<p>Eosinophilic esophagitis: early diagnosis is the key</p>

Abstract

Eosinophilic esophagitis (EoE) is a disorder which affects all ages, from infancy through adulthood. It typically affects atopic individuals (Table 1) and is a chronic allergic disorder, with foods ubiquitous in the diet being the most described trigger of this isolated eosinophilic inflammation of the esophagus in both adults and children. This inflammatory process leads to esophageal symptoms such as dysphagia and feeding intolerance. In this review, we provide a brief overview of the current state of EoE therapy and symptomatology and then try to make the case for early diagnosis and treatment to prevent some of the long-term consequences of esophageal inflammation.

Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

“…The most common symptoms of EoE, such as dysphagia and food impaction, increase with age and are more common during adolescence. Concomitant atopic conditions should increase the suspicion of EoE [ 33 ]. It is diagnosed on the basis of symptoms of esophageal disfunction and >15 eosinophils per high power field (eos/hpf) on esophageal biopsy [ 34 , 35 ].…”

Examining Unmet Needs in the Management of Eosinophilic Esophagitis

“…The impact of EoE on healthrelated QOL has been shown to increase with disease severity. 2 For example, in a study conducted between March 2013 and May 2014, patients with EoE for at least 17 years who needed an endoscopy for diagnosis, further confirmation of a suspected diagnosis, or monitoring of previously diag nosed EoE were invited to recall their QOL and symptom severity over the last 7 days using validated instruments. 43 Results indicated that the presence of dysphagia was correlated with decreased QOL and increased disability.…”

“…Eosinophilic esophagitis (EoE) is a progressive, chronic inflam matory disease that is associated with a substantial disease burden and longterm complications. 1,2 Early and accurate diagnosis of EoE is critical for preventing worsening, potentially irreversible damage to the esophagus. 2 Esophageal remodeling, narrowing, and fibrosis can occur when EoE is inadequately controlled; the dura tion of untreated disease is the strongest predictor of eso phageal stricture.…”

“…1,2 Early and accurate diagnosis of EoE is critical for preventing worsening, potentially irreversible damage to the esophagus. 2 Esophageal remodeling, narrowing, and fibrosis can occur when EoE is inadequately controlled; the dura tion of untreated disease is the strongest predictor of eso phageal stricture. 3,4 Despite the availability of treatment options, the clinical needs of patients with EoE remain largely unmet.…”

Malnutrition in Eosinophilic Gastrointestinal Disorders

“…As reported in this review, most patients were normal weight or even obese. A meticulous evaluation of the patient’s symptoms should be recommended, and the clinician should ask the right questions to detect suspicious eating habits ( Table 6 ) [ 59 ].…”