablets were evaluated for in vitro drug release profile in phosphate buffer with pH 6.8 (without enzymes). The thickness and hardness of prepared tablets were 3.23 ± 0.035 to 3.28 ± 0.008 mm and 3.26 ± 0.115 to 3.60 ± 0.200 kg/cm2, respectively. The friability was within the acceptable limits of pharmacopoeial specifications (0.31 to 0.71%), which indicates the good mechanical strength of the tablets. Drug release was retarded with an increase in polymer concentration due to the gelling property of polymers. The in vitro drug release from the proposed system was best explained by Higuchi’s model, indicating that drug release from tablets displayed a diffusion-controlled mechanism. The results clearly indicate that guar gum could be a potential hydrophilic carrier in developing oral controlled drug delivery systems. Based on the study results, formulations F8 was selected as the best formulation.

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Design and Development of Immediate Release Pellets Formulation Containing Co Amorphous Mixture of Aceclofenac: In-Vitro and In-Vivo Study

Chishti,

Pathan,

Dehghan

et al. 2024

J Pharm Innov

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<p>Formulation of Aceclofenac Tablets Using Nanosuspension as Granulating Agent: An Attempt to Enhance Dissolution Rate and Oral Bioavailability</p>

Cited by 8 publications

References 30 publications

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

A Promising Ternary Solid Dispersion of Aceclofenac Containing Tablet with Enhanced Dissolution, and Potentiated Anti-inflammatory Efficacy

Formulation and Evaluation of Sustained Release Matrix Tablets of Aceclofenac

Design and Development of Immediate Release Pellets Formulation Containing Co Amorphous Mixture of Aceclofenac: In-Vitro and In-Vivo Study

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