&lt;p&gt;Effects of Lithium Combined with Second-Generation Antipsychotics for the Treatment of Manic Episodes in Patients with Bipolar Disorder: A Naturalistic Study in China&lt;/p&gt;

Yang, Liu; Liang, Jun; Xia, Qingrong; Zhou, Xin; Xie, Xuefeng

doi:10.2147/ndt.s270596

Cited by 3 publications

(2 citation statements)

References 45 publications

(30 reference statements)

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“…The combination of lithium and atypical antipsychotics (AAPs) has been the main common choice for the treatment of bipolar disorder [ 21 ]. Due to the possible side effects of the first-generation antipsychotics, the second-generation antipsychotics (also called AAPs) were gradually introduced in therapy [ 22 ]. Currently, no studies have focused on the possible actions of AAPs in glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Lithium and Atypical Antipsychotics: The Possible WNT/β Pathway Target in Glaucoma

Vallée

Lecarpentier³

2021

Biomedicines

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Glaucoma is a progressive neurodegenerative disease that represents the major cause of irreversible blindness. Recent findings have shown which oxidative stress, inflammation, and glutamatergic pathway have main roles in the causes of glaucoma. Lithium is the major commonly used drug for the therapy of chronic mental illness. Lithium therapeutic mechanisms remain complex, including several pathways and gene expression, such as neurotransmitter and receptors, circadian modulation, ion transport, and signal transduction processes. Recent studies have shown that the benefits of lithium extend beyond just the therapy of mood. Neuroprotection against excitotoxicity or brain damages are other actions of lithium. Moreover, recent findings have investigated the role of lithium in glaucoma. The combination of lithium and atypical antipsychotics (AAPs) has been the main common choice for the treatment of bipolar disorder. Due to the possible side effects gradually introduced in therapy. Currently, no studies have focused on the possible actions of AAPs in glaucoma. Recent studies have shown a down regulation of the WNT/β-catenin pathway in glaucoma, associated with the overactivation of the GSK-3β signaling. The WNT/β-catenin pathway is mainly associated with oxidative stress, inflammation and glutamatergic pathway. Lithium is correlated with upregulation the WNT/β-catenin pathway and downregulation of the GSK-3β activity. Thus, this review focuses on the possible actions of lithium and AAPs, as possible therapeutic strategies, on glaucoma and some of the presumed mechanisms by which these drugs provide their possible benefit properties through the WNT/β-catenin pathway.

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Section: Introductionmentioning

confidence: 99%

Lithium and Atypical Antipsychotics: The Possible WNT/β Pathway Target in Glaucoma

Vallée

Lecarpentier³

2021

Biomedicines

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“…(2020) 24 investigated the therapeutic efficacy of lithium combined with second-generation antipsychotics, specifically quetiapine, clozapine, olanzapine, and risperidone, for the treatment of manic episodes in bipolar disorder patients (BD). They looked at data from individuals with bipolar disorder who had manic episodes and were admitted to a Class 3A Psychiatric Hospital in Anhui Province between January 2015 and October 2019.…”

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confidence: 99%

A Review of Repercussions of Lithium Amalgamated with Antipsychotics for the Remedy of Bipolar Disorder

R.¹,

Venkateswaramurthy²

2023

J. Drug Delivery Ther.

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Bipolar disorder is a brain illness that causes mood, energy, and ability to function variations. Bipolar illness patients have extreme emotional states that often occur over a period of days to weeks, referred to as mood episodes. Manic/hypomanic (abnormally cheerful or angry mood) or depressed (sad mood) mood episodes are classified. People with bipolar disorder frequently have periods of neutral mood. People with bipolar disorder can live long and productive lives if they are treated. The management of BD may be summarized into 2 phases, acute treatment and long-term prevention. Lithium was observed to have a unique therapeutic profile, including mood-stabilizing effects, as well as anti-suicidal and neuroprotective properties.13 It is available in many different salt forms, namely lithium carbonate, lithium citrate, lithium chloride, and lithium sulfate. A meta-analysis discovered that a combination regimen of haloperidol, olanzapine, risperidone, and quetiapine was substantially more effective in treating BD manic episodes than monotherapy with a mood stabiliser, but the combination regimen was less well tolerated than monotherapy. Keywords: Bipolar Disorder, Lithium, Monotherapy, Combination therapy, Adverse effects.

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Risks and benefits of clozapine and lithium co-prescribing: A systematic review and expert recommendations

Verdoux

Quilès

León

2024

Schizophrenia Research

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<p>Effects of Lithium Combined with Second-Generation Antipsychotics for the Treatment of Manic Episodes in Patients with Bipolar Disorder: A Naturalistic Study in China</p>

Cited by 3 publications

References 45 publications

Lithium and Atypical Antipsychotics: The Possible WNT/β Pathway Target in Glaucoma

Lithium and Atypical Antipsychotics: The Possible WNT/β Pathway Target in Glaucoma

A Review of Repercussions of Lithium Amalgamated with Antipsychotics for the Remedy of Bipolar Disorder

Risks and benefits of clozapine and lithium co-prescribing: A systematic review and expert recommendations

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