&lt;p&gt;Exosome Derived from Coronary Serum of Patients with Myocardial Infarction Promotes Angiogenesis Through the miRNA-143/IGF-IR Pathway&lt;/p&gt;

Geng, Tao; Zhang, Song; Xing, Jingxian; Wang, Bingxun; Dai, Shipeng; Xu, Zesheng

doi:10.2147/ijn.s242908

Cited by 69 publications

(52 citation statements)

References 52 publications

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“…Further, Peng et al (2020) showed that miR-25-3p secreted by MSCs reduces myocardial infarction area by targeting EZH2; Wen et al (2020) showed that exosomal miR-144 derived from MSCs targets the regulation of the PTEN/AKT pathway, thus improving the apoptosis of cardiomyocytes under hypoxia. Geng et al (2020) showed that miR-143, which is derived from serum exosomes, promotes myocardial angiogenesis through the IGF-IR/NO pathway. Collectively, based on the above, exosomal miRNA is expected to become a new method for the diagnosis and treatment of ACS.…”

Section: Cardiovascular Diseases and Exosomal Mirnasmentioning

confidence: 99%

The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease

Zheng

Huo

et al. 2021

Front. Cell Dev. Biol.

136

106

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Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane bilayer, secreted by most cells in the body. They carry various molecules, including proteins, lipids, mRNA, and other RNA species, such as long non-coding RNA, circular RNA, and microRNA (miRNA). miRNAs are the most numerous cargo molecules in the exosome. They are endogenous non-coding RNA molecules, approximately 19–22-nt-long, and important regulators of protein biosynthesis. Exosomes can be taken up by neighboring or distant cells, where they play a role in post-transcriptional regulation of gene expression by targeting mRNA. Exosomal miRNAs have diverse functions, such as participation in inflammatory reactions, cell migration, proliferation, apoptosis, autophagy, and epithelial–mesenchymal transition. There is increasing evidence that exosomal miRNAs play an important role in cardiovascular health. Exosomal miRNAs are widely involved in the occurrence and development of cardiovascular diseases, such as atherosclerosis, acute coronary syndrome, heart failure (HF), myocardial ischemia reperfusion injury, and pulmonary hypertension. In this review, we present a systematic overview of the research progress into the role of exosomal miRNAs in cardiovascular diseases, and present new ideas for the diagnosis and treatment of cardiovascular diseases.

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Section: Cardiovascular Diseases and Exosomal Mirnasmentioning

confidence: 99%

The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease

Zheng

Huo

et al. 2021

Front. Cell Dev. Biol.

136

106

View full text Add to dashboard Cite

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“…18 Plasma-derived exosomes are released by a wide range of different cells and that can be internalized by nearby or distant cells, thereby altering their functionality, 19 delivering contents such as cholesterol, proteins, and nucleic acids. 20 As they can protect the encapsulated molecules from external factors, Exos are ideal nanovesicles for use when delivering miRNAs and other bioactive materials to target cells in an effort to modulate gene expression. 21 Fibroblasts are able to readily internalize serum-derived Exos 22 and are essential mediators of wound healing owing to their ability to promote collagen synthesis and localized remodeling of diverse tissue types.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Circulating Exosomal miRNA-20b-5p Accelerates Diabetic Wound Repair

Chen

Wang

2021

IJN

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Purpose: Efficient approaches to reliably improving wound healing in diabetic patients remain to be developed. Exosomes are nanomaterials from which therapeutically active microRNAs (miRNAs) can be isolated. In the present report, we therefore isolated circulating exosome-derived miRNAs from patients with diabetes and assessed the impact of these molecules on wound healing. Patients and Methods: Exosomes were isolated from the serum of control or diabetic patients (Con-Exos and Dia-Exos, respectively), after which the effects of these exosomes on cellular activity and wound healing were assessed. Results: We determined that miR-20b-5p was overexpressed in Dia-Exos and that it functioned by impairing wound repair by suppressing vascular endothelial growth factor A (VEGFA) expression. Consistent with such a model, the administration of Dia-Exos or this miRNA both in vivo and in vitro was sufficient to slow wound repair. Conclusion: Dia-Exos exhibit significant increases in miR-20b-5p relative to Con-Exos, and this miRNA can be transferred into HSFs wherein it can suppress VEGFA expression and thereby slow the process of wound healing.

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“…In recent years, it has been found that exosomes were widely participating in the physiological and pathological processes of the cardiovascular system, and play an important role in the evolution of heart diseases (21). Furthermore, it was found that exosomes Serum exosome miR-143 was under-expressed in patients with myocardial ischemia-reperfusion injury, and the overexpression of miR-143 inhibited angiogenesis (26).…”

Section: Discussionmentioning

confidence: 99%

Serum exosomal microRNA-146a as a novel diagnostic biomarker for acute coronary syndrome

Li¹,

Gu²,

Wang³

et al. 2021

J Thorac Dis

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Background: Circulating microRNAs (miRNAs) have emerged as potential biomarkers for cardiovascular diseases. However, few studies have focused on the role of exosomal miRNAs in acute coronary syndrome (ACS). The purpose of this study was to explore weather serum exosomal microRNA-146a (exo-miR-146a) could be used as a novel diagnostic biomarker for ACS and to investigate its relationship with inflammatory response. Methods: A total of 63 ACS patients and 25 patients with normal coronary arteries (Control) were enrolled respectively. The serum exosomes were isolated and then identified by transmission electron microscopy (TEM), western blot, and nanoparticle tracking analysis (NTA). The expression levels of exo-miR-146a in serum were detected by real-time quantitative polymerase chain reaction (RT-qPCR) and the expression levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in serum were assessed by enzyme-linked immunosorbent assay (ELISA). Spearman's correlation analysis was used to appraise the potential factors related to serum exo-miR-146a and receiver operating characteristic (ROC) curve analysis was applied for predicting the accuracy of ACS via the area under curve (AUC). Results: Exosomes isolated from serum were of typical cup-like shape, with 50-150 nm diameter, and expressed CD9, CD63, CD81, and HSP70. The expression levels of serum exo-miR-146a, IL-1β, IL-6, and TNF-α were significantly increased in ACS patients compared with the control group, Spearman′s correlation analysis indicated that exo-miR-146a expression was markedly positively correlated with IL-1β, IL-6, and TNF-α. The ROC curve analyses revealed that exo-miR-146a could distinguish ACS patients from their normal controls. Conclusions: The serum exo-miR-146a may be used as a novel diagnostic biomarker for ACS patients, and it is also associated with inflammatory response.

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<p>Exosome Derived from Coronary Serum of Patients with Myocardial Infarction Promotes Angiogenesis Through the miRNA-143/IGF-IR Pathway</p>

Cited by 69 publications

References 52 publications

The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease

The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease

Inhibition of Circulating Exosomal miRNA-20b-5p Accelerates Diabetic Wound Repair

Serum exosomal microRNA-146a as a novel diagnostic biomarker for acute coronary syndrome

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