&lt;p&gt;Factors Associated with Oral Candidiasis in People Living with HIV/AIDS: A Case Control Study&lt;/p&gt;

Suryana, Ketut; Suharsono, Hamong; Antara, I Gede Putu Jarwa

doi:10.2147/hiv.s236304

Cited by 30 publications

(48 citation statements)

References 31 publications

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“…We found that increasing age (≥50 years) was significantly associated with OPC among COVID‐19 patients. In a cross‐sectional study, Suryana et al revealed that increasing age ( P = .03) was significantly identified risk factor in HIV patients 32 . Elderly patients were shown to have significantly lower activity levels of protective salivary innate defences 33 .…”

Section: Discussionmentioning

confidence: 99%

Oropharyngeal candidiasis in hospitalised COVID‐19 patients from Iran: Species identification and antifungal susceptibility pattern

Salehi

Ahmadikia

Mahmoudi

et al. 2020

Mycoses

131

169

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Background Emergence of coronavirus disease 2019 (COVID‐19) is a major healthcare threat. Apparently, the novel coronavirus (SARS‐CoV‐2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID‐19 patients with a list of attributable risk factors for oral infections has not yet been investigated. Objectives We here aim to investigate the prevalence, causative agents, and antifungal susceptibility pattern of OPC in Iranian COVID‐19 patients. Patients and Methods A total of 53 hospitalized COVID‐19 patients with OPC were studied. Relevant clinical data were mined. Strain identification was performed by 21‐plex PCR and sequencing of the internal transcribed spacer region (ITS1‐5.8S‐ITS2). Antifungal susceptibility testing to fluconazole, itraconazole, voriconazole, amphotericin B, caspofungin, micafungin and anidulafungin was performed according to the CLSI broth dilution method. Results In 53 COVID‐19 patients with OPC, cardiovascular diseases (52.83 %), and diabetes (37.7 %) were the principal underlying conditions. The most common risk factor was lymphopenia (71%). In total, 65 Candida isolates causing OPC were recovered. C. albicans (70.7%) was the most common, followed by C. glabrata (10.7%), C. dubliniensis (9.2%), C. parapsilosis sensu stricto (4.6%), C. tropicalis (3%), and Pichia kudriavzevii (= C. krusei , 1.5%). Majority of the Candida isolates were susceptible to all three classes of antifungal drugs. Conclusion Our data clarified some concerns regarding the occurrence of OPC in Iranian COVID‐19 patients. Further studies should be conducted to design an appropriate prophylaxis program and improve management of OPC in critically ill COVID‐19 patients.

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Section: Discussionmentioning

confidence: 99%

Oropharyngeal candidiasis in hospitalised COVID‐19 patients from Iran: Species identification and antifungal susceptibility pattern

Salehi

Ahmadikia

Mahmoudi

et al. 2020

Mycoses

131

169

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“…), autoimmune diseases (Sjögren syndrome, etc. ), HIV, and primary immunodeficiencies [ 57 , 58 , 59 ].…”

Section: Clinical Manifestations Of Candidiasismentioning

confidence: 99%

“…In HIV infection/AIDS, candidosis is an early sign of immunodeficiency and can indicate the immune status and disease progression in such patients [ 59 , 60 ].…”

Section: Clinical Manifestations Of Candidiasismentioning

confidence: 99%

Candida albicans—The Virulence Factors and Clinical Manifestations of Infection

Talapko

Juzbašić

Matijević³

et al. 2021

JoF

305

161

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Candida albicans is a common commensal fungus that colonizes the oropharyngeal cavity, gastrointestinal and vaginal tract, and healthy individuals’ skin. In 50% of the population, C. albicans is part of the normal flora of the microbiota. The various clinical manifestations of Candida species range from localized, superficial mucocutaneous disorders to invasive diseases that involve multiple organ systems and are life-threatening. From systemic and local to hereditary and environmental, diverse factors lead to disturbances in Candida’s normal homeostasis, resulting in a transition from normal flora to pathogenic and opportunistic infections. The transition in the pathophysiology of the onset and progression of infection is also influenced by Candida’s virulence traits that lead to the development of candidiasis. Oral candidiasis has a wide range of clinical manifestations, divided into primary and secondary candidiasis. The main supply of C. albicans in the body is located in the gastrointestinal tract, and the development of infections occurs due to dysbiosis of the residential microbiota, immune dysfunction, and damage to the muco-intestinal barrier. The presence of C. albicans in the blood is associated with candidemia–invasive Candida infections. The commensal relationship exists as long as there is a balance between the host immune system and the virulence factors of C. albicans. This paper presents the virulence traits of Candida albicans and clinical manifestations of specific candidiasis.

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“…Warto jednak nadmienić, że rozpowszechnienie kandydozy jamy ustnej wśród zakażonych wirusem HIV zmniejszyło się znacząco wraz z wprowadzeniem schematów wysoce aktywnej terapii przeciwretrowirusowej. [39][40][41] Mushi i wsp. 42 donoszą o zwiększonej częstości izolacji gatunków C. non-albicans o wyższej wirulencji.…”

Section: Dyskusjaunclassified

Occurrence of risk factors for oral mucosa candidiasis and their frequency – retrospective analysis

Bochniak¹,

Cydejko²,

Kusiak³

et al. 2020

Prosthodontics

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Wprowadzenie. Kandydoza jest jedną z najczęstszych schorzeń błony śluzowej jamy ustnej. Dotyczy wszystkich grup wiekowych, w szczególności populacji ludzi starszych. Różne gatunki grzybów drożdżopodobnych stanowią składową naturalnej mikroflory jamy ustnej. Drogę klinicznie jawnemu zakażeniu toruje szereg czynników ryzyka zarówno miejscowych, jak i ogólnoustrojowych, naruszających równowagę biologiczną środowiska jamy ustnej. Cel pracy. Celem pracy była retrospektywna ocena częstości występowania potencjalnych czynników ryzyka infekcji grzybiczej wśród pacjentów ze zdiagnozowaną kandydozą błony śluzowej jamy ustnej. Materiał i metody. Grupę badaną stanowiło 228 osób (152 kobiety i 76 mężczyzn), średnia wieku 60.9 ± 13.5 lat, u których zdiagnozowano kandydozę błony śluzowej jamy ustnej. Przeprowadzono retrospektywną analizę dokumentacji medycznej, biorąc pod uwagę dane z wywiadu medycznego i badania przedmiotowego dotyczące potencjalnych czynników ryzyka infekcji grzybiczych. Częstość występowania czynników ryzyka kandydozy błony śluzowej jamy ustnej-analiza retrospektywna Occurrence of risk factors for oral mucosa candidiasis and their frequency-retrospective analysis

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<p>Factors Associated with Oral Candidiasis in People Living with HIV/AIDS: A Case Control Study</p>

Cited by 30 publications

References 31 publications

Oropharyngeal candidiasis in hospitalised COVID‐19 patients from Iran: Species identification and antifungal susceptibility pattern

Oropharyngeal candidiasis in hospitalised COVID‐19 patients from Iran: Species identification and antifungal susceptibility pattern

Candida albicans—The Virulence Factors and Clinical Manifestations of Infection

Occurrence of risk factors for oral mucosa candidiasis and their frequency – retrospective analysis

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