<p>Extent of coronary artery disease is associated with myocardial infarction and mortality in patients with diabetes mellitus</p>

Abstract

Purpose: We examined risk of myocardial infarction and all-cause death associated with the extent of coronary artery disease ascertained by coronary angiography in patients with diabetes mellitus. We hypothesized that risks of myocardial infarction and death were associated with extent of coronary artery disease in diabetes patients. Patients and methods: We conducted a cohort study of patients with type 1 and type 2 diabetes, who underwent coronary angiography from 2004 to 2012. Patients were stratified according to extent of coronary artery disease: 0-, 1-, 2- or 3-vessel disease or diffuse vessel disease. Endpoints were myocardial infarction, all-cause death, and major adverse cardiovascular events (MACE), defined as the composite of myocardial infarction, cardiac death, or ischemic stroke. Adjusted incidence and mortality rate ratios (IRRs adj ) were calculated using patients with 0-vessel disease as the reference group. Median follow-up was 3 years for a total of 45,164 person-years. Results: The study included 12,594 diabetes patients. Of these, 3,147 (25.0%) had 0-vessel disease, 1,195 (9.5%) had diffuse vessel disease, 3,001 (23.8%) had 1-vessel disease, 2,220 (17.6%) had 2-vessel disease, and 3,031 (24.1%) had 3-vessel disease. The myocardial infarction rate was 0.4 per 100 person-years (95% CI: 0.3–0.5) in patients with 0-vessel disease. Using patients with 0-vessel disease as reference, the risk of myocardial infarction increased according to the number of diseased vessels (diffuse vessel disease: 1.4 per 100 person-years, IRR adj 3.87, 95% CI: 2.41–6.23; 1-vessel disease: 1.9 per 100 person-years, IRR adj 4.99, 95% CI: 3.33–7.46; 2-vessel disease: 2.7 per 100 person-years, IRR adj 7.14, 95% CI: 4.78–10.65; and 3-vessel disease: 4.3 per 100 person-years, IRR adj 11.42, 95% CI: 7.76–16.82; p trend <0.001). Similar associations were observed for all-cause death and MACE. Conclusion: The extent of coronary artery disease is a major risk factor for myocardial infarction and death in patients with diabetes mellitus.

The C allele of the reactive oxygen species modulator 1 (ROMO1) polymorphism rs6060566 is a biomarker predicting coronary artery stenosis in Slovenian subjects with type 2 diabetes mellitus

“…At first glance, it seems that the frequency of subjects with MI increased with the number of involved vessels. Our results are partly supported by in-depth study conducted on 12.594 diabetes patients by Gyldenkerne et al [ 21 ] who found that the extent of CAD is a major risk factor for MI and death in patients with DM. We could not confirm this increased risk for MI in a group of subjects with 3 VD, most likely because of the small sample size.…”

Reactive Oxygen Species Modulator-1 (ROMO-1) Polymorphism Rs6060566 and The Risk of Myocardial Infarction in Slovenian Subjects With Type 2 Diabetes Mellitus

“…At rst glance, it seems that the frequency of subjects with MI increased with the number of involved vessels. Our results are partly supported by in-depth study conducted on 12.594 diabetes patients by Gyldenkerne et al [20] who found that the extent of CAD is a major risk factor for MI and death in patients with DM. We could not con rm this increased risk for MI in a group of subjects with 3 VD, most likely because of small sample size.…”

Choosing Antithrombotic Therapy in Patients with Coronary Heart Disease and Type 2 Diabetes Mellitus: How to Reduce the Risk of Death

“…В когортное наблюдательное исследование C. Gyldenkerne и соавт. были включены 12 594 больных СД 2-го ти-па и ИБС, подтвержденной данными коронарографии [14]. Исследователи рассчитали риск развития ИМ, смерти и тяжелых сердечно-сосудистых событий в зависимости от числа поражения артерий в течение 3 лет наблюдения.…”