<p>Evaluation of anticoagulant activity of aqueous extract of<em> Cestrum nocturnum</em></p>

Abstract

&lt;p&gt;The study evaluated anticoagulant properties of the aqueous extract of &lt;em&gt;Cestrum nocturnum&lt;/em&gt; using aPTT-Activated Partial Thromboplastin Time, PT- Prothrombin Time &amp;amp; TT-Thrombin Time as standard procedures.&lt;/p&gt;&lt;p&gt;For &lt;em&gt;in vitro&lt;/em&gt; coagulation assays, aqueous extract of plant prolonged APTT, TT, and PT clotting times in a dose-dependent manner (Table 7). It prolonged APTT clotting time from 45 ± 2 (2mg/mL) to 82.2 ± 2.63s (10mg/mL), PT clotting time from 20.4 ± 1.49 (2mg/mL) to 31.4 ± 2.15s (10mg/mL), and TT clotting time from 9.2 ± 1.16 (2mg/mL) to 17.4 ± 1.01s (10mg/mL) at the concentration of 2 to 10mg/mL. Heparin prolonged APTT and PT clotting times more than 111.8s and 40.8s, respectively, at a concentration of 1 IU/mL. Heparin prolonged TT clotting times more than 20.6s at a concentration of 1 IU/mL.&lt;/p&gt;&lt;p&gt;The phytochemical screening of the plant confirm the presence of saponin in the water and ethanolic extract, Alkaloid in all the extract except hexane extract, tannin in water, ethanol and methanol extract, amino acid in water and ethanolic extract, carbohydrate in water and methanolic extract and triterpenoids and glycoside were absent in all the extracts. The results demonstrated that the aqueous extract of &lt;em&gt;Cestrum nocturnum&lt;/em&gt; possesses pharmacologically active anticoagulant principles that could be isolated and evaluated for clinical or physiological purposes.&lt;/p&gt;

Systemic Review on Jasminum Polyanthum

“…These components form class of phytochemicals like alkaloids, steroids, saponin, flavonoids etc [2]. If higher level of any bioactive property was found, then it can be used for applications to treat against human physiological diseases provided it does not cause any side effects [3,4].…”

Evaluation of bioactive compounds from Jasminum polyanthum and its medicinal properties

“…So there is a need to explore bioactive compounds in plants as they contribute to medicinal properties and find usage in treating human diseases. These components form class of phytochemicals like alkaloids, steroids, saponin, flavonoids etc 2 . If higher level of any bioactive property was found, then it can be used for applications to treat against human physiological diseases provided it does not cause any side effects.…”