<p>Diurnal Stability Of Peripapillary Vessel Density And Nerve Fiber Layer Thickness On Optical Coherence Tomography Angiography In Healthy, Ocular Hypertension And Glaucoma Eyes</p>

Abstract

PurposeBy using optical coherence tomography angiography (OCTA), to evaluate diurnal changes of the following parameters: vessel density in the peripapillary area (PP-VD) and in the optic nerve head (ONH-VD); thickness of retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC).MethodsAll prospectively enrolled participants were imaged on the same day at 8 am and 7 pm by means of the XR Avanti device with AngioVue and AngioAnalytics software (Optovue Inc., Fremont, CA, USA). Only eyes with correct automatic segmentation and good-quality images (scan quality > 7/10) were included.ResultsForty-six eyes from 28 patients with glaucoma, 53 from 31 patients with ocular hypertension, and 62 from 38 controls were assessed. The mean measurements of all parameters investigated were significantly different in the morning and in the evening values in all three groups, with lower values in glaucomatous eyes (p<0.014). In control eyes, as well as in eyes of patients with ocular hypertension and glaucoma the daily changes were minimal and not statistically significant with means of +0.17%, −0.31% and −0.54% for ONH-VD (p=0.83) and means of +0.2%, +0.1% and +0.29% for PP-VD (p=0.83), respectively. Likewise, daily fluctuations in GCC and RNFL thickness were not significant in any of the three groups, with means of +0.16 µm, +0.66 µm and −0.15 µm for GCC (p=0.58) and means of +0.24 µm, +0.58 µm and −0.24 µm for ONH-RNFL (p=0.90), respectively. Systemic hypertension, age, axial length, daily changes in intraocular pressure or scan quality did not correlate with daily fluctuations of any of the parameters investigated (p>0.1).ConclusionVessel density, GCC and RNFL were stable during daytime thus corroborating the clinical relevance of OCTA regardless the time of acquisition.

Densidad vascular macular y peripapilar medida con angiografía por tomografía de coherencia óptica en glaucoma preperimétrico, hipertensos oculares y ojos normales

“…Se registraron también la desviación media y el índice de campo visual visual. Se estimó un tamaño de muestra de 30 ojos en cada grupo 25 .…”

APSified OCT-angiography analysis: Macula vessel density in healthy eyes during office hours

“…Circadian variations have already been described for parameters like axial length (AL), choroidal thickness (CT) or intraocular pressure (IOP) [7][8][9][10][11]. However, very little is known to date about diurnal fluctuations in retinal perfusion visualized by OCT-A, and so far there are only few published data [12][13][14][15][16][17][18].…”

Magnitude of Diurnal Change in Retinal Vessel Density: Comparison Between Exfoliative Glaucoma and Primary Open-Angle Glaucoma

“…Specific optical coherence tomography angiography (OCTA) studies have already shown the extent of the fluctuations occurring in diurnal retinal vessel density (VD) in patients with various types of glaucoma (1)(2)(3)(4)(5)(6)(7)(8)(9). Several studies have indicated a substantial change in retinal VD; some have demonstrated a continuing decline in retinal VD throughout the day (2,4).…”

“…Several studies have indicated a substantial change in retinal VD; some have demonstrated a continuing decline in retinal VD throughout the day (2,4). However, other researchers have observed that retinal VD levels were consistent the entire day (3,5,9). The objective of this research was to use OCTA to investigate the magnitude of diurnal fluctuation in the peripapillary (pp) and parafoveal (pf ) VD in exfoliative glaucoma (XFG) patients and to compare the findings with those of primary open-angle glaucoma (POAG) patients with glaucomatous damage of comparable severity.…”