&lt;p&gt;Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis&lt;/p&gt;

Tang, Jiayou; Jin, Lü; Yang, Liu; Li, Lanlan; Ma, Yanyan; Lu, Linhe; Ma, Jie; Ding, Peng; Yang, Xiangdong; Liu, Jincheng

doi:10.2147/dddt.s239546

Cited by 34 publications

(18 citation statements)

References 45 publications

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“…They hypothesized that hucMSC-derived exosomes may protect cardiomyocytes from apoptosis by regulating the expression of the Bcl-2 family and promote the tube formation and migration of vascular endothelial cells ( 68 ). Exosomes secreted by hucMSCs protect cardiomyocytes from anoxia-reoxygenation injury ( 69 ). Similar studies are equally effective in mouse ischemia/reperfusion injury models ( 70 ).…”

Section: Anti-inflammatory and Tissue Repair Promoting Effects Of Mscmentioning

confidence: 99%

The Unique Immunomodulatory Properties of MSC-Derived Exosomes in Organ Transplantation

et al. 2021

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Methods for suppressing the host immune system over the long term and improving transplantation tolerance remain a primary issue in organ transplantation. Cell therapy is an emerging therapeutic strategy for immunomodulation after transplantation. Mesenchymal stem cells (MSCs) are adult multipotent stem cells with wide differentiation potential and immunosuppressive properties, which are mostly used in regenerative medicine and immunomodulation. In addition, emerging research suggests that MSC-derived exosomes have the same therapeutic effects as MSCs in many diseases, while avoiding many of the risks associated with cell transplantation. Their unique immunomodulatory properties are particularly important in the immune system-overactive graft environment. In this paper, we review the effects of MSC-derived exosomes in the immune regulation mechanism after organ transplantation and graft-versus-host disease (GvHD) from various perspectives, including immunosuppression, influencing factors, anti-inflammatory properties, mediation of tissue repair and regeneration, and the induction of immune tolerance. At present, the great potential of MSC-derived exosomes in immunotherapy has attracted a great deal of attention. Furthermore, we discuss the latest insights on MSC-derived exosomes in organ transplantation and GvHD, especially its commercial production concepts, which aim to provide new strategies for improving the prognosis of organ transplantation patients.

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Section: Anti-inflammatory and Tissue Repair Promoting Effects Of Mscmentioning

confidence: 99%

The Unique Immunomodulatory Properties of MSC-Derived Exosomes in Organ Transplantation

et al. 2021

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“…And pyroptosis plays a pivotal role in the pathogenesis of various cardiovascular diseases, especially MI [23]. Suppressing NLRP3-mediated pyroptosis pathway protects myocardial ischemia-reperfusion injury [24][25][26]. In our study, ColCaNPs could help colchicine attenuate cardiac pyroptosis, and at the same time, colchicine-containing calcium carbonate nanoparticles signi cantly inhibited the expression of TLR4, NFκB and NLRP3 (Fig.…”

Section: Discussionmentioning

confidence: 55%

Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation

Wang

Peng

Song

et al. 2021

Preprint

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Purpose Anti-inflammatory therapy is important for reducing myocardial injury after acute myocardial infarction (MI). New anti-inflammatory drugs and their mechanism are necessary to be explored to improve the clinical efficacy. We aimed to improve the efficacy of colchicine on attenuating MI injury by nano-drug delivery systems, and to investigate the mechanism of anti-inflammatory. Methods Colchicine-containing delivery system based on calcium carbonate nanoparticles (ColCaNPs) was synthesized. The protection against MI by ColCaNPs was evaluated using an in vivo rat model established by ligating the left anterior descending coronary artery. Macrophage polarization and the levels of inflammatory cytokines were determined using immunohistochemistry, western blot and ELISA analysis. Results ColCaNPs treatment showed about a 45% reduction in myocardial infarct size and attenuating myocardial fibrosis compared with groups without drug intervention after MI. Furthmore, ColCaNPs significantly decreased the levels of CRP, TNF-α and IL-1β in serum and the expression of proinflammatory cytokine in myocardial tissues after MI (p < 0.05). We also found that ColCaNPs notably restrained pyroptosis, and inhibited inflammatory response by modulating on M1/M2 macrophage polarization and suppressing TLR4/NFκB/NLRP3 signal pathway. Conculsion Colchicine-containing nanoparticles can protect against MI injury in a clinically relevant rat model by reducing inflammation. In addition, calcium carbonate nanoparticles can increase the cardioprotective effects of colchicine.

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“…The mechanism by which MSCs and secretome inhibit pyroptosis has been more deeply studied in other disease models. Several new findings showed that MSCs exosomes inhibited NLRP3 expression and pyroptosis of cardiomyocytes and myocardial infarction by delivering miRNA-320b or long non-coding RNA (lncRNA) KLF3-AS1 (Mao et al, 2019;Tang et al, 2020). Liu et al (2020c) found that cotransplantation of a chitosan thermosensitive hydrogel with BMSCs contributed to a better outcome in myocardial infarction, which is manifested by the inhibition of inflammatory response and alleviation of pyroptosis in vascular endothelial cells.…”

Section: Mscs and Pyroptosis In Ischemic Strokementioning

confidence: 99%

Oxidative Stress, Inflammation, and Autophagy: Potential Targets of Mesenchymal Stem Cells-Based Therapies in Ischemic Stroke

Liu

Huang

et al. 2021

Front. Neurosci.

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Ischemic stroke is a leading cause of death worldwide; currently available treatment approaches for ischemic stroke are to restore blood flow, which reduce disability but are time limited. The interruption of blood flow in ischemic stroke contributes to intricate pathophysiological processes. Oxidative stress and inflammatory activity are two early events in the cascade of cerebral ischemic injury. These two factors are reciprocal causation and directly trigger the development of autophagy. Appropriate autophagy activity contributes to brain recovery by reducing oxidative stress and inflammatory activity, while autophagy dysfunction aggravates cerebral injury. Abundant evidence demonstrates the beneficial impact of mesenchymal stem cells (MSCs) and secretome on cerebral ischemic injury. MSCs reduce oxidative stress through suppressing reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation and transferring healthy mitochondria to damaged cells. Meanwhile, MSCs exert anti-inflammation properties by the production of cytokines and extracellular vesicles, inhibiting proinflammatory cytokines and inflammatory cells activation, suppressing pyroptosis, and alleviating blood–brain barrier leakage. Additionally, MSCs regulation of autophagy imbalances gives rise to neuroprotection against cerebral ischemic injury. Altogether, MSCs have been a promising candidate for the treatment of ischemic stroke due to their pleiotropic effect.

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<p>Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis</p>

Cited by 34 publications

References 45 publications

The Unique Immunomodulatory Properties of MSC-Derived Exosomes in Organ Transplantation

The Unique Immunomodulatory Properties of MSC-Derived Exosomes in Organ Transplantation

Colchicine-Containing Nanoparticles Attenuates Acute Myocardial Infarction Injury by Inhibiting Inflammation

Oxidative Stress, Inflammation, and Autophagy: Potential Targets of Mesenchymal Stem Cells-Based Therapies in Ischemic Stroke

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