<p>Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report</p>

Abstract

We have comprehensively documented a case of semantic variant of primary progressive aphasia (sv-PPA) presenting with early-onset pathological gambling (PG). While a growing number of studies have shown the presence of behavioral alterations in patients with sv-PPA, PG has been observed only in the behavioral variant of frontotemporal dementia (bv-FTD). To date, no case of PG with the co-occurrence of prominent semantic deficits at the onset of the disease has been reported in the literature. Impulse disorders at onset may wrongly lead to a misdiagnosis (ie, psychiatric disorders). Therefore, a wider characterization of cognitive/aphasia symptoms in patients presenting impulse disorders and predominant language dysfunctions is recommended.

Primary Progressive Aphasia Presenting With Neuropsychiatric Symptoms

“…27 Battista et al reported a case of semantic PPA presenting with an impulse disorder reflected in the early-onset pathological gambling. 28 Fatemi et al conducted a case-control study using the Neuropsychiatric Inventory (NPI) to compare neuropsychiatric symptoms in PPA to individually matched controls. Associated with PPA were apathy, agitation, anxiety, depression, appetite change and irritability.…”

“…27 Battista et al reported a case of semantic PPA presenting with an impulse disorder reflected in the early-onset pathological gambling. 28…”