&lt;p&gt;Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells&lt;/p&gt;

Chen, Fang; Wang, Xiaohui; Fu, Shuang; Wang, Shaokun; Fu, Yu; Liu, Zhuogang; Zhang, Jihong

doi:10.2147/cmar.s259393

Cited by 15 publications

(10 citation statements)

References 29 publications

(28 reference statements)

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“…Therefore, it is crucial to investigate the potential pathogenic mechanisms of the occurrence and development of MM, especially in terms of proliferation and apoptosis in order to develop new treatment strategies ( 1 ). In recent years, the use of non-coding RNAs (including miRNAs, long non-coding RNAs, circular RNAs, and siRNA) has become increasingly popular for studying the mechanisms and treatments of MM ( 23 , 24 ). This present study demonstrated that miR-19a-3p was significantly down-regulated in MM patients and cell lines.…”

Section: Discussionmentioning

confidence: 99%

The microRNA miR-19a-3p suppresses cell growth, migration, and invasion in multiple myeloma via the Wnt/β-catenin pathway

Wei¹,

Wang²,

Li³

et al. 2021

Transl Cancer Res TCR

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Background MicroRNAs have been suggested as potential regulators in the development of multiple myeloma (MM) through affecting the expression of their target genes. This study aimed to investigate the effects of miR-19a-3p in MM, and its underlying mechanisms in regulating cell proliferation and invasion. Methods Bone marrow samples from 25 MM patients and 12 healthy donors were collected and miR-19a-3p and Wnt1 mRNA expression was assessed. The effects of miR-19a-3p on cell proliferation, migration, and invasion in U226 and RPMI-8226 MM cells were evaluated by miR-19a-3p overexpression. Luciferase assays were performed to explore the potential target genes. Knock down or overexpression of Wnt1 was used to explore the effects of miR-19a-3p on cell growth, migration, and invasion. Results The expression of miR-19a-3p was downregulated in MM and cell lines, while Wnt1 mRNA levels were increased. Overexpression of miR-19a-3p inhibited cell proliferation, migration, and invasion in U226 and RPMI-8226 cells. Additionally, western blot assays revealed that miR-19a-3p could suppress Wnt1, β-catenin, cyclin D1, and c-Myc expression. Knockdown of Wnt1 also inhibited cell growth, migration, and invasion. Moreover, luciferase reporter assay revealed direct binding between Wnt1 and miR-19a-3p. Wnt1 overexpression partially reversed the suppressive effects of miR-19a-3p on cell proliferation, migration, and invasion in U266 cells. Conclusions The expression of miR-19a-3p was downregulated in MM patients and MM cell lines. Overexpression of miR-19a-3p inhibited proliferation, migration, and invasion by targeting Wnt1 via the Wnt/β-catenin signaling pathway.

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Section: Discussionmentioning

confidence: 99%

The microRNA miR-19a-3p suppresses cell growth, migration, and invasion in multiple myeloma via the Wnt/β-catenin pathway

Wei¹,

Wang²,

Li³

et al. 2021

Transl Cancer Res TCR

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“…The expression of circ_0069767 was remarkably higher in MM patients than in healthy subjects, but MM subjects with higher expression of circ_0069767 had longer PFS and OS, as if the increased presence of the circRNA caused a reduction of growth and diffusion and increased programmed cell death; moreover, knockdown of circ_0069767 provoked the opposite biological effects. As far as the mechanisms via circ_0069767 exert their actions, it was demonstrated that this circRNA, by sponging miRNA-636 in MM cells, controls cell generation [ 71 ].…”

Section: Circrnas and Multiple Myelomamentioning

confidence: 99%

Circular RNA as a Novel Biomarker for Diagnosis and Prognosis and Potential Therapeutic Targets in Multiple Myeloma

Allegra

Cicero

Tonacci

et al. 2022

Cancers

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Circular RNAs (circRNAs) are a novel type of covalently closed RNAs involved in several physiological and pathological processes. They display tissue-specific expression and are constant, abundant, and highly conserved, making them perfect markers for diagnosis and prognosis. Several studies have proposed that circRNAs are also differentially produced in malignancies where they have oncogenic effects. Furthermore, circRNAs affecting microRNAs modify the expression profile of several transcription factors which play essential roles in tumors. CircRNAs within the hematopoietic compartment were identified as modulators of mechanisms able to enhance or suppress tumor progression in blood malignancies. Moreover, several circRNAs were suggested to confer resistance to the conventional drugs employed in hematopoietic cancers. In this review, we highlight the growing role and the controlling mechanisms by which circRNAs modify multiple myeloma genesis. We propose that circRNAs can be considered as potential diagnostic and prognostic markers, can induce chemoresistance, and might represent novel therapeutic targets for multiple myeloma.

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“…Meanwhile, circRNAs have been shown to regulate the invasion and migration of cells and further promote the progression of hematological malignancies, such as overexpressing circ-0069767 decreases the invasion and migration capacities of MM cells by sponging miR-636 to regulate the expression of K-RAS [72], whereas circ-0000142 enhances the invasion of MM cells via the circ-0000142/miR-610/AKT3 axis [73], etc.…”

Section: Circrnas Regulate the Proliferation Apoptosis Cell Cycle Inv...mentioning

confidence: 99%

Roles of circRNAs in hematological malignancies

Deng

Zhang

et al. 2022

Biomark Res

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As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of patients after treatment represent clinical challenges. Therefore, there are pressing demands to uncover biomarkers to indicate the development, progression, and therapeutic targets for hematologic malignancies. Circular RNAs (circRNAs) are covalently closed circular-single-stranded RNAs whose biosynthesis is regulated by various factors and is widely-expressed and evolutionarily conserved in many organisms and expressed in a tissue−/cell-specific manner. Recent reports have indicated that circRNAs plays an essential role in the progression of hematological malignancies. However, circRNAs are difficult to detect with low abundance using conventional techniques. We need to learn more information about their features to develop new detection methods. Herein, we sought to retrospect the current knowledge about the characteristics of circRNAs and summarized research on circRNAs in hematological malignancies to explore a potential direction.

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<p>Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells</p>

Cited by 15 publications

References 29 publications

The microRNA miR-19a-3p suppresses cell growth, migration, and invasion in multiple myeloma via the Wnt/β-catenin pathway

The microRNA miR-19a-3p suppresses cell growth, migration, and invasion in multiple myeloma via the Wnt/β-catenin pathway

Circular RNA as a Novel Biomarker for Diagnosis and Prognosis and Potential Therapeutic Targets in Multiple Myeloma

Roles of circRNAs in hematological malignancies

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