<p>EDTA-modified mesoporous silica as supra adsorbent of copper ions with novel approach as an antidote agent in copper toxicity</p>

Abstract

PurposeMesoporous silica (MS) have been considered as a biocompatible compound and found to have various pharmaceutical applications. Recently, novel approaches in applications of MS as antidote agents were introduced. In this study, the capacity of ethylenediaminetetraacetic acid modified mesoporous silica (MS-EDTA) was evaluated in in vitro and in vivo adsorption of copper (Cu).MethodsThe MS-EDTA was characterized by fourier transform infrared (FT-IR) and X-ray diffraction, while surface area was determined by N2 adsorption–desorption technique. Morphological studies were observed by high resolution-transmission electron microscopy and field emission-scanning electron microscopy and the sizes were determined by dynamic light scattering. The capacity of these particles for copper adsorption was investigated in vitro in both 1.2 and 7.2 pH. In in vivo animal study, the Cu adsorption efficiency of MS-EDTA in Cu-overdosed mice was evaluated. In this case, an animal model of acute copper poisoning was prepared.ResultsThe MS-EDTA with surface area of 352.35 was synthesized. Scanning electron microscope showed spherical particle formation with less than 500 nm in size. Transmission electron microscope images showed porous and honeycomb structure. FT-IR spectroscopy showed an appropriate formation of functional groups. Particle efficiency was investigated for Cu adsorption. MS-EDTA in both media showed a high adsorption capability for Cu (II) adsorption in pH=1.2 and pH=7.2. In addition, the study of Langmuir, Freundlich, and Redlich–Peterson adsorption models showed that copper adsorption by MS-EDTA followed the Freundlich model with multi-layer adsorption. In vivo evaluation showed that MS-EDTA could alleviate the symptoms of acute copper poisoning by lowering Cu plasma levels.ConclusionStructural evaluation showed successful formation of MS-EDTA. In vitro analysis demonstrated that supreme Cu adsorption occurs in both pH conditions (7.2 and 1.2), and was especially more favorable in simulated intestinal pH (7.2). The in vivo studies in animal models with acute Cu poisoning showed that MS-EDTA could be a potent antidote agent.

<p>In vitro and in vivo Evaluation of Succinic Acid-Substituted Mesoporous Silica for Ammonia Adsorption: Potential Application in the Management of Hepatic Encephalopathy</p>

“…The MS-NH 2 preparation method is summarized here. 19 Firstly, 4.8 g of CTAB (13.2 mmol) as a surfactant template was dissolved in 100 mL of deionized water. In the next step, 26 mL of ammonia was added to the above solution.…”

“… 13 In this regard, Farjadian et al reported that EDTA modified MS could be potent antidote agents while assessed in vitro and in vivo in adsorption of iron 18 and copper. 19 …”

Repurposing of sevelamer as a novel antidote against aluminum phosphide poisoning: An in vivo evaluation

“…In continuous of our previous studies in the field of toxicology by introducing novel antidote agents made of mesoporous silica with high capacity in adsorption of paracetamol and phenobarbital [ 18 ], iron [ 19 ], and copper [ 20 ], and management of hepatic encephalopathy [ 17 ], herein, SVLM is repurposed as a distinguishing antidote of AlP.…”

Short-Term Oral Administration of Mesoporous Silica Nanoparticles Potentially Induced Colon Inflammation in Rats Through Alteration of Gut Microbiota

“…Also, it would be easy for the modification of the functional group on MSNs’ surface to achieve the long period release of therapeutic agents. 2 , 3 For example, Shah’s group 4 fabricated a Velpatasvir (VLP) loaded MSNs with good biocompatibility, and this MSNs based drug delivery system showed prolonged VLP release both in vitro and in vivo. Meantime, a study by Yang et al 5 revealed a preparation of Breviscapine (BRE) loaded MSNs, which showed higher dissolution rate and higher oral absorption than BRE powder.…”