&lt;p&gt;Dysregulation of MiR-30a-3p/Gastrin Enhances Tumor Growth and Invasion throughSTAT3/MMP11 Pathway in Gastric Cancer&lt;/p&gt;

Liu, Yan; Gao, Meng; An, Juan; Wang, Xin; Jia, Yan; Xu, Junfeng; Zhu, Jihai; Cui, Jiantao; Li, Wenmei; Xing, Rui; Li, Song; Liu, Kejia; He, Yuqi; Sheng, Jian-qiu; Qi, Shengmei; Pan, Yuanming; Lü, Youyong

doi:10.2147/ott.s235022

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Increased gastrin levels were correlated with elevated STAT3 activation with subsequent MMP11 expression. This study demonstrated that miR‐30a‐3p negatively modulates gastrin and represses the STAT3 pathway to impair GC cell invasion 174 …”

Section: Ncrnas and Stat3 Regulation In Gastrointestinal Cancersmentioning

confidence: 69%

“…This study demonstrated that miR-30a-3p negatively modulates gastrin and represses the STAT3 pathway to impair GC cell invasion. 174 Some bacterial and viral infections are responsible for the development of various malignancies including GC and liver cancer. H. pylori and Epstein-Barr virus are well-studied in relevance to the development of GC.…”

Section: Gastric Cancermentioning

confidence: 99%

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Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

Ashrafizadeh

Mohan

Rangappa

et al. 2023

Medicinal Research Reviews

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Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic transcription factor that promotes the transcription of genes associated with proliferation, antiapoptosis, survival, and metastasis. STAT3 is overactivated in many human malignancies including GI tumors which accelerates tumor progression, metastasis, and drug resistance. Research in recent years demonstrated that noncoding RNAs (ncRNAs) play a major role in the regulation of many signaling pathways including the STAT3 pathway. The major types of endogenous ncRNAs that are being extensively studied in oncology are microRNAs, long noncoding RNAs, and circular RNAs. These ncRNAs can either be tumor‐promoters or tumor‐suppressors and each one of them imparts their activity via different mechanisms. The STAT3 pathway is also tightly modulated by ncRNAs. In this article, we have elaborated on the tumor‐promoting role of STAT3 signaling in GI tumors. Subsequently, we have comprehensively discussed the oncogenic as well as tumor suppressor functions and mechanism of action of ncRNAs that are known to modulate STAT3 signaling in GI cancers.

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Section: Ncrnas and Stat3 Regulation In Gastrointestinal Cancersmentioning

confidence: 69%

Section: Gastric Cancermentioning

confidence: 99%

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

Ashrafizadeh

Mohan

Rangappa

et al. 2023

Medicinal Research Reviews

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“…Yan Liu et al. found that GAST can regulate cell proliferation and metastasis related to gastric cancer prognosis through STAT3/MMP11 pathway ( 53 ). Bing Tan et al.…”

Section: Discussionmentioning

confidence: 99%

MMP11 is associated with the immune response and immune microenvironment in EGFR-mutant lung adenocarcinoma

et al. 2023

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BackgroundHigh expression of matrix metalloproteinase-11 (MMP11) is associated with various tumors and immune microenvironments. Conversely, poor response to immunotherapy in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) patients is closely related to the characteristics of immune microenvironment.MethodsThe Cancer Genome Atlas (TCGA)-LUAD database and our gathered clinical LUAD samples were used to examine the relationship between MMP11 expression and EGFR mutation. Then the correlation between MMP11 and immune response and the difference of immune cell infiltration in different groups were analyzed. Compared the differences in the immune microenvironment between the MMP11-positive and MMP11-negative expression groups using immunohistochemistry (IHC) and multiplex immunohistochemistry.ResultsThe expression of MMP11 in samples with exon 19 deletions, exon 21 L858R or de novo exon 20 T790M mutations was higher than wild type, but there was no difference between the samples with uncommon mutation and the wild-type. The high MMP11 expression group had a higher Tumor Immune Dysfunction and Exclusion (TIDE) score. Pathways associated with enrichment in the extracellular matrix (ECM) were the main biological functions of differential genes between the high and low MMP11 groups. The IHC score of MMP11 in the EGFR-mutant group was higher than in the EGFR-wild group. In TCGA-LUAD, the high MMP11 group had a lower proportion of T cell CD8+ and NK cells activated. In the clinical samples, the infiltration levels of T cell CD8+ and NK cells in the tumor parenchyma of EGFR-mutant LUAD was lower in the MMP11-positive than in the MMP11-negative group. The expression levels of tumor cell PD-L1 were higher in the MMP11-positive expression group than in the MMP11-negative expression group, and the proportion of PD1+CD8+ T cells infiltrated was reduced in the MMP11-positive group compared to the MMP11-negative group.ConclusionsHigh expression of MMP11 was associated with EGFR mutations. Patients with EGFR-mutant LUAD with high expression of MMP11 responded poorly to immunotherapy, and the percentage of T cell CD8+ and NK cells in immune cell infiltration was lower in MMP11. Consequently, MMP11 is related to the immunological microenvironment of EGFR-mutant lung adenocarcinoma, which may be a predictor of possible immunotherapeutic response.

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“…In addition, miR-30a-3p has been reported to play a key role in several types of cancer [14][15][16]. In gastric cancer, miR-30a-3p mediates cancer cell invasion via STAT3/MMP11 signaling [17]. In liver cancer cells, miR-30a-3p attenuates proliferation via targeting DNMT3a [18].…”

Section: Agingmentioning

confidence: 99%

Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2

Zhou

Wang

et al. 2021

Aging

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Background: There is a well-established relationship between cell cycle progression and the development of stomach adenocarcinoma. This study aimed to elucidate the molecular mechanism and biological function of APBB2 in gastric cancer. Methods: Gastric adenocarcinoma (GA) data were downloaded from the TCGA-GA and GEO databases and analyzed to explore differentially expressed miRNAs and mRNAs. Moreover, potential target mRNAs were also predicted. The relative level of gene and protein expression in GA cell lines and gastric mucosa cells was detected by q-PCR and Western blot, respectively. Moreover, the influence of APBB2 on proliferation, metastasis, and cell cycle changes in SGC-7901 and BGC-823 cells was evaluated. The binding relationship between the target miRNA and mRNA was confirmed with a dual-luciferase reporter assay. Results: High APBB2 expression was detected in GA patients, indicating that it may be represent a predictive biomarker for poor prognosis. Related experiments confirmed that APBB2 silencing inhibited GA cellular functions, including proliferation, cell cycle progression, migration, and invasion. In addition, to explore the molecular mechanism, our results indicated that the binding sites were located at hsa-mir-30a and the 3′-UTR of APBB2, suggesting that hsa-mir-30a can regulate the expression of APBB2. The biological functions of hsamir-30a were also evaluated. Hsa-mir-30a overexpression attenuated the proliferation and metastasis of cancer cells. In rescue experiments, hsa-mir-30a was confirmed to reverse the cell cycle promoting function associated with APBB2 overexpression. Conclusion: Our findings show that hsa-mir-30a can attenuate the development of GA by down-regulating APBB2 expression.

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<p>Dysregulation of MiR-30a-3p/Gastrin Enhances Tumor Growth and Invasion throughSTAT3/MMP11 Pathway in Gastric Cancer</p>

Cited by 7 publications

References 24 publications

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response

MMP11 is associated with the immune response and immune microenvironment in EGFR-mutant lung adenocarcinoma

Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2

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