<p>Effects of prenatal exposure to temephos on behavior and social interaction</p>

Abstract

The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against Aedes aegypti in Brazil’s public health programs.PurposeTo evaluate behavioral effects of prenatal exposition to temephos in Wistar rats.MethodsFirst, we divided pregnant females into groups: those who received temephos diluted in distilled water by gavage between gestational days 6–13 and those who received only distilled water in the same period and volume. Then, we divided pups according to sex and exposure, and we made the behavioral tests on postnatal day 30.ResultsPrenatal exposure to temephos caused hyperactivity, stereotyped behavior, and social impairment in animals.ConclusionThese results are similar to the altered behavior presented in some neurobiological diseases models, like Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders, and this study may bring a red alert to the large use of temephos in Brazil, due to the damage caused by its exposure.

Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators

“…On the other hand, temephos is toxic to the nervous systems of humans. It can cause Alzheimer’s disease as reported by Martins Laurentino et al 52 . Because of its efficacy and safety, the combined formulation of C .…”

Combinations of plant essential oils and their major compositions inducing mortality and morphological abnormality of Aedes aegypti and Aedes albopictus

“…The secondary reason was its dangerous neurotoxic side effects on humans. It caused the following human diseases: attention deficit hyperactivity disorder, Alzheimer's disease, and schizophrenia ( Martins Laurentino et al., 2019 ). Its strong neurotoxicity for both insects and mammals was exerted through a common cholinergic pathway ( Satriawan et al., 2019 ; Naqqash et al., 2016 ), a vital excitatory neurotransmission system in insects and mammals ( Thany et al., 2010 ; Satriawan et al., 2019 ).…”

Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators

“…On the other hand, temephos is toxic to the nervous systems of humans. It can cause Alzheimer's disease as reported by Martins Laurentino et al 50 . Because of its e cacy and safety, the combined formulation of C. verum EO + geranial should be developed as a natural insecticide for controlling the eggs of Ae.…”